Proton-pump inhibitors inogona kuwedzera njodzi yezvimwe zviputsi.
Muzvinyorwa zvemishonga, mashoma madhirairi akave seasina kubudirira pakugadzirisa kusuruvara seproton-pump inhibitors (PPIs) , kana mishonga yakadai se omeprazole (generic), Prevacid neNexium.
Proton-pump inhibitors inobatsira mamiriyoni eAmerica kuwana ruzivo kubva kune gastroesophageal reflux chirwere (GERD). Gastroesophageal reflux chirwere chinowanzoitika apo mudumbu inoparadzira zvinyorwa zvayo zvechidimbu zvichidzokera mudumbu, kana pombi yezvokudya, nokudaro zvichiguma nekutsamwa kana kuora mwoyo.
(Vanhu vashomanana vane ruzivo rwechirwere chechiGERD chechipiri kusvika kumashure ekuderera kunonzi sophgetic sphincter kana TLESR .)
Kune chikamu chikuru, maPIsIs akanyatsochengeteka. Zvisinei, pane kuve nokugunun'una pakati pevamwe nhengo dzevanhu vezvehutano kuti PPIs inogona kutungamirira kumapfupa emapfupa pakati pevanhu vakwegura (zvikurukuru vakadzi vakwegura vari kuwedzera mungozi ye osteopenia kana osteoporosis).
Kuwedzerwa, pane zvave zvichinetseka kuti maPPIs angangobatsira kune ngozi yekuputika kwechiuno , izvo zvinoita kuti pave nemari yakawanda, kuremara, kurwara uye kufa pamwe.
Kupararira kwePPIs kwakapararira zvakadini?
Proton-pump inhibitors zvakanyatsonaka pakuderedza kuwanda kwemashizha akachengetwa nedumbu. Zvinonzwisisika, maPPIs ari nani mukuderedza gastric acid secretion kupfuura H2 blockers, kana kuti histamine-kudzivirira mishonga, yakadai seZantac kana cimetidine.
MuUnited States muna 2009, mamiriyoni zana emamiriyoni makumi mapfumbamwe nemaviri emuPP akanyorwa.
Uyezve, gore rimwe chete kutengesa kwePPIs kunokwana $ 13,5 biliyoni.
Vanenge makumi mana kubva muzana vevanhu vakuru vekuAmerica vanoona zviratidzo zveGERD mwedzi mumwe nomumwe, uye vanhu vazhinji vari kurarama kwenguva refu yePARI kurapwa kunobvisa kuora mwoyo.
MaPPIs angabatsire sei kushaya kuputika kweropa?
Imwe nzira yakajeka iyo maPPIs anogona kuita kuti pfupa rinoputsika risvike rinosanganisa kuderedza calcium kuburikidza nehutachiona.
Kurarama kwenguva refu kwezvinodhaka izvi zvinogona kukanganisa kuvharwa kwe calcium, inoda kuvepa mapfupa, kugadzirisa, nekugadzirisa.
Heano mamwe mafungiro anotsanangura kuti maPIs anogona sei kuwedzera ngozi yefupa rakaputika.
- PPIs inowedzera kusunungurwa kwegastrin, imwe hormone yemudumbu, iyo inobvumirawo utachiona hunoita basa. Utachiona hwakavanza calcitonin uye horathy (parTH) , iyo inodzora calcium muropa uye bone metabolism.
- PPIs inogona kukanganisa zvakanyanya osteoclasts uye osteoblasts, kana masero anoputsa uye kuvaka pfupa, maererano.
- Vanhu vanogara vachiita PPI vangangodaro vawana mamwe mamiriro ezvinhu uye zvinokonzera zvinogona kuita kuti calcium kurasikirwa uye kuputika kwepfupa, zvakadai sekuwedzerwa kushandiswa kwe thiazide diuretics kana imwe chirwere chekudya. Uyezve, vanhu ava vanogonawo kunwa doro rakawanda, iyo inoshandurawo calcium kunyanya uye bone metabolism.
- Vanhu vanogara vachiita PPI vanogona kugadzirisa zviratidzo zvavo kuti vadzivise zviratidzo zveGERD saka nenzira imwechete iyo kuderedza calcium kudya.
Zvinotsvakurudzwa neUtsvakurudzo
Kwenguva yakareba, kutsvakurudza kwakabatanidza kushandiswa kwenguva refu kwePPI uye mapfupa emapfupa akavhenganiswa. Zvakanga zvisati zvaitika muna 2010 kuti takaona yekutanga kunyatsodzidza kunyatsoongorora kuwirirana pakati pezvirevo zviviri izvi.
Kushandisa nhoroondo kubva kuHarare's Health Initiative, kuongorora kwehutano yenyika kuongorora 161 808 vakadzi vanobva mumamiriro akasiyana-siyana akwegura pakati pe50 ne79, vatsvakurudzi vakagadzirira chiitiko chaizotarisa chakatarisa ushamwari pakati penguva refu inoshandiswa kwePPI, pfupa rinoputsika uye pfupa remaminetsi (imwe chiratidzo bone utano).
Maererano nemigumisiro yenyaya ino, kushandiswa kwenguva refu kwePPI kwakabatanidzwa nehuwandu hwehutachiona hwekliniki, forearm, maziso uye zviputi zvachose. Zvisinei, kushandiswa kwenguva refu kwePPI kwakanga kusingabatanidzwi nehuwandu hwekuputika kwechiputi kana kuderera kwemafupa emagetsi.
Tsvakurudzo Ino Inorevei Kwauri?
Kana iwe wakwegura uye chiremba wako akakuratidza iwe kwenguva refu yePARI chirwere chekuregererwa kubva kuGERD, iwe unofanira kuramba uchitora mishonga iyi uye unosangana nachiremba wako nguva dzose.
Kushushikana kusina kukwana pamusoro pePPIs kunokonzera kuputsika kwepafu hakufaniri kukumisa kuti urege kuwana mimba yekudzikinura yaunoda.
Zvisinei, chiremba wako anofanirwa kuongorora kana iwe unonyatsoda PPIs uye, kana zvakadaro, chinangwa chekupa huwandu hwehuwandu hunoshandiswa. Uyezve, paunenge uri paPPIs, unofanirwa kuve nechokwadi kuti udye kudya kwakakwana kunokwana calcium yakakwana. Chiremba wako angada kugovera iwe calcium supplement.
Kana iwe wave uchigara uchitora-the-counter PPI kuti urove kupisa kwemwoyo asi usati wamboona chiremba wechinetso ichi, iyo pfungwa yakanaka yekuita musangano uye kuongororwa.
Sources:
"Proton Pump Inhibitor Kushandisa, Hip Fracture, uye Kuchinja mu Bone Mineral Density mu Postmenopausal Women: Zvakawanikwa kubva kuHome's Health Initiative" neS SL Grey uye vanyori vanyori vakabudiswa muChinyorwa cheInternal Medicine muna 2010.
"Kushamwaridzana Kwemazuva Ekupedzisira Purotoni Pump Inhibitor Therapy Ne Bone Inoputika uye Migumisiro Yokuswa kweCalcium, Vitamin B12, Iron, uye Magnesium" naT Ito uye RT Jensen muNhasi Gastroenterology Reports muna 2010.