Taxotere yeCrostate Cancer - Inoshanda Rini uye Zvakanaka Zvakadini?
Iko uye sei Taxotere (docetaxel) inoshanda sei pakushandisa kenza yeprostate ?
Taxotere (Docetaxel) Inoshanda Sei?
Taxotere (docetaxel) inoshanda zvakafanana kune mishonga yemakemikrasi akawanda kuburikidza nekuvhiringidza masero ekuparadzanisa (anonzi mitosis). Sezvo kenza yemasero ndeimwe yemasero ekuparadzanisa zvakanyanya mumuviri, aya masero anonyanya kuonekwa nechisarudzo che Taxotere uye, nokudaro, anofa pamatunhu akakwirira kana mushonga wacho uri kutarisirwa.
Mukuwedzera kune kenza yeprostate, Taxotere inogona kushandiswa kune vanhu vane mamwe marudzi emukenza wemapapu, kenza yemvere, kana kenza yemuvha.
Nhoroondo - Taxotere yeHormone-Resistant Advanced Prostate Cancer
Taxotere yakaunzwa muhutano hwekenza yekenza yeprostate mushure mekunge kubudiswa kwakabudiswa muNew England Journal of Medicine muna 2004 iyo yakaratidza kuti Taxotere pamwe chete nesteroid prednisone yakaguma nokuvandudza kupona kana ichienzaniswa neyero-inodhaka yemishonga yekenza yepamusoro ye prostate , mitoxantrone. Nyaya yeNew England Journal yakaratidzawo kuti varume ivavo vaibata neTareotere vaiva nehuwandu hwakanaka hwehupenyu uye hunovandudzwa nekurwadziwa. Panguva iyoyo, Taxotere yaifungidzirwa kuva kurapa kwekusarudza kwekenza yepamusoro yeprostate muvarume vane kenza yeprotate yakanga yapararira kunze kweprostate uye yakanga yava kusagadzikana nehutoni remapirisa .
Taxotere ichiri kuonekwa sarudzo yakanaka (pamwe nemamwe mishonga iri kuongororwa) kuti ishandiswe mune varume vane kenza yemastrostate iyo yava kusagadzikana nehommone therapy (androgen suppression therapy.)
Ikozvino - Taxotere yeArmorine-Early Sensitive Metastatic Prostate Cancer
Zvidzidzo zvikuru zvakadai sechirongwa che CHAARTED pakati pevamwe zvakashandura nzira yekutanga kwemaitiro emakemhoni eprotate ane hutano hwevarume vakawanda. Aya kanzura inogona kunge yakagadziriswa panguva yekuongororwa kana kuti yakava metastatic mushure mekurapwa kwekutanga kwekenza yekenza yepa prostate .
Kunyange zvazvo Taxotere yakanga isati yashandiswa kune varume vane kenza yepamusoro yeprostate avo vakanga vava kusagadzikana nemishonga inonzi hormonal therapy, zvinoita sokuti kushandisa Taxotere kurapwa kare-panguva imwechete iyo kurapwa nehormonal therapy inotangwa - ine zvinobatsira mune zvose zvirikuwedzera-pasina kupona uye zvachose kupona. Zvechokwadi, Taxotere ine migumisiro yemigumisiro yekushushikana chero chero ipi zvayo yemishonga yemakemikari, asi izvi, pamwe nekufambira mberi uchishandisa mamwe mishonga, chiratidzo chinonakidza chekufambira mberi mukurapa kenza yeprostate.
Taxotere yeChechi yepamusoro yeProstate Cancer
I STAMPEDE Trial yakatora varume vane kenza yepamusoro yeprostate yepamunharaunda. Varume vakapiwa Taxotere panguva iyo hormone therapy yakatanga yakatorwa kuva nehuwandu husina zvirwere-pasina uye kurarama kwevanhu vakawanda kune avo vaibatwa ne hormonal therapy chete. A caveat ndeyekuti varume avo vanonyanya kutsvaga kurapwa uku ndevaya vane "high-volume" kenza ye prostate.
Adjuvant Treatment yeHain-Risk Localized Cancer Prostate
Kune varume vane hutachiona hwepamusoro-soro avo vari mungozi yakakura, vachishandisa Taxotere mune imwe nguva yemajairo (an "kana" mamiriro ezvinhu) akawanikidzwa kuderedza zvakanyanya kuitika kwemaitiro ekuresa (kupararira) kwekenza yavo ye prostate.
Varume ava vakabatwa neTareotere pamwe nehomoni inonzi hormone and therapy , panzvimbo pane hormonal therapy uye therapy ye radiation chete. Zvechokwadi, Taxotere ine zvimwe zvinosangana nemigumisiro yakaipa iyo inoda kuonekwa.
Chii Chiri Nhengo Dzose
Sezvo nezvose chemotherapy zvinodhaka, pane mararamiro akasiyana-siyana anogona kuitika kana achitora Taxotere. Iwe unogona kunge uchiziva zvimwe zveizvi sezvazvinowanzobatwa nemhando dzakawanda dzekemotherapy. Izvi zvinotevera migumisiro inowanikwa kune chikamu chetatu chevanhu vanoshandisa Taxotere:
- Neutropenia - A low white blood cell count iyo inogona kutarisa kuhutachiona.
- Anemia - A low red cell cell count izvo zvinogona kukonzera kuneta pakati pezvimwe zviratidzo.
- Kuora bvudzi
- Fluid retention
- Diarrhea
- Nausea - Ichi chiratidzo chinowanzonyatsorongedzwa pamwe chete nemishonga inoshandiswa pakurwisa
- A rash
- Makuvara emuromo
- Fingernail changes
- Anoriginal reaction - Izvi zvakajairika, uye mishonga yekudzivirira zvirwere zvinokonzera zvirwere zvinowanzopiwa pamwe chete nekukanganiswa.
Sources:
Fizazi, K., Jenkins, C., uye I. Tannock. Ko docetaxel inofanira kuva yakakwana yekutarisira varwere vane kenza ye prostatic-sensitive sensitive prostate? Pro uye zvinopesana. Annals of Oncology . 2015. 26 (8): 160-7.
Goodman, A. Docetaxel Akabatanidzwa neHormone Therapy Inowedzera kupona muZvirevo zvepamusoro zveCrostate Cancer. Iko Post ASCO . http://www.ascopost.com/issues/may-25,-2015/docetaxel-combined-with-hormone-therapy-extends-survival-in-advanced-prostate-cancer.aspx.
James, N., Sydes, M., Clarke, N. uye al. Kuwedzerwa kwe docetaxel, zoledronic acid, kana zvose kumutambo wekutanga-hormone therapy mune kenza yeprostate (STAMPEDE): kupona kunoguma kubva kune chinogadziriswa, chinowedzera, chizhinji, chikwata chisingatariswi chekuedzwa. Lancet . 2015 Dec 21. (Epub mberi kwekudhinda).
Martel CL, Gumerlock PH, Meyers FJ, et al. Nhasi mazano ari kutungamirirwa kwekenza yemakemikari inokonzera prostate. Cancer Bata Rev. 2003; 29: 171-187.
National Cancer Institute. NIH-inobhadhara mari inoongorora inowedzera kupona muvarume vane kenza yemastrostate iyo inogamuchira chemotherapy painotanga hormone therapy. http://www.cancer.gov/news-events/press-releases/2013/E3805.
Tannock IF, naWe Wit, Berry WR, et al. Docetaxel plus prednisone kana mitoxantrone uye prednisone yekenza yepamusoro ye prostate. N. Engl. J. Med. 351 (15): 1502-12.