Allergy ku Prilosec, Prevacid, Nexium, Aciphex uye Protonix
Proton Pump Inhibitors (PPIs) inowanzoshandiswa mishonga yekurapa gastroesophageal reflux chirwere (GERD) , chirwere chechirwere chechirwere , pamwe chete nekurapa kwezvirwere. PPIs inobata kuvhiringidza mapurusi emudumbu mudumbu, zvichiita kuderedza kubudisa asidi, uye inobudirira pakurapa zvakasiyana-siyana zvakasiyana-siyana-zvine chokuita nehutachiona hwezvirwere.
Kune nhamba yeproton pump inhibitors iripo pamusika, kusanganisira omeprazole (Prilosec), esomeprazole (Nexium), pantoprazole (Protonix), rabeprazole (Aciphex) uye lansoprazole (Prevacid). Kazhinji, maPPIs ane mishonga yakachengeteka ine zvikamu zvishoma zvemigumisiro. Izvi zvichida chikonzero chokuti omeprazole uye lansoprazole zvinowanikwa pane-the-counter / pasina mishonga (sekuda kwezuva iri nyaya iri kunyorwa, esomeprazole, pantoprazole, uye rabeprazole zvinowanikwa chete nemishonga).
Kuongororwa kweAllergy kune Proton Pump Inhibitors
Allergic reactions to proton pump inhibitors haisi kunyanya kufanana asi inoitika. Zvakawanda zvezviitiko izvi zvinosanganisira urticaria , asthma, uye kunyange anaphylaxis . Zvinowanzooma kuziva kuti PPI inokonzerwa nehutano husingaiti sezvo dzimwe mishonga, kusanganisira NSAIDs nemishonga inorwisa mabhakitiriya yakadai sepenicillin , inowanzopiwa pamwe chete nePPIs kuti ibatsire kudzivirira zvironda zvemudumbu kana kuti kubata helicobacter pylori zvirwere.
Tsvakurudzo dzakawanda dzakasiyana dzakaitwa kune vanhu vakambonzwa kugadziriswa kwegwara semugumisiro wekutora proton pump inhibitors. Kuchengetedzwa kweganda , kusanganisira zvose nzira dzakapetwa uye intradermal, zvakaitwa kuburikidza nekushandisa maPIs (pamwe nemimwe mishonga iyo munhu wacho ari kutora) iyo ingangodaro yakakonzera kugadzirisa kwemaitiro.
Izvi zviyero zveganda zvakaratidza kuti zvinobatsira pakutsanangura chikonzero chekugadzirisa kwemaitiro, kunyanya apo PPI ndiyo yaiva chikonzero. Matambudziko omumuromo anoshandisa mutadzi PPI akaita kuti zviratidzo zvehutachiona zviitike apo chirwere cheganda chaive chakanaka. Zvisinei, vanhu avo vakanga vasina kuongororwa kweganda vaisakwanise kuregerera PPI mubvunzo munguva yehurukuro yemuromo.
Cross-Reactivity Pakati peProton Pump Inhibitors
Zvishanu zvakasiyana-siyana zveproton pump inhibitors hazviwiri pamwe chete nemakemikari akaumbwa, anoratidza kuti kana munhu aine allergi kune imwe PPI, imwe kana kuti mamwe emamwe mapiritsi angabvumirwa. Zvidzidzo zvakaitwa pamuchinjikwa-reactivity zveproton pump inhibitors zvakawana kuti vanhu vanokonzera omeprazole vanowanzokanganisika kune pantoprazole (uyewo zvinyorwa), uye vanhu vanoraramira kune lansoprazole vanowanzotarisana ne rabeprazole (uye zvimwewo). Uyu muchinjikwa-reactivity unokonzerwa nezvikwangwani zvakafanana pakati pevamwe maPIs; kushayikwa kwepakati-reactivity pakati pevamwe maPIs kunogona kubvumira munhu ane utano kune mumwe munhu wePPI kuti ashivirire imwe PPI. Semuenzaniso, vanhu vanokonzera omeprazole kana pantoprazole vanowanzogona kutora lansoprazole kana rabeprazole, uye izvo zvinokonzera lansoprazole kana rabeprazole zvinowanzogona kutora omeprazole kana pantoprazole.
Kune vanhu vakambosangana nemagetsi ezvo nekuda kwekutora imwe proton pump inhibitor, kuongororwa kweganda kunogona kubatsira mukusimbisa kuongororwa. Kana kuongororwa kweganda kune avo vanokanganisa PPI kune chakanaka, ipapo kuongororwa kweganda kumunhu asina kukwira-kubata PPI kunogona kuitwa mukuedza kuwana PPI iyo munhu anokwanisa kuzvitsungirira. Zvisinei, dambudziko remuromo, rinoitwa pasi pekutarisirwa kwehutano, rinofanira kuitwa neusina-cross-reacting PPI (ine chirwere chisina kunaka cheganda) kuve nechokwadi chokuti yakachengetedzwa zvakanaka.
Dzidza zvakawanda pamusoro pekuongororwa uye kurapwa kwezvinodhaka zvirwere .
> Sources:
> Bonadonna P, et al. Hypersensitivity kwaProteton Pump Inhibitor: Kuongorora Kuona Kweganda Kuedzwa Kunofananidzwa Nekutsvaga Mumuviriro. J Allergy Clin Immunol. 2012; 130 (2): 547-9.
> Chang YS. Hypersensitivity Reactions kuProton Pump Inhibitors. Curr Opin Allergy Clin Immunol. 2012; 12: 348-53.
> Lobera T, et al. Nhamba Nhatu dzeOmeprazole Allergy. Cross-Reactivity Pakati peProton Pump Inhibitors. J Investig Allergol Clin Immunol. 2009; 19: 57-60.
> Perez Pimiento AJ, et al. Hypersensitivity kuna Lansoprazole uye Rabeprazole nekutsungirira kune zvimwe Proton Pump Inhibitors. 2006; 117 (3): 707-8.