Vashandi vaviri veNSAID Vanowedzera Dambudziko reMigumisiro Yechipfuva
Zvisiri-steroidal anti-inflammatory drugs (NSAIDs) ndezvokutanga kune vanhu vazhinji vane arthritis. Asi kutora mishonga inopfuura imwechete munharaunda iyi haisi kungopa zvipo zvishomanana asi zvinogona kunge zvisina ngozi. Ndezvipi chaizvo zvinonzi NSAIDs, ndezvipi njodzi, uye ndeipi mishonga inowanikwa mune izvi kuitira kuti iwe uone kuti hauna kujeka kaviri pane imwechete yemishonga?
Ndezvipi Zvisiri-Steroidal Anti-Inflammatory Drugs (NSAIDs)?
Nonsteroidal anti-inflammatory drugs (NSAIDs) ikirasi yemishonga inowanzonyatsorongerwa kurapa arthritis .
Sezvo NSAID dziripo zvose nemirairo uye pamusoro pekambani, vamwe vanhu vanopedza kutora NSAID mbiri dzakasiyana.
Vanhu vanogonawo kusarudza kutora NSAID mbiri nekuda kwekuregererwa kwepfungwa kusina kukwana kana kuti havazivi kuti mishonga yose iri mune imwechete yekurapa mishonga yechirwere. Kushandisa NSAID mbiri dzakasiyana pamwe chete hazvina ngozi uye kwete pfungwa yakanaka, sezvo kuita kudaro kunogona kuwedzera njodzi yezvakaipa zvisina kunaka uye zviitiko zvakakomba zvakaipa.
NSAID dzakakurumbira dzine ngozi
Iwe unogona kufunga nezvemudumbu kunotsamwiswa semugumisiro unowanikwa wekutora mishonga yakadai seAppil, asi kune dzakawanda zvinogona kuitika kusingaiti iwe waunofanira kuziva.
Kubuda kwepamuviri kubuda ropa: Mamiriyoni evanhu anotora NSAIDs zuva rimwe nerimwe nokuda kweArthritis, kukuvadza kwakanyanya, uye kupera kwemwedzi.
Inofungidzirwa kuti vanopfuura 100 000 vekuAmerica vari muchipatara uye pakati pe15 000 ne20,000 vanofa gore roga roga kubva kune zvipembenene uye kubuda kwepamuviri kunokonzerwa nekushandiswa kweNSAID. (Kuti vanzwisise huwandu hweizvi, vakadzi vanenge 40 000 vanorwara nekenza yepamuviri gore negore.) NSAID dzinokwana 60 muzana yemitemo yakawanda-ye-counter yakatengwa, uye yevanhu vanoshandisa NSAID nokuda kwechikonzero chero chipi zvacho, rimwe chete kusvika kune maviri muzana richawana GI kubuda ropa.
Kutaura chete nezveArthritis, varwere vane mamiriyoni 14 vanotora NSAIDs nguva dzose-kusvika makumi matanhatu kubva muzana avo vanozoona maitiro emigumisiro semugumisiro. Dambudziko iri rakanyanya kune avo vakwegura, avo vari kutora aspirin kana kuti vanoonda ropa, vanotora mhando dzakasiyana-siyana uye zviyero zveNSAID, uye kana mishonga inopfuura imwechete munyaya ino inoshandiswa.
Kurwisa kwemwoyo uye ngozi yekurohwa: NSAID kushandiswa kunobatanidza nehuwandu hwekurwadziwa kwepfungwa kana chirwere chinogona kukonzera rufu-uye njodzi inowira kune varwere vanovashandisa kwenguva refu kana vane chirwere chemwoyo. Kune dzimwe NSAID dzinotakura hutano hwemwoyo kupfuura dzimwe, uye zvakakosha kuti iwe utaure nachiremba wako pamusoro pezviratidzo zvako zveArthritis uye nhoroondo yako yega kana yemhuri yehutano hwemoyo uye zvinokonzera njodzi. Mishonga inorayirwa mishonga inonzi Vioxx yakabviswa pamusika ichi chikonzero.
Kuora kweiyo: Kunyange maitiro anowanzoitwa neNSAID anoshandiswa pamamiriro maduku anogona kuita kuti hosha yakaremara iwedzere ( kukurumidza kushaya simba renal .) Munyika yose inofungidzirwa kuti vanhu vanosvika mamiriyoni 2,5 vanonzwa kusakundikana kwekushaya ropa nekuda kweNSAID gore negore.
Mazano ekushandisa kusachengeteka kweNSAIDs
Iyo FDA inokurudzira kuti kuitira kushandiswa kwakachengeteka kweNSAID, mishonga inofanira kutorwa:
- Sezvakanyorwa
- Pamusana wepamusoro purogiramu inogona kuitika
- Nokuda kwenguva pfupi yakadikanwa
Zvakataurwa kuti vanhu vanogara pasi-vanorondedzera kushandiswa kwe-over-the-counter NSAIDs. Kutsvakurudza kwakawana kuti vanhu vasingatauri pamusoro pe-the-counter NSAID kushandisa kuti vatende kuti mishonga haina kukosha nokuti inowanikwa pasina mushonga. Izvi hazvisi chokwadi uye ndeimwe chikonzero (pane vakawanda) nei vanhu vachifanira kuita chiremba wavo kuziva chero kupfuura-the-counter kana zvimwe zvokudya zvinowedzera zvinotora.
Kukundikana kuzivisa chiremba we-over-the-counter kushandiswa kwemishonga ndeimwe yezvikonzero izvo dzimwe nguva vanhu vanopedzisira vachishandisa madhiragi maviri munharaunda iyi kunyange zvazvo inogona kuva yengozi.
Kutora NSAID mbiri mbiri kune ngozi
Iyo ngozi yakawedzerwa inobatanidza nokutora NSAID mbiri inokosha. Kuongorora kwekare kwakabudiswa muEuropean Journal of Clinical Pharmacology yakagumisa kuti njodzi yekushandiswa kwakanyanya kwemishonga inokonzera kukuvadza chiropa uye kusakundikana kwekushaya renal kwakapetwa kanomwe kusvika kanomwe mumatambudziko akataurwa ekushandisa kamwechete kamwe kweNSAIDs mbiri. Asi kunyange nekuziva izvi, njodzi inoramba iripo. Chidzidzo che 2017 chakawana kuti pakati pevakuru vakwegura vanotora NSAIDs, kushandiswa kwakashata kwakaonekwa kupfuura makumi manomwe.
Usarega izvozvo zvichiitika kwauri. Shandisa NSAID zvakachengeteka uye zvakakodzera. Kana uchitotora chirongwa cheNSAID, chengorora nachiremba wako usati watora chero mishonga ye-anti-the-counter.
Zvinodhaka Zvinoshandiswa seNSAIDS
Kuti urege kutora zvinodarika imwe NSAID, zvakakosha kuziva kuti ndeapi madhiragi akabatanidzwa mukirasi ino. Zvakakoshawo kuziva kuti mishonga yemutambo inogona kutengeswa pasi pemazita akawanda emhando dzakasiyana. Semuenzaniso, ibuprofen ndiyo mishonga inowanikwa muna Advil, Motrin, Nurofen, nevamwe. NSAID inogonawo kusanganiswa neimwe mishonga.
Kune matatu mitatu mikuru yeNSAIDs. Izvi zvinosanganisira salicylates (zvose zvakasarudzwa seAspirin asiri-acetylated,) NSAIDs dzetsika dzakadai (Advil,) uye COX-2 inhibitors, dzakadai seCelebrex. NSAID dzinowanzoshandiswa kurapa arthritis dzinosanganisira:
- Actron (ketoprofen)
- Aleve (naproxen)
- Anaprox (naproxen)
- Ansaid (flurbiprofen)
- Arthrotec (diclofenac ne misoprostol)
- Aspirin (acetylsalicylic acid)
- Advil (ibuprofen)
- Cataflam (diclofenac potassium)
- Celebrex (celecoxib)
- Clinoril (sulindac)
- Daypro (oxaprozin)
- Disalcid (salsalate)
- Dolobid (diflunisal)
- Feldene (piroxicam)
- Ibuprofen (mazita emagetsi anosanganisira Motrin, Advil, Mediprin, Nuprin, Motrin IB)
- Indocin (indomethacin)
- Ketoprofen (mazita emagetsi anosanganisira Orudis, Oruvail, Actron, Orudis KT)
- Lodine (etodolac)
- Meclomen (meclofenamate sodium)
- Mobic (meloxicam)
- Motrin (ibuprofen)
- Nalfon (fenoprofen)
- Naprelan (naproxen)
- Naprosyn (naproxen)
- Naproxen (mazita emagetsi anosanganisira Naprosyn, Aleve, Naprelan, Anaprox)
- Orudis (ketoprofen)
- Oruvail (ketoprofen)
- Ponstel (mefanamic acid)
- Relafen (nabumetone)
- Tolectin (tolmetin sodium)
- Tora (choline magnesium trisalicylate)
- Voltaren (diclofenac sodium)
Pasi Pano paKutora Zvakawanda Kupfuura NSAID
Kutora zvinodarika imwe NSAID hazviiti kuderedza kuora kwekutambura, asi zvinonyanya kuwedzera kungozi yako yemigumisiro inowanzoonekwa uye kusagadzikana kwakaipa. Izvozvo zvakati, vanhu vazhinji kwazvo vanoguma vachishandisa zvinopfuura imwe yemishonga iyi panguva. Chikamu chechinetso ndechokuti mishonga iyi inowanikwa zvose nemirairo uye kupfuura-the-counter, uye kana chiremba wako asingazivi mishonga isingabvumirwi iwe uri kutora, kukanganisa kunogona kusaonekwa.
Mukuwedzera pakupindirana kune NSAIDs, pane zvakawanda zvinogona kuipa migumisiro uye kuwirirana pakati pemishonga vanhu vanoshandisa arthritis. Nzira yakanakisisa yekuderedza mukana wako wekukanganisa kwakaoma ndeyokukurukurirana zvakanakisisa mishonga imwe neimwe yauri kutora pamwe chete nachiremba wako uye wemhizha yako. Nezvikanganiso zvechiremba zvichitengesa sechitatu chinokonzera kukonzera rufu muUnited States, inobhadhara kuchengeta.
> Sources:
> Kasper, Dennis L .., Anthony S. Fauci, naStefano L .. Hauser. Harrison's Principles of Internal Medicine. New York: Mc Graw Hill yembudzi, 2015. Print.
> Luciano, R., uye M. Perazella. NSAIDs: Zvakanaka zvepfungwa dzekutsvaira (Acute Renal Failure). UpToDate . Updated 03/01/17.
> Sostres, C., Gargallo, C., uye L. Angel. Nonsteroidal Anti-Inflammatory Drugs uye Pamusoro uye Kumucheto Kwemakumbo Mucosal Damage. Arthritis Research uye Therapy . 2013. 12 (Suppl 3): S3.