Dzidza Mavambo eMonoclonal Antibody Therapy
Monoclonal antibody therapy ndiyo inorwara kenza inorapwa . Iko dzimwe nguva kunonzi immunotherapy. Kunyange zvazvo kuvhiyiwa , chemotherapy , uye remishonga inonzi radiation zvinoramba zvakakosha kurapwa kwekenza yekoloni, monoclonal antibody therapy inowedzera kupararira kuti ishandiswe. Nyaya inowanzovhiringidzika inonzi monoclonal antibody inorapwa yekenza yekoloni ndeyeBevacizumab (Avastin), Cetuximab (Erbitux), uye Panitumumab (Vectibix).
Chii chinonzi Monoclonal Antibodies?
Monoclonal antibodies mapuroteni anowanikwa mu laboratori. Aya mapuroteni akagadzirirwa kunamatira kune nzvimbo dziri pamusoro pekenza masero uye anopindira nekukura kwavo uye kupararira. Monoclonal antibodies akafanana nemasimba anomuviri wako anowanzobereka apo iwe unotarisana nemabhakitiriya kana mavairasi, zvakadai sechando kana chirwere (influenza).
MaMonoclonal Antibodies Anoshanda Sei?
Masero mumumuviri wedu, kusanganisira masero emukenza, ane nzvimbo panzvimbo yavo inonzi receptors. Izvi zvinogadzirisa kubatsira kuti masero edu anokura sei, orega kukura, kana kuita chimwe chezvinhu izvo masero anowanzoita. Kana puroteni yakarurama inouya uye ichibatanidza (inosunga) kune yakagadzirirwa pane imwe sero, izvi zvinoita kuti sero ipindure.
Nzira yakanaka yekufunga nezvezvinogamuchirwa uye mapuroteni avo anosungira ndeyekufunga nezvekuvha uye chinhu. Bhokisi harizozaruriki pasina kona yakarurama. Nenzira imwecheteyo, mucherechedzo hauchazoiti kuti sero rikure, riparadzanise, kana kupindura kunze kwekuti "kodzero" yakakodzera kune iyo yakagadziriswa inobata pakutanga.
Uye mishonga yemasikironi ndeye "kiyi" iyo yakanyatsogadzirirwa kunamatira kune zvinogadzirwa nekenza masero.
Mienzaniso yeMonoclonal Antibody Therapies
Epidermal growth factor receptors (EGFRs) mumwe muenzaniso wezvinogamuchirwa zvinokonzerwa nemasikironi evanhu. EGFRs iripo pamasero akajairika uye masero emukenza, asi nekenza masero, izvi zvinogamuchirwa hazvisi zvisizvo.
Ikoko kunogona kuva neEGFR yakawanda kana kuti inogona kukuvadzwa kana kuchinjwa (inoshandiswa) nenzira inovabvumira kuti vapindure zvakanyanya pakuwedzera kwezviratidzo. Izvi zvinokonzera masero emukenza kukura zvakanyanya kana kukura munzvimbo dzavasingafaniri kukura.
Iyo monoclonal antibody therapies Cetuximab (Erbitux) uye Panitumumab (Vectibix) inonyatsobatanidza neEGFRs inowanika pamasero ekenza. Apo pavanosangana neEGFRs, vanovhara zviratidzo zvinokura izvo muviri wako unowanzobereka kubva pakuwana kenza dzemukenza. Izvi zvinononoka kana kudzivirira kukura kwekenza.
Kufunga nezvekuvha uye kufanana kwakakosha, unogona kufungidzira kuti Cetuximab nePanitumumab vanoita sokuti mumwe munhu akaisa gum mukivha. Chino hachigone kupinda uye musuo haugoni kuvhurwa nokuti kenza yemukati yakagadziriswa yakato "gummed up" nemaonopolisi e monoclonal. Izvi zvinoreva kuti masero emukenza haasati agamuchira zviratidzo zvinokura zvavanoda kuti varambe vachikura nekupararira.
Kugadziriswa kweMonoclonal Antibodies
Kunze kwekungovhiringidza mabasa emakumbo esero, mishonga inonzi monoclonal inogona kubatanidzwa kune chemotherapy mishonga kana radioactive mutezo (radioimmunotherapy) saka vanotora matanho ekurapa kwekenza uye kwete kumasero akajairika. Izvi zviri kushandiswa nemamwe maitiro e-lymphoma uye kenza yemazamu nemishonga inogona kuwanika kurapa mamwe maitiro ekenza.
Ndezvipi zvakashata zveMonoclonal Antibody Therapy?
Kune vanhu vazhinji, migumisiro yechirango chemonoclonal antibody therapy inosvibisa kupfuura chemotherapy uye yakafanana nemararamiro evanhu vanoita. Zvimwe zvinowanzovhiringidza zvinokonzerwa ne monoclonal antibody therapy zvinosanganisira:
- Ganda rinoputika
- Kucheka kweganda kana mikoko
- Zviratidzo zvakadai sefivha, chills, muscle aches, kuneta, uye musoro
- Diarrhea
- Nausea uye kurutsa
- Low blood pressure
Vamwe vanhu vanoita zvakakomba kune monoclonal antibody therapy. Mamwe matambudziko makuru akanganisa chiremba wako kuti amire monoclonal antibody therapy inosanganisira:
- Ropa rakaderera zvikuru rinorema
- Zvinetso zvemwoyo zvinosanganisira kusagadzikana kwepfungwa, kusagadzikana kwemoyo, uye kuwedzerwa kungozi yekurwadziwa kwemoyo
- Kuderera kwema magnesium, potasium, kana calcium muropa rako, izvo zvinogona kukonzera zvinetso zvehutano zvakakomba
- Dzakakomba ganda rinokonzera kutapukira
- Matambudziko ekubvisa
- Kushandurwa kwakananga kumusanganiswa kunosanganisira kupfupika kwefemhepo, kuputika, kutya, kushaya simba, chizivi, kutadza kuona, kusuruvara, kana kurwadziwa kwepfupa kana kuomeswa
Nenzira, kana zviitiko zvakakomba zvikaitika, zvinowanzoitika nokukurumidza, apo uri kuwana mishonga pane kliniki yako yekuchengetedza kenza. Izvi zvinoreva chiremba wako uye mukoti achakucherechedza iwe uye achakwanisa kumira kuvharwa kana zvichidiwa uye kukupa chirwere chekurumidza.
Ndingaita Sei Kuti Ndichengetedze Monoclonal Antibody Treatment Side Side Effects?
Zvinhu zviviri zvinonyanya kukosha zvaunogona kuita kuti uchengetedze migumisiro ye monoclonal antibody therapy ndeyekuti:
- Tora mishonga yako yese sezvaunenge wataurwa, nokuti zviri nyore kudzivirira migumisiro pane kuvabata kamwechete pavanenge vachiitika.
- Chengetedza mitsara yekukurukurirana yakazaruka neboka rako rezvechiremba. Zvinoshanda kushandisa migumisiro yemunhu mumwe chete zvingasashanda iwe. Taura nachiremba wako kana mukoti pamusoro pekusarudza kuti akubatsire kupinda mumarapirwo nemigumisiro miviri.
Usagamuchirwa kunzwa kwakashata chikamu chepanyama chekenza. Panogona kunge kune nzira yekuti chikwata chako chezvehutano chive nani kutarisira mararamiro ako. Kana uchida kubatsirwa, bvunza. Uye nguva dzose, kana uine mibvunzo ine chokuita nemigumisiro, tumira nhengo yako yezvechipatara pakarepo.
Sources
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Medline Plus. Panitumumab Injection.
https://medlineplus.gov/druginfo/meds/a607066.html
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http://www.cancer.org/treatment/treatmentsandsideeffects/treatmenttypes/immunotherapy/immunotherapy-monoclonal-antibodies