Zviratidzo, Makomborero uye Migumisiro Yechipatara
Phosphodiesterase-4-inhibitors (PDE4) yakadai seDaliresp (roflumilast) inhengo itsva yezvinodhaka zvechirwere chinokonzera kupora zvirwere (COPD ) nezvimwe zvirwere zvemapapu. Iyi mishonga inoita kuti isabhedzere kuputika mumhepo yevanhu kune vasingadi kurwara. Daliresp (roflumilast) ndiye chete PDE4 inhibitor iye zvino anogamuchirwa muUnited States.
Iyo Phosphodiesterase-4-Inhibitors Inoshanda
Mishonga yakadai seDaliresp work inodzivisa migumisiro ye phosphodiesterase 4, enzyme inobatsira kuputsa molecule inonzi cyclic adenosine monophosphate (cAMP.) Kuwedzera kunowedzera mumusasa (nokuti hausi kuputsika ne phosphodiesterase 4) kunoita kuderedza kupisa mapapu pakati pezvimwe zvinhu.
Chiratidzo cheCOPD chisingagumi kuputika, uye vanhu vane COPD uye asthma vanowanzova nekuwedzererwa kwePDE4 kunobatsira pakuputika uku.
Nokuderera kuputika, mishonga yakadai seDaliresp inogona kuderedza kubhurwa kwepamusoro kwehuwandu hwechimiro cheCOPD, uye kuderedza kugadziriswa kwemhepo.
Chii Chinonzi PDE4 Inhibitor Do?
Nokuwedzera mazana ematunhu uye kupera kwechirwere, PDE4 inhibitor inogona kuderedza nhamba yekuwedzera kweCOPD nekuvandudza basa remapapu. Nekuwedzera kweMAMP, vanogonawo kukonzera mamwe maronchodilation.
Zvakakosha kuziva kuti mishonga iyi haigadziri mapapu, inoshanda panzvimbo payo kuderedza kuvhiringidza uye kudzivirira zvimwe kukuvara nekuwedzerwa kwezviratidzo.
Mamiriro Ezvo Apo Daliresp (Roflumilast) May Ngashandiswe
Mamiriro ayo Daliresp angashandiswa anosanganisira:
- COPD
- Asthma
- Psoriasis
- Psoriatic arthritis
Inoshandiswa Rini?
PDE4 inhibitors yakadai seDaliresp inoshandiswa kuvandudza mapapu mukati mevanhu vane COPD vakagadzikana avo vanorwisana nehutano hwakanaka.
NeCOPD vanoita sevanobatsira zvikuru kune vanhu vane chirwere chisingaperi chisingarapiki vanowanzowedzera kuipa kwechirwere chavo .
Sezvo izvi zvinodhaka zvinoshanda pazvisingagumi kuzvirumbidza, hazvisati zvashandiswa mukurwisa zvakanyanya kweCOPD kana chirwere cheputi, asi panzvimbo yekuchengetedza kusingaperi kwechirwere.
Kusiyana nehutachiona hunoputika, Daliresp inongova-zuva rimwe nerimwe, mishonga yemuromo yakawanikwa kuvandudza mapapu mukati mevarwere vanobatwa ne salmeterol uye Spiriva (tiotropium.)
Mhedziso yeP PDE4 inhibitor inoratidzika kuva yowedzera ne corticosteroids.
Migumisiro Yechiri
Izvozvo zvinokonzera migumisiro ye PDE4 inhibitor dzinosanganisira kurara, kusuruvara, uye musoro. Zvinogona kukonzera kuora muviri, saka kuyerwa kunofanira kuongororwa panguva yekurapa uye kwakakonzera zviratidzo zvepfungwa kune vamwe vanhu.
Kuwirirana
Pamusana pesabolism yayo ne cytochrome P-450, PDE4 inhibitor inogona kupindira (kukura kana kuderera) mamwe mishonga uye inogadziriswa nenzira iyi, somuenzaniso, mishonga yakadai seyerythromycin, cimetidine, mapiritsi ekuberekwa kwepabonde, mamwe mishonga yokutapa, nezvimwewo.
Uyewo Anozivikanwa Se: PDE4, kusarudza phosphodiesterase-4 inhibitors
Sources:
Ferguson, G., uye B. Make. Kutungamirirwa kwehutano husingaperi hunoparadza zvirwere. Kusvika pari zvino. Updated 01/21/16.
Mulhall, A., Kurwisa, C., Ernst, N., Panos, R., naM M. Zafar. Phosphodiesterase 4 inhibitors nokuda kwekurapwa kwechirwere chisingaperi chepemmonic: chirongwa chemazuva ano uye kuwedzera mishonga. Expert Opinion pamusoro peInvestigational Drugs . 2015. 24 (12): 1597-611.
Reid, D., uye N. Pham. Roflumilast: kurapa kweruzivo rwechirwere chisingaperi chinoparadza zvirwere. Anals of Pharmacotherapy. 2012. 46 (4): 521-9.
US National Library of Medicine. MedlinePlus. Roflumilast. Yashandurwa 08/15/12. https://www.nlm.nih.gov/medlineplus/druginfo/meds/a611034.html