Alpha-ketoglutaric acid ndiyo chinhu chinowanikwa zvakasikwa mumuviri womunhu. Uyewo inowanikwa muzvokudya zvinowedzera kudya, alpha-ketoglutaric acid inotora basa rinokosha mumutambo weKrebs (aitevedzana emakemikari anoshandiswa anobatanidzwa mukugadzira muviri kwesimba). Alpha-ketoglutaric acid inowedzera inonzi inopa hutano hwakasiyana-siyana.
Alpha-ketoglutaric acid inowanikwawo munyuro yemunyu, sechinhu chinonzi alpha-ketoglutarate.
Alpha-ketoglutarate inobatanidzwa pakuumbwa kwe glutamine, amino acid inoda kuti purotini ye synthesis uye kushanda zvakanaka kwemuviri wemuviri.
Zvishandiso
Alpha-ketoglutaric acid inowanzotaurwa kuti kuwedzerwa mitambo inoshanda. Vamwe vashandisi vese vanorapa mushonga vanoti kushandiswa kwe alpha-ketoglutaric acid kunogona kubatsira kukurudzira kugadzirwa kwemuviri wemapuroteni, kusimbisa shuga yeropa mukati mekurovedza muviri, uye kuvandudza kushanda kutsungirira.
Mune marapirwo akasiyana-siyana, alpha-ketoglutaric acid inonziwo kubatsira kune zvinotevera zvinetso zveutano:
- mabhakitiriya zvirwere
- cataract
- kidyo chirwere
- mbiriso zvirwere
Batsirwa
Kunyangwe kutsvakurudza pamusoro pehutano hweAlpha-ketoglutaric acid ishoma kwazvo, imwe tsvakurudzo yekutanga inoratidza kuti alpha-ketoglutarate inogona kupa humwe hutano hwehutano. Pano tarisa pane zvimwe zvitsva zvinowanikwa kubva kune zvidzidzo zviripo:
1) Hemodialysis
Alpha-ketoglutarate inogona kuva yeimwe rubatsiro kune vanhu vanoita hemodialysis.
Mune chidzidzo chakabudiswa mumagazini yeNefron muna 1996, vatsvakurudzi vakawana kuti kutungamirira kusanganiswa kwe alpha-ketoglutarate uye calcium carbonate kune hemodialysis varwere vakabatsira kukurudzira amino acid metabolism uye kuderedza hyperphosphatemia (mamiriro akaratidzwa nemaitiro asingaverengeki akakwira phosphate muropa).
2) Kuvhiya kweCardiac
Alpha-ketoglutarate inogona kubatsira kuvandudza mafungiro evhupi pakati pevarwere vari kuitirwa chirwere chepfungwa, maererano nechakaitwa muna 1998 kubva kune Annals of Thoracic Surgery . Chidzidzo chacho chaibatanidza vanhu 22 vane hutano hwehutano husati vasati vaita chirwere chepfungwa. Pakati pavarwere ivavo, vanhu 11 vakagamuchira kuvharirwa kwema alpha-ketoglutarate kweawa imwe mushure mekuvhiyiwa kwavo. Chidzidzo chekudzidza chinoratidza kuti alpha-ketoglutarate inogona kusimudzira ropa kuyerera muitsvo.
3) Zuva refu
Chidzidzo che2014 chakabudiswa muChimiro chinoratidza kuti alpha-ketoglutarate inogona kuratidza chivimbiso mukuwedzera kwenguva refu. Mune miedzo ye nematode worm Caenorhabditis elegans , vanyori vekudzidza vakagadzirisa kuti alpha-ketoglutarate inopindira kushandiswa kwemagetsi emagetsi uye inoshandisa migumisiro yezvokudya zvakaderera zvikuru mumakirori, ayo akaratidzwa kufambisa upenyu hwemamwe mhuka. Maererano nevanyori vekudzidza, alpha-ketoglutarate yakasimbisa hupenyu hwemhonye inobatwa ne50% pamusana pekutonga kusina kutenderwa. Chimwe chidzidzo chinodiwa kuti uone kuti zvii zvinenge zvichange zvichange zvakaita muvanhu.
Caveats
Pamusana pokushayikwa kwekutsvakurudza, zvishomanana zvinozivikanwa nezvekuchengetedzwa kwenguva refu kana kushandiswa nguva dzose kwezvinyorwa zvine alpha-ketoglutaric acid.
Zvisinei, kune kumwe kunetseka kuti kushandiswa kweAlpha-ketoglutaric acid kunogona kuvhiringidza sopu uye / kana kukanganisa mudumbu.
Zvakakosha kuchengetedza mupfungwa kuti zvidimbu hazvina kuongororwa kuchengetedzwa uye zvokudya zvekudya zvinowanzosaregererwa. Mune zvimwe zviitiko, chigadzirwa chacho chinogona kutakura dhesi dzinopesana nemari yakatarwa yemiriwo imwe neimwe. Mune dzimwe nguva, chigadzirwa chacho chingave chakasvibiswa nezvimwe zvinhu zvakadai sesimbi. Uyewo, kuchengeteka kwezvokuwedzera mumadzimai ane pamuviri, vanaamai vanoyamwisa, vana, uye avo vane zvirwere kana avo vari kutora mishonga haisati yasimbiswa.
Iwe unogona kuwana mamwe mazano ekushandisa mashandisiro pano .
Alternatives
Mamwe mimwe mishonga yemasikirwo inogona kuve yeimwe shanduro mukuvandudza mitambo. Semuenzaniso, kumwe kutsvakurudza kunoratidza kuti branched-chain amino acids inogona kubatsira kuvandudza kushanda kwemuviri nekudzivirira kuneta munguva refu yekurovedza muviri.
Mukuwedzera, phosphatidylserine inowedzera kuwanikwa yakawedzerwa kuwedzera simba rekudzidzira, pamwe nekuderedza kusuruvara kwemisumbu uye kudzivirira pakusana kwekuwedzera kwemazinga e-cortisol (hormone yakabudiswa munguva yekudzvinyirira) iyo inowanzokonzerwa nokuwedzeredza.
Panewo humwe humwe uchapupu hunoratidza kuti chisiki chinogona kusimbisa kushanda mukukwirira kwepamusoro-soro, zviitiko zvenguva pfupi (zvakadai sekurema-kusimudza uye sprinting).
Kupi Kuti Uiwane
Inowanikwa kutenga inowanikwa paIndaneti, alpha-ketoglutaric acid inotengeswa mune dzakawanda-zvekudya zvekudya, zvinokonzera zvinodhaka, uye zvezvitoro zvinoshandiswa mune zvekudya zvinowedzera.
Shoko Rinobva
Pamusana pekutsvakurudza kwakanyanya, zvakakurumidza kuparidzira alpha-ketoglutaric acid chero mamiriro ezvinhu. Zvakakosha kuziva kuti kuzvirapa kwehutano ne alpha-ketoglutaric acid uye kudzivisa kana kunonoka kutarisirwa kwese kunogona kuva nemigumisiro yakakomba. Kana uri kufunga kuishandisa, iva nechokwadi chekuona chiremba wako.
Sources
Chin H, H, H, H, H, D, G, Diep S, Lomenick B, Vs VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. "Metabolite α-ketoglutarate inowedzera upenyu nekudzivisa ATP synthase uye TOR." Nature. 2014; 509 (7500). dx.doi.org/10.1038/nature13264
Jeppsson A, Ekroth R, Friberg P, Kirnö K, Milocco I, Nilsson FN, Svensson S, Wernerman J. "Renal nemigumisiro ye alpha-ketoglutarate nguva pfupi mushure mekugadzirisa mabasa." Ann Thorac Surg. 1998 Mar; 65 (3): 684-90.
Riedel E, Nündel M, Hampl H. "Alpha-Ketoglutarate inoshanda mu hemodialysis varwere vanovandudza amino acid metabolism." Nifuroni. 1996; 74 (2): 261-5.
Zvinonzwisisika: Mashoko anowanikwa pane ino yepaiti inoitirwa zvinangwa zvekudzidzisa chete uye haisi kutsiva mazano, kuongororwa kana kurapwa nechiremba ane chiremba. Hazvirevi kuvhara zvose zvinogona kumira, kushamwaridzana kwezvinodhaka, mamiriro ezvinhu kana zvinetso zvakashata. Iwe unofanirwa kutsvaga kurapwa nokukurumidza mune zvehutano kune chero hutano hwehutano uye bvunza chiremba wako usati washandisa mamwe mushonga kana kuita shanduko kune regimen yako.