Osteoarthritis inowanzozivikanwa seyokufuka-uye-kusvimha arthritis. Zvisinei, vatsvakurudzi vari kuwana iye zvino kuti hazvisi zvachose pamusoro pekasa rakasakara. Kune zvimwe zvikamu zvekubatana kwemajoini, zvakadai se subchondral bone, iyo inobata basa rinokosha mu osteoarthritis.
Chii chinonzi Subchondral Bone?
Subchondral bone ndiyo yakatsetseka yemafupa pasi payo pasi pekateti mubatanidzwa.
iyo -chondral inoreva martilage, apo iyo inotangira sub ingano pasi. Subchondral bone inotyisa inobata nhengo dzinorema.
Iine mishonga yakawanda yeropa inopa iyo michina uye oksijeni uye inotora marara. Sezvo cartilage isina ropa rayo, inoshamwaridzana nevascularized subchondral bone ndiyo inoita kuti maronda ashandiswe. Iyi midziyo inopa hafu ye hydration, oxygenation, uye glucose yekateti. Utano uye basa re subchondral bone richaita musiyano muhutano hwehutakiti huri kumusoro kwahwo.
Chii Chinoitika muOsteoarthritis
Mu osteoarthritis, the subchondral bone inowedzera kupfuura yakawanda. Uchapupu hwakaratidza kuti kuoma kunotanga kuitika mushure mekunge martilage inotanga kupfeka-zvinoratidza kuti subchondral bone inobatsira pakugadzira osteoarthritis. Zvidzidzo zvakawana kuti pamberi peosteoarthritis inowedzera ipapo inogona kuwedzera kuwedzera kwekudzoka kwe subchondral bone, sezvinoyerwa nekatsva.
Mamwe maitiro ari kuita kuti pfupa rikurudzirwe kuti ridiwe kuputsa uye kugadzirisa pacharo. Izvi zvinowanzobudisa zvinowanikwa ne-michina yeiyo metabolism muropa iro rinopa zvose mapfupa uye maronda.
Subchondral bone attrition ndeyekupeta kana kuora mwoyo kwepamusoro.
Inowanikwa mumabvi ekutanga osteoarthritis uye kuvapo kwayo kunofanotaura kana kurasikirwa kwekatekete kuchakura uyewo kana imba yemabvi ichange ichinyanya kumira. Subchondral bone marrow edema-like zvipembenene uye subchondral bone maitiro anoonekwa pamwe chete. Imwe nyanzvi ndeyekuti kupfeka uye kubvarura pamabvi kunokonzera michina-fractures iyo inogara iri nguva dzose yekugadzirisa. Ichi chiitiko chinogadzira enzymes uye mapuroteni angave ane zvimwe zvinowedzera pane pedtilage yakatarisana.
Vatsvakurudzi vakawanawo kuti subchondral bone tissue inokonzera makirokine akawanda akafanana uye kukura zvinhu (mapuroteni) zvinogona kukonzera kuvhiringidza uye kuchinja muhututi. Chaizvoizvo chiri kuitika uye kuti makemikari angave ari anonyanya kutarisirwa anoda kutsvakurudza mberi. Pasinei nokuti subchondral bone inoshandiswa ndiyo inokonzera kurasikirwa kwekatekete kana kuti vanoitevera iyo mubvunzo wekuku-kana-ye-yai kuti uwedzere kutsvakurudza. Chii chinouya pakutanga? Pane imwe nzira inotyaira zvose? Ndizvo chaizvoizvo zvinokonzerwa nokupfeka-uye-kusvimha kana kune chimwe chikonzero chikuru?
Dzimwe Subchondral Bone Mamiriro eOsteoarthritis
- Subchondral Cyst : Izvi zvinowanzoonekwa mune osteoarthritis, iyo igesi yakazara-yegasi inotambanudza kubva pajoka. Icho chinhu chinowanikwa zvakajeka pa X-ray asi hazvirevi kudhakwa kana mamwe marapirwo.
- Subchondral Sclerosis : Izvi zvinowedzera kuwanda kwepafu kana kuwedzera mu subchondral layer, yakaonekwa pa X-ray ye osteoarthritis. Icho chimwe chezviratidzo zvemashoko zvechiitiko chacho.
Sources:
> Biochemical and mechanical properties of subchondral bone mu osteoarthritis. Biorheology. 7/26/2004. Inotsvaga Radiology: October 2000 - Bhuku 35 - Nyaya 10 - pp 581-588
Mazuva ano Rheumatology. Bhuku 13, Nhamba 1. March 2003. http://www.springerlink.com/content/j0d9m9yak10085hc/
Frank W. Roemer, et. al. "Subchondral bone marrow lesions inowirirana zvikuru, uye inofanotaura subchondral bone maitiro kwenguva refu: MOST kudzidza." Osteoarthritis Cartilage 2010 Jan; 18 (1): 47. Yakabudiswa paIndaneti 2009 Sep 10. nei: 10.1016 / j.joca.2009.08.018