Zvingaita sezvisinganzwisisiki kuverenga kuti utachiona hweHIV hunogona kukonzera kukwegura kusati kwasvika, asi kunoratidzika ndeyechokwadi. Uyezve, kukwegura kusati kwaitika hakusi nyaya yeHIV inokonzera zviratidzo zvinowanzowanikwa kune vakwegura vakuru. Pane kudaro, hutano huzhinji hwevanhu vane hutachiona hweHIV hunotaridzika hwakafanana neyevanhu vasina HIV vane makore anoda kusvika gumi nemashanu.
Zvimwe zvezvinetso zvehutano zvakwegura zvekukwegura izvo zvinoitikawo mberi kune vechidiki vane HIV zvinosanganisira:
- Matambudziko Okufungisisa - HIV inogona kutungamirira kumatambudziko nemagariro ekufunga, kuyeuka, uye kurasikirwa kwehuropi.
- Bhuti Fragility - Vanhu vane HIV vane huwandu hunopfuura huwandu hwehupombwe hwehutachiona uye fractures.
- Chirwere cheshuga - Chirwere cheshuga chinowanzowanikwa kune vanhu vane HIV, zvisinei kuti hazvizivikanwe kuti zvinokonzerwa nehutachiona uye zvakadini zvinobva pamigumisiro yeHART .
- Mwoyo Yehutano - Chikamu pamusana pekuchinja kwehuwandu hwemishonga inokonzerwa nemishonga inokonzerwa neHIV, vanhu vane HIV vane pangozi yekuwedzera kwehutano hwehutano uye mamwe matambudziko emwoyo.
- Ipi Kusingakwanisi - Kuwedzerwa kwepfungwa yekushaya kwepfungwa kunokonzerwa nemigumisiro yakananga yechirwere uye kuwedzerwa kunzwisisika kune zvirwere izvo zvisingaiti zvakakanganisa maitsvo - akadai sehepatitis .
Vanhu vazhinji vane HIV vane imwechete kana yakawanda yemamiriro aya ekukwegura nguva isati yakwana - chimwe chinhu chinonzi polypathology .
Kunyange zvazvo polypathology inowanikwawo kune vanhu vakuru vakwegura vane HIV, inowanzoenzaniswa nemakore gumi nemashanu apfuura kune vanhu vane utachiona hweHIV - mune vanhu vane makore anopfuura makumi mana makumi maviri nemashanu pane vasina makore makumi maviri nemashanu vari vasina kuonekwa.
Kukwegura kusati kwaitika kunogona kuitika kune vane HIV vane hutachiona kana kuti havasi kutora mishonga inorwisa mabhakitiriya.
Kutaura zvazviri, mamwe mapoka emishonga inorwisa mabhakitiriya anogona kuita kuti zviratidzo zvekukwegura zvisati zvapera.
Nei HIV inokonzera Kusakara Kwokutanga?
Pane zvikonzero zvakawanda zvekuti sei HIV inokonzera kukwegura kusati kwasvika. Zvimwe zviviri zvakanyatsotsvakurudzwa zvakanyanya mitochondrial toxicity uye immunosenescence.
Mitochondrial toxicity inofungidzirwa kuti inokonzerwa kunyanya nekushandiswa kweNRTI , asi inoratidzikawo kuitika kune varwere veHIV vasingatori boka iroro remishonga.
Mitochondria ndiyo nzvimbo dzinoshandiswa masero - dzinoita imwe yemakemikari miviri yedu inoda kuramba ichienda. Mune vanhu vanotambura nemitochondrial toxicity, zvinyorwa izvi zvishomanana zvinotanga kupfiga uye zvisingabatsiri. Mitochondrial toxicity yakabatanidzwa nehuwandu hwezviratidzo zvekukwegura kusati kwasvika, kusanganisira zvinetso zve insulin uye lipodystrophy .
Immunosenescence inoreva kuora kwemasimba ezvirwere anowanzoitika nezera, asi izvo zvinoitika nokukurumidza kune vanhu vane HIV. Inokonzera kusununguka kwezvirwere pamwe nekugara kusingaperi kwekuvhiringidza kunogona kuva nemigumisiro yakaipa pahutano hwehutano.
Kuderera kwepamusoro-soro zvakare chiratidzo chekwegura muvanhu vakuru vasina HIV. Zvisinei, zvinofungidzirwa kuti nguva dzose kushandiswa kwemasimba ezvirwere neHIV ndeimwe yezvikonzero nei zvichiitika muhutano hwehutachiwana pahuduku.
> Sources:
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> Changes L, Andres M, Sadino J, Jiang CS, Nakama H, Miller E, Ernst T. Zvinokonzerwa neapolipoprotein E 4 neAIDS pane cognition uye brain brain: antagonistic pleiotropy uye kusakara kwehupombwe. Neuroimage. 2011 Oct 15; 58 (4): 1017-27.
> Paik IJ, Kotler DP. Kuwandisa uye pathogenesis yechirwere cheshuga inotapurirwa nehutachiona hweHIV. Best Pract Res Clin Endocrinol Metab. 2011 Jun; 25 (3): 469-78.
> Maagaard A, Kvale D. Mitochondrial toxicity mune varwere vane utachiona hweHIV zvose uye kubva kune antiretroviral maitiro: chirongwa chinoramba chiripo kana chakasiyana? J Antimicrob Chemother. 2009 Nov; 64 (5): 901-9.
> Rickabaugh TM, Kilpatrick RD, Hultin LE, Hultin PM, Hausner MA, Sugar CA, Althoff KN, Margolick JB, Rinaldo CR, Detels R, Phair J, Effros RB, Jamieson BD. Izvozvo zvinokonzerwa nehutachiona hweHIV-1 uye kukwegura paineive CD4 T-seli: kuwedzera uye kusiyanisa mararamiro ekutadza. PLoS One. 2011 Jan 26; 6 (1): e16459.