Kune miviri miviri mikuru yemakumbo emakumbo: izvo zvinotanga muuropi (pakutanga) uye izvo zvinopararira kubva kune kenza pane imwe nzvimbo mumuviri (metastasis). Zvirwere zvepfungwa zvakakosha, zvakadai seglioma, dzinowanzoitika zvishoma, uye kana dzichiita, dzinonyanya kuipa (kanzira). Chirwere chinotyisa chinongoita masero kana chikwata chekenza masero anoramba achikura; hazviiti chero chinhu kunze kwekudyisa muviri kuitira kuti zvikure.
Gliomas ndiyo inoumba boka guru rezvikamu zvepfungwa zvepfungwa. Kune marudzi akasiyana-siyana egliomas: astrocytomas, iyo inokura kupi zvako muuropi kana musipinha; ubongo hunokonzera gliomas, iyo inomuka muchikamu chakadzika cheuropi; ependymomas, iyo inowedzera mukati meuropi, muchigadziko chemhepo, uye oligodendrogliomas, izvo zvinowanzokura mumucherechedzo (zvisingawanzorevi, zvinomiririra 3% yezvose zvinokonzera zviputi zvepfungwa). An advanced astrocytoma inonzi glioblastoma; idzi dzinomiririra 23% yezvikamu zvose zvepfungwa dzakakosha.
Statistics
Maererano neAmerican Brain Tumor Association, maitiro ehupfungwa ekutanga anowanikwa pachiyero che12,8 pavanhu 100 000. Kunyange zvazvo vanhu vezera ripi neripi vanogona kukura uropi hwehupfungwa, dambudziko racho rinoratidzika kuva rakajairika muvana vane makore 3 kusvika ku12 uye kune vanhu vakuru vane makore makumi mana kusvika makumi manomwe. MuUnited States, vanenge 2 200 vaduku vasati vava nemakore makumi maviri vanoonekwa kuti gore negore zvinokonzera uropi .
Munguva yakapfuura, vanachiremba vakanga vasingambofungi nezvemakumbo europi kuvanhu vakwegura. Pamusana pekuwedzera kukuziva uye nzira dzakanakisisa dzekutsvaga huropi, vanhu vane makore makumi mashanu nemashanu vari kuwanikwa zvino uye vanobatwa.
Zvakaoma Kuita
Mishonga inowedzera muuropi yakaoma kubata. Imwe rudzi rwemishonga ndeyekunze kwemazimbero emvura, umo maharasi inopfuurira kuburikidza neuropi kusvika kumarara.
Zvinosuruvarisa, izvi zvinoratidzira hutano hwehutano hunove hunogona kukuvadza mahara. Imwe nzira yekurapa inobviswa kubviswa kwechirwere, kana zvichibvira, kuteverwa ne chemotherapy. Zvose izvi kurapwa zvakaoma kupfuurira nekuisa ngozi kune murwere. Zvinosuruvarisa kuti, gliomas dzakawanda dzinokura zvakare shure kwekurapa.
Kune zvikonzero zvakasiyana siyana nei zvakaoma kubvisa marudzi aya emakumbo emakumbo. Mimwe mishonga haigone kupinda muuropi nekuda kwekunyanya kushandiswa kwemuviri (kunonzi ropa-brain brain ). Mamwe matumbuka akapararira mukati (kuisa mukati) mavara anenge akavapoteredza ane zviduku zvishoma. Matumbu akawanda ane anopfuura imwe chete yesero mavari, saka chemotherapy inotungamirirwa kune rumwe rudzi rwechiremera mumutsara haigoni kuuraya mamwe masero.
Anoshushikana Nezvechirongwa Chetsika
Nzira itsva dzekurapa uropi hwemakumbo dziri kuongororwa, kusanganisira kuchinja marapirwo akange aripo uye nekuvandudza nzira itsva dzekupa marapirwo.
Kuwana chemotherapi mishonga yakapfuura ropa-brain cointer, somuenzaniso, vatsvakurudzi vari kuwedzera dhizi uye kuisira mishonga zvakananga mumidziyo yeropa yeuropi. Imwe nzira itsva inoisa chemotherapy zvakanaka panzvimbo yechipfuva. Mushure mokuvhiyiwa, zviduku zveplastiki zvigadzirwa zvinyorwa zvinogona kuiswa munzvimbo iyo mutezo waiva.
Aya mahwendefa anosunungura chemotherapy mishonga ipapo.
Chimwe chinhu chakafanana chinogona kuitwa neradio ray. Mushure mokunge bundu racho rabviswa, bhoron rinopurirwa rinosungirwa mumucheka wakasara nechirwere. Bhozoni izere nemirairo yemvura, uye pamusoro pevhiki inouya, inopisa mavara ari pedo neyo kuti iuraye mamwe masero emukenza anoramba aripo.
Antiangiogenesis
Vatsvakurudzi vari kutarisa kuporesa kwepamuviri kubva kune dzimwe nzvimbo dzinofadza. Chimwe chezvinhu izvi ndeye antiangiogenesis. Izvi zvinoreva kuderedza ropa rekupa kumarara kuitira kuti zviitike zvisingakure, zvichanyangarika uye zvichafa. Chimwe chidzidzo chakaedza mishonga inorwisa antioangiogenic, Thalidomide, nevarwere vakanga vane gliomas yakakomba yakanga isina kupindura mazairo uye / kana chemotherapy.
Rimwe gore mushure mokutanga mishonga, 25 muzana yevarwere vakanga vachiri vapenyu, kunyange zvazvo mvere dzavo dzakanga dzichiri kukura. Vatsvakurudzi vakaratidza kuti zvichida Thalidomide inogona kuedzwa mune varwere vachangobva kuongororwa, uye inosanganiswa ne-radiation uye chemotherapy.
Kushandisa Immune System
Imwe nzira yekurapa kweglioma iri kuongororwa iri kushandisa muviri wemuviri wechirwere kuti urwise chiremera. Vatsvakurudzi vari kuongorora vakatora varwere 19 vane gliomas, vakagadzira vachengeti kune mumwe nomumwe achishandisa maitiro ake, uye mushure mekunge chirwere chichikurudzira chigadzirwa chemunhu wese chemasero eropa (anodzivirira utachiona). Makumi nemakumi manomwe evarwere vakaratidza mhinduro kumushonga. Muchiremba vasere, vatsvakurudzi vanogona kuona mhinduro pa x-ray, uye vashanu vevarwere chaizvoizvo vakavandudzwa. Vamwe vevarwere vakararama kwenguva yakareba makore maviri mushure mekurapa.
Poliovirus
Iro rinogona kurapwa rakagamuchirwa nehuwandu hwemashoko ndiko kushandiswa kwe poliovirus kurwisa gliomas. Vatsvakurudzi vakaona kuti poliovirus ine kukokwe kwechisikigo kune chemakemikari inowanika pane zvinotyisa zvinokonzera. Zvisinei, sezvo vakanga vasingadi kukonzera chirwere cheporiyo, vakashandisa genetic engineering kuti vatore chikamu chetachiona chinokonzera kupisa (rhinovirus) ndokuchiisa mu poliovirus. Izvi "zvakachenesa" chikamu chinokonzera zvirwere che poliovirus. Vatsvakurudzi vakasika gliomas mumakonzo, uye vakaedza hutachiona hutsva mumakumbo. Vaifara kuona kuti maronda acho akabviswa. Nhanho inotevera ichava nekugadzira chidzidzo chekutsvakurudza kuongorora hutachiwana hwevanhu.
> Sources:
> American Brain Tumor Association. Chokwadi uye Nhamba.
> American Society For Microbiology. "Pasiyovirus inogadziriswa inokonzera kurwadziwa kweuropi." Nyaya yekubudiswa, May 22, 2001.
> Fine, HA, Figg, WD, Jaeckle, K, et al. (2000). Phase II muedzo weAn antiangiogenic agent Thalidomide kune varwere vane gliomas yakakwirira yepamusoro. J Clin Oncol, Vol. 18, Kwete 4, peji 708-715.
> Flowers, A. (2000). Utumbo hwebhondi mumunhu mukuru. Kanzura Kudzora, Vol. 7, Nha. 6, mapeji 523-538.
> National Cancer Institute. Zvamunoda Kuziva Nehutano Zvirwere.
> Sloan, AE, Dansey, R., Zmorano, L., Barger, G., Hamm, C., Diaz, F., Baynes, R., Wood, G. (2000). Adoptive immunotherapy kune varwere vanowanzova malignant glioma. Neurosurg Focus, Vol. 9, Nha.
> Wake Forest University Medical Center. "Denga Rekutanga mu > nyika > kuita hutsva hupombwe kurapa." Nyaya yekubudiswa, May 25, 2001.