Migumisiro yeVhitamine C Ngaritaridzire paMarignancy
Paunofunga nezvekudzvinyirira, zvichida pfungwa yako inotendeukira kumapurogiramu, misimboti, miedzo, ukama, kana zvimwe zvinetso izvo munhu angatarisana nazvo muupenyu. Nyika nhasi haigone kuperevedzwa kwezvimwe zvinokonzera kushungurudza.
Uye zvakadaro, haasi munhu wose anopindura nenzira imwechete kune izvo zvinokonzera zvakatipoteredza. Mhedzisiro yemhando yakasiyana-siyana inogona kunge yakawanda, muchidimbu pamusana pekukwanisa kwedu kutsungirira uye kupindura nenzira yakajeka kune zvakatipoteredza.
Ikoko kune imwe yenhamba yekusimudzira, pamwe chete. Sezvo isu tingawana nzvimbo yedu inonyanya kunetseka pane dzimwe nguva, sero rekugara rinogona kuva nemhando dzakasiyana-siyana dzezvinokonzera zvinokonzera-somuenzaniso, molecule inosvibisa mumvura inopoteredza, kana kusakwanisa kuita mukati memaserolekoro emakona.
Apo iwe unofunga nezvemasero emukenza, kunyanya, iwe haufaniri kuvasongedza pakarepo nekunetseka kwekunetseka kwekunetseka. Kanzera dzemasero dzinowanzotsanangurwa nemashoko akadai sekuti 'kusakundikana' uye 'kusingafi' mune kuti vanoita sekubereka uye kupararira pasina mirefu. Icho chinopera, zvisinei, kuti masero emukenza anoshanda pasi pekunetseka kukuru kunyanya, oxyidative stress. Uye vitamini C inogona kuita basa rinokosha apo rinosvika kune mamwe maitiro ekubatsira masero kugadzirisa kudzvinyirira.
Chii Chinonzi Oxidative Stress?
Kunyanya kushungurudzika mupfungwa , mumashoko akajeka, ndiko kusanzwisisika mumasero emunharaunda.
Sezvo pfungwa iyi ichinyanya kuwedzerwa, kusaenzana uku kunogona kuonekwa sehondo isina kukwana pakati pekugadzirwa kwevengi anokuvadza (pasina radicals) uye kukwanisa kwomuviri kurwisa zvinokuvadza zvemuvengi uyu (kuburikidza ne antioxidants).
Iwe unogona kunge wakadzidza nezvemahara radicals mumakemikari: zvakarongeka, zvinorondedzerwa seasuneded molecules izvo zvinowanzoshanda zvikuru uye hupenyu huri pfupi, nemasikironi asina simba.
Semuenzaniso, okisijeni mumakemikari yose mumuviri dzimwe nguva yakakamurwa kuva maatomu asina kukwana e oksijeni, imwe neimwe ine magetsi asingashandeki.
Masikironi anoda kuve ari vaviri, naizvozvo aya maatomu asina kukwana, ayo zvino anonzi radicals akasununguka, atsvaga mamwe magetsi ayo ari chikamu chemuviri, zvinenge sezvikara, kuwirirana ne electron imwe yemamwe molecule mumuviri. Izvi zvinokonzera kushungurudzika, saka, uye zvinokonzera kukanganisa kwemasero, membrane, mapuroteni uye DNA.
Saka, nei kenza yemasero inowanzoshanda pasi pepamusoro wehutano hwekushushikana? Zvakanaka, kazhinji masero aya ane huwandu hwemasimba ehurukuro pamusana pekutanga, kutanga ne, vasati vatova nekenza. Zvadaro, sezvo sero rinotora matanho anowedzera pakuva nekenza, zvinhu zvinowanzochinja mumagariro ekuti kero iyo inoshandisa sei metabolism, iyo inogona kuita kuti kunyange yakakwirira mashandisirwo emhando dzakasununguka.
Kazhinji, kune muganhu pakati pekusununguka kwekushambadzira nekugadzirisa. Kune maviri maviri akasiyana-siyana "mauto," neboka rimwe rinobudisa radicals rusina rusununguko se-superoxide anion (O2-), hydrogen peroxide (H2O2), hydroxyl radicals (OH-), nezvimwewo, uye rimwe boka rinopa antioxidant defense mechanisms [superoxide dismutase ( SOD), catalase (CAT), glutathione peroxidase (GPx), nezvimwewo].
Kana muvengi wekusununguka akasununguka asina kunyatsoratidzwa uye / kana kubviswa, chigumisiro chacho chingava chekuvadzwa kwemasero, nekurasikirwa kwebasa uye kutendeseka kwemuviri wechipinda, pamwe neDNA kukanganisa, kukurudzira kunogona kukuvadza kuchinja mazai uye kusagadziriswa kwesero kwekukura. Iyi yekupedzisira inonzi inozivikanwa sehutachiona husina kusimba, uye inokwanisa kuwedzera mafuta kumoto sezvinoreva rwendo rwenzira yakaipa.
Rusununguko rusununguko uye hutsika hwehupidhi hunobatanidzwawo nehuwandu hwezvirwere zvevanhu kunze kwekenza, kusanganisira chirwere chemoyo, chirwere cheAlzheimer, chirwere chePalinson, nezvimwewo. Panewo hutano hwekukwegura, nekunowedzera zvishoma kwekusununguka-kusagadzikana kwekukuvara.
Zvinhu zvinogadzira radicals pasina zvinogona kuwanikwa munzvimbo yedu, kusanganisira zvokudya zvatinodya, asi zvinowanzoitika mumitumbi yedu sezvinhu zvakasikwa zvemasabelism.
Ndezvipi Zvimwe Zvimwe Zvingaita Mavitamini C Kudzivirira Kurwisa?
Vitamin C yave ichiedzwa mune zvidzidzo zvakasiyana-siyana zvekurapa nekudzivirira kenza; zvisinei, zvigumisiro hazviiti nguva dzose pikicha yakajeka. Mhinduro kumubvunzo webasa re vitamin C mukudzivirira kenza uye kurapwa kunogona kuvimba nehuwandu hwemhuka-uye muzana we vitamini C, pakati pezvimwe zvinhu.
Pazvishoma, vitamini C ine basa re antioxidant, kudzivirira huni. Antioxidant foods, yakazara mu ascorbic acid (vitamini C), carotenoids (vitamini A) uye tocopherol (vitamin E), selenium, uye flavonoids, zvinorumbidzwa nekuda kwechiito chavo chinopesana chekudzivirira kusvibiswa uye kushandiswa kwemhando yakasununguka.
Zvisinei, huwandu hwakawanda hwe vitamine C hunogona kuwedzera kugadzirwa kweAATP (yakagadzirwa nemitochondria) inokonzera programmed cell sekufa mune tumor cell cell experiments, kuburikidza nepro-oxidant mechanism.
Zvidzidzo zvinoratidzira chirwere-chinotarisana nekupikisa kenza basa rinosanganisira zvirongwa zvakasiyana-siyana zvemasero zvinosanganisira programmed cell sekufa, kushandiswa kwemasero kwema cell, uye kuisa masero, nekuwedzera kenza masero kufa mubazi rekuedza kuongororwa kwekenza masero ne mitoxantrone (chemotherapy drug) pamwe chete ne vitamin C .
Ichave Ichava Nebasa rePamusoro-dose Vitamin C muAukemia?
Kusvika ikozvino, zvimwe zvidzidzo zvakaratidza chiitiko chinopesana nemhando dzakasiyana-siyana dzekenza, asi zvimwe zvidzidzo zvakaratidza kuti vitamini C inogona kuita chemotherapi isingabatsiri.
Mhinduro mhomanana kumubvunzo wepamusoro ndewokuti "pamwe," uye zvakare, "inogona kuvimba nehuukemukari." Zvingave zvakakosha kutarisa vitamini C kubva pane dzakasiyana-siyana zvisati zvaita sarudzo pamusoro pemashandisiro ayo mune chero kenza ipi, asi vamwe Kutanga kuwanikwa kubva ku laboratory-based studies ye hematologic malignancies inokurudzira.
Chidzidzo che 2017 pamusoro pemigumisiro ye vitamin C pamasero eukemia yakabudiswa mumagazini "Cell." Mukutaura kwavo, vanyori vakaona kuti uchapupu hwe vitamini C sehutano hwakanaka hwekenza hwakaramba huchikakavhiringidza kusvikira zvino.
Vitamini C Mungaita Maitiro Enzymes Akakosha muAukemia
Kunyanya, boka iri revatsvakurudzi rakadzidza kuchinja kwemajeni mune imwe enzyme inonzi Tet (Ten Eleven Translocation) methylcytosine dioxygenase 2, kana TET2. Vakawana kushamwaridzana kunobatsira ne vitamini C uye iyi enzyme-kushamwaridzana kwakaratidzika kuvandudza kushanda kwemamwe kurapwa kwekenza. Ichi chaiva chidzidzo chemhuka, saka zvinorehwa nevanhu hazvisati zvazivikanwa, asi zvigumisiro zvakashusha.
Mumuviri, masero matsva eropa anomuka kubva pamasero akazvimirira mumusepa wemafuta anonzi hematopoietic stem cells . Zvidzidzo zvekare zvisati zvave zvaratidza kuti tet2 enzyme inogona kuita kuti masero aya emakurira akure kuva masero akachena, akakura, masero eropa-masero anoguma afa kufanana kune chero imwe sero inowanikwa. Kusiyana neizvi, muhutachiona, masero emasero haana kukura zvakakodzera, asi pane kuzvinyora ivo pachavo, kuwedzera muma clones anokuvadza emukopikisi emasero emasero.
Izvozvo zvinokonzerwa nehutachiona hwehutachiona hunokonzerwa kushandiswa kwemasero ndiko kudzivirira muviri kuti urege kubudisa zvakakwana masero eropa ane utano (semuenzaniso, neutrophils, lymphocytes) kuti masimba edu ezvirwere anokwanisa kurwisa zvirwere; kugovera kuderedzwa kwemasero matsvuku eropa kunogona kutungamirira kuanemia, zvakare. Nokudaro, kukanganisa kuhutachiona uye zvinhu zvakadai sekushaya simba kana kushaya simba kubva kune anemia zvinowanzowanzova pakati pezviratidzo uye zviratidzo zveukemia.
Zvakanaka, zvinowanzoitika kuti mune dzimwe mamiriro ekurwara kweukwepa, kwakave nekushanduka kwemazwi, kana kushanduka, izvo zvinogadzira shanduro ye enzyme TET2 iyo isingashande zvakanaka. Nokudaro, chidzidzo che 2017 chakaongorora nzira iyo iyo enzyme, TET2, inogona kukurudzirwa kuita basa rayo, uye kunyanya, kana kana kwete vitamini C inogona kushandiswa mukuedza uku kudzorera utano hwakanaka hwemasero eropa.
Vitamini C TET2 Chidzidzo Chekudzidza
Vatsvakurudzi vedzinza dzakagadzirwa nemagetsi kuti vasaita enzyme TET2, uye vakaona kuti apo TET2 yakavharwa, masero emadziro akatanga kutadza kushanda, uye pavakashandura girasi zvakare, izvi zvakavhiringidzika zvakashandurwa.
Muhosha yehuukemia nedzimwe zvirwere zveropa zvingave zvakakanganiswa nekushanduka kwemajini zvinokonzera teremiyo yeTET2, imwe chete yemakopi maviri eTET2 gene inoshandurwa. Saka vatsvakurudzi vakatarisa kana vitamini C inogona kukwanisa kuitisa iko yakaipa, yakashandurwa, kana kuti yakashandurwa kopi yejeni nekuwedzera basa rekopi iro richiri kushanda kazhinji. Vakawana kuti ne vitamin C, pane zvakasimudzirwa kumagadzirirwo emagetsi akadzorera TET2 basa.
PARP-inhibitors yakadai seorlapari imishonga inodzidziswa kuti inogona kushandiswa mumhando dzakasiyana-siyana dzekenza yeropa uye leukemia. Muchidzidzo ichi, vatsvakurudzi vakabatanidza vitamini C ne PARP inhibitors mumhuka yavo yemuenzaniso kuti vadzidze kubatana. Vakaona kubatana kwakashanda zviri nani, zvichiita kuti zvive zvakanyanya kuoma kumarara emarara ekudzivirira kuzvidzivirira.
Zvakadini Nevhitamini C muLymphoma?
Sezvakawanikwa nezvakawanikwa muroukemia, kutsvakurudza ikozvino mu-pre-clinical stage, zvinoreva kuti izvo zvatinoziva zvinobva kune kuongororwa kwemasero nemhuka mu laboratories, asi kwete vanhu vari mumakiriniki ekuedzwa.
Kunyange zvakadaro, pane, zvichibva pane izvi zvisati zvaitika, zvikonzero zvekutenda kuti zviwanikwa zvakabatana neTET2 uye vitamini C zvinogona kushandiswa kune zvimwe zviitiko zve lymphoma .
Mu lymphoma, TET2 mutations inowanika kazhinji muT-cell lymphomas. Mune imwe lymphoma subtype, angioimmunoblastic T-cell lymphoma , TET2 inogona kuchinjwa mune vazhinji vanoita 76 muzana yevarwere. ITET2 mutation rate inowedzerawo 38 muzana yevarwere vane chirwere chetachiona T-cell lymphoma-kwete zvakatsanangurwa, maererano neongororo yakaitwa na Lemonnier pamwe nevamwe, uye 13 muzana mukupararira kukuru kweB-cell lymphoma .
Shoko Rinobva
Kunyange zvazvo masayendisiti akabudisa tsanangudzo inotaura nezvevhitamini C uye inogona kuita basa mukudzivirira uye kurapwa kwemamwe makondombera, zvakakosha kuva nemwero mukudya mavitamini aya. Zvakawanda zvechinhu chakanaka hachisi chaicho chiri chinhu chakanaka. Uye, nguva dzose inonakidza kutarisa chiremba wako paunotanga humwe humwe huwandu huripo hunogona kukanganisa kurapa kwako.
Hapana humwe uchapupu huripo hunoratidza kuti kuwedzera kwe vitamini C iwe pachako, kupfuura izvo zvinokurudzirwa, kuchazadzivirira kana kuti zvimwe zvinobatsira mukurwara neukemia kana lymphoma, uye kuzviona kwakadaro kunogona kukonzera kukuvara mune dzimwe nguva.
Mune zvidzidzo zvekare, zvakaratidzwa kuti varwere vane hematologic malignancies vangave vasina kukwana mu vitamin C. Saka, kugadzirisa chero huripo huripo hunoita mavitamini C hunogona kuva nzvimbo yakanakisisa yokutanga.
> Sources:
> Cimmino L, Dolgalev I, Wang Y, et al. Kudzorerwa kweTET2 basa kunodzivirira kuzvidzora kuzvitsvaga uye kuwedzerwa kweukwemia. Cell . 2017 Aug 16. pii: S0092-8674 (17) 30868-1. doi: 10.1016 / j.cell.2017.07.032. [Epub mberi kwekudhinda].
> Lemonnier F, Crown L, Parrens M, et al. Zvichidzokorora TET2 kuchinja kwemuviri kune imwe nzvimbo T-cell lymphomas inobatanidza neTFH-kufanana nezviratidzo uye zvirwere zvinorwara zvinorwara. Ropa. 2012; 120: 1466-1469.
> Mikirova N, Casciari J, Rogers A, et al. Migumisiro yepamusoro-dose inopa vitamini C inoputira muchengeti varwere. J Kushandura Med . 2012; 10: 189.
> Shenoy N, Bhagat T, Nieves E, et al. Kukwidziridzwa kweTET basa ne ascorbic acid inobatsira epigenetic modulation ye lymphoma masero. Ropa reKenza J. 2017; 7 (7): e587-. doi: 10.1038 / bcj.2017.65.