Mishonga inonzi mirogabalin iri kupa tariro yekusunungurwa kwechiratidzo uye zvishoma nezvimwe zvinokonzera kudarika mishonga ye fibromyalgia (FMS) inopiwa. Yakafambisa zvikuru kuti uzive zvechokwadi, zvakadaro.
Mirogabalin mishonga yekuedza ndiyo iyo yechitatu nhengo ye "mhuri" yemishonga inozivikanwa kumusangano weFMS. Vatungamiri varo ndiNeurontin (gabapentin) uye Lyrica (pregabalin) , iyo yakanzi "mwanakomana weNeurontin."
Neurontin neRyrica zvose zvinopesana nemishonga yakagadziriswa iyo yakawanikwa iine simba kuburikidza nekurwadziwa kwehutachiona hwehutachiona hwehutachiona . Lyrica yaiva iyo FDA-yakagamuchirwa kuti FMS neNeurontin inowanzorongedzerwa kure-label kwairi. Iyo inoshandiswawo kune mamwe marudzi ekurwadziwa, kusanganisira kurwa kweputi -chirwere uye postherpetic neuralgia .
Mirogabalin, zvisinei, yakave yakagadzirwa zvakananga nehutano hweuropathy uye FMS mupfungwa.
Sei Mirogabalin Inoshanda
Maererano nechigadzirwa chemishonga cheJapan Daiichi Sankyo, mirogabalin inosungira kune calcium chiteshi muuropi, saRyrica neNeurontin. Zvisinei, mirogabalin inonzi inosunga zvakasarudzwa kupfuura Lyrica, iyo inogona kuita kuti iite kuti zvive nemigumisiro shoma.
Pari zvino, migumisiro yakaipa inogona kuva dambudziko guru naRyrica, Neurontin, nemamwe madhiragi eFMS. Kutaura zvazviri, vanhu vakawanda vanomira kushandisa mishonga iyi nekuda kwavo. Kana zvakatarisira zvekare zvakatora uye mirogabalin inopa ruzivo rwekurwadziwa nehuwandu husingaiti maitiro, ingadai iri basa guru kune vanhu vane chirwere ichi.
Mirogabalin inofanirwawo kuti yakagara kwenguva refu kupfuura Lyrica, zvinoreva kuti inogona kudiwa kutorwa kashoma. Chidzidzo chaJanuary 2016 chakaratidza kuti chidimbu chemazuva maviri-zuva rose chingave chakanakisisa pakuderedza migumisiro yechirwere.
NeFibromyalgia neNeuropathy
Daiichi Sankyo iye zvino ari kutungamirira chiuru-munhu kudzidza pa mirogabalin yeFMS.
Icho chikuru-kuru (uye saka zvakadhura) chidzidzo chekutanga kwegadziriro, iyo inoratidza kuti kambani inofunga nezvemigumisiro.
Dzidzo dzezvinodhaka dzakawanda dzinowanzofananidza mishonga ye placebo, asi iyi inobata mirogabalin musoro-kw-musoro pamusoro peRyrica.
Chimwe chidzidzo chakabudiswa muna 2014 chakaratidza kuti mirogabalin yakaratidza chivimbiso senzira yekurapa chirwere cheshuga chirwere cheuropathy.
Chimwe chiongorori chekufungidzira chakafungidzira kuti mirogabalin inogona kunge yakawanda kanomwe ka17 yakawanda kupfuura Lyrica; zvisinei, vamwe vatsvakurudzi vakatsoropodza zvidzidzo zvekudzidza.
Dosage
Dhigirii yakakodzera ye miragabalin haisati yasimbiswa. Chidzidzo icho chakawana huwandu hunomwe hutatu hwakataurwa pamusoro apa hunofungidzira kuti muyero uyu ungangodaro uri 17.5 mg kana wakaderera, uchienzanisa 150 mg yemusi weRyrica zuva rimwe nerimwe.
Neuropathy zvidzidzo zviri kushandisa 15 mg, 20 mg, kana 30 mg doses.
Uchapupu hwepakutanga hunoratidza kuti miviri yakadzika inogona kudiwa kune avo vane zvinetso zvakakomba kana zvakakomba zvepvo.
Migumisiro Yechipfuva uye Manyevero
Migumisiro inobvira inogona kuitika nemishonga uye huwandu hwakakwana hwavo kazhinji hahuzivikanwe kusvikira vambove pamusika kwemakore mashomanana.
Kusvika ikozvino, kutsvakurudza kwakaratidza kuti mirogabalin inogona kubatanidzwa kune:
- chizoro
- hope
- kurara kwenguva yakareba kwenguva refu
- headache
Rini Mirogabalin Richawanikwa?
Kutsvakurudza kwezvokurapa inzira inononoka zvikuru. Nekutongwa kukuru kwekutanga kwakatanga muna 2015, uye kusanganisira nhamba huru yevatori vechikamu, hatigoni kutarisira kuona zvingangoita makore mashomanana.
Kana mirogabalin ichiri kuramba ichiratidza chivimbiso uye New Application Drug Inosvika pamberi peDFA, inogona kutora mamwe makore maviri kuitira kuti igamuchirwe kana kurambwa.
Saka kunyange zvazvo zvichikurudzira kuziva kuti kurapwa kunopa kuponeswa nemarwadzo mashoma kunogona kuva mune ramangwana redu, tinoda kuramba tichitsvaga kurapwa ikozvino kunogona kutibatsira kutarisira zviratidzo.
> Sources:
> Boston Clinical Trials. "Chii Chinonyanya Kuvimbisa Pamusoro peMirogabalin? Zvinyorwa zvinotaura nezvekudzidza kwedu kweFibromyalgia itsva." Kodzero dzose dzakachengetedzwa.
> Calandre EP, Rico-Villademoros F, Slim M. Expert review of neurotherapeutics. 2016 Jul 7: 1-15. [Epub mberi kwekudhindwa] Alpha2delta ligands, gabapentin, PGB uye MGB: kuongororwa kwekliniki yavo yekurapa uye yekurapa.
> Daiichi Sankyo Company, Limited. "Daiichi Sankyo Inotanga Varwere Vokutanga MuGuru-zhinji, Multi-National Phase 3 Clinical Programs for MIrogabalin." Kodzero dzose dzakachengetedzwa.
> Hutmacher MM, et al. Zvinyorwa zvemakiriniki ezvemakemikari. 2016 Jan; 56 (1): 67-77. Kunyatsotarisa-kutarisa kuenzanisa kwemazuva ose ekurwadziwa kwemazuva ose, uye chizuru uye somnolence, nokuda kwemirogabalin (DS-5565) kune varwere vane chirwere cheshuga chinokonzera marwadzo europathic.
> Nyaya Drug Dzakabvumirwa. "Mirogabalin." Kodzero dzose dzakachengetedzwa.
> Vinik A, et al. Chirwere cheshuga. 2014 Dec; 37 (12): 3253-61. Kubudirira uye kuchengeteka kwe mirogabalin (DS-5565) yekurapa chirwere cheshuga chinoputika neuropathic marwadzo: randomized, double-blind, placebo- uye yakashanda comprator-controlled, adaptive proof-of-concept phase 2 study.
> Yin OQ, et al. Zvinyorwa zvemakiriniki ezvemakemikari. 2016 Feb; 56 (2): 203-12. Kuenzanisa kwemafaromokinetic ehurumende uye kuenzanisa kwekuongorora kuora kwekuora kwemaitiro pane pharmacokinetics ye mirogabalin.