Maintenance Therapy yeLung Cancer

by Lynne Eldridge, MD; Yakadzokororwa na Grant Hughes, MD

Ndezvipi zvinangwa zveMaintenance Therapy for Lung Cancer?

Iwe unogona kunge wakanzwa nezvevamwe shamwari uye vadiwa avo vave vachirapa kurapa kwekenza. Asi kugadzirisa kurapwa kwemapapu emapapu kwakangotariswa panguva ichangopfuura. Inguva ipi yekurapa kwekuchengetedza inoshandiswa kumushana wemapapu uye ndezvipi zvinangwa zvekurapa uku?

Chii Chinonzi Maintenance Therapy?

Usati watanga kutaura pamusoro pemishonga inoshandiswa, inobatsira kutsanangura chaizvoizvo chirongwa chekuchengetedza chiri.

Chirongwa chekuchengetedza chirwere rudzi rwemishonga inoshandiswa nemukenza wemapapu wakakurumbira - kunyanya, mberi kwechirwere chemukati yemapapu emapapu kuedza kuvandudza kupona, asi kwete "kurapa" kenza. Izvi zvinopesana nezvimwe zvirwere zvezvikamu zvekare zvemukenza wemapapu zvinogona kupiwa nehupfungwa mupfungwa.

Inogonawo kushandiswa pane dzimwe nguva kune vanhu vane kenza yemukomana kadiki (ona pasi apa.)

Imwe tsanangudzo yakajeka yekuchengetedza chirwere ichi chinoramba chichishanda kurapwa kwechirwere chisina kufambira mberi (chakaipa) pashure pokutanga chemotherapy - kusvikira pane zviratidzo zvekuti kenza yafambira mberi (yakaipa.) Nemamwe mazwi, iyo kurapa inopiwa chinangwa chekuchengetedza tumarara asiri kukura nokukurumidza mukutarisa, kwete kurapwa kwakagadzirirwa kurambidza kana kuporesa tsvina.

Zvinangwa zveMaintenance Therapy

Nekupi kurapwa kwekenza iwe unofunga, zvakakosha kufunga pamusoro pezvinangwa zverapi.

Nezvo izvi mupfungwa, zviri nyore kwazvo kuongorora njodzi dzekurapa kunopesana nezvinobatsira. Izvi zvinangwa zvina zvinotevera ndezvi:

Preventive
Curative
Kurwara kwehutano
Palliative

Maintenance therapy inoshandiswa pakurapa zvirwere. Hazvirevi kurapa, asi "zvinowedzera" kupfuura kupora kwakanyanya pakuti zvakagadzirirwa kuita zvinopfuura kungobatsira zviratidzo chete - chinangwa chayo ndechokuwedzera kupona uye hupenyu hwehupenyu munguva yekupona.

Rinoshandiswa Rini?

Kufananidza chirongwa chekuchengetedza kwemapapu emapapu zvinowedzera, ndiko kushandiswa kwemishonga mushure mekunge mumwe munhu aporerwa nemakakatanwa mana e "kutanga-line" chemotherapy yepamusoro (danho rechipiri IIIA nechitambo IV) kenza yemapapu kana kenza haina kufamba panguva iyi yekutanga -line kurapa. Sezvo munguva yakapfuura, vanhu vakanga vasati varapwa zvakare panguva ino (uye pane izvi zvakateverwa nenguva ye " kurindira kumirira " - kureva, kuongorora zviratidzo uye kuongorora radhiology kuti vaone kana kenza ichakura), chirongwa chekuchengetedza chakagadzirwa kubatsira nezviratidzo zvekenza, uye, netariro kunatsiridza kuponesa nguva kupfuura izvo zvakapiwa nemishonga yekutanga chemotherapy.

Kune zvakawanda zvinokakavadzana zvakapoteredza kushandiswa kwemishonga yekugadzirisa. Sezvakaita chero kurapwa kupi zvayo, migumisiro yemigumisiro yehupano inofanira kuyerwa nemupiro unobatsira. Uye-muhupfumi hwedu huripo - mari inofanirwawo kufunga. Mishonga yakagadzirirwa "kugadzirisa" inogona kudhura. Zvimwe zvidzidzo zvinoratidzira huri huri nani huri nani hupenyu huripo (imwe nyaya yemazuva kusvika masvondo akawanda), uye mhuri dzinowanzosiyiwa nekuyera kuwedzera kunononoka mukurarama pamwe nemutoro wemari wekurapa.

Ndeapi Mishonga Inoshandiswa?

Parizvino, kune mishonga miviri yakagamuchirwa neDDA yekurapwa kwehutano hwekenza yemapapu yakapfuura.

Mimwe miviri mishonga (uye kusanganiswa kwemishonga) iri kuongororwa mumakiriniki ekuedzwa . Mishonga inobvumirwa inosanganisira:

Alimta (pemetrexed) - Muna 2009, FDA yakabvumira kushandiswa kweAlimta pakurapwa kwekenza yemapapu.
Tarceva (erlotinib) - The FDA yakagamuchira Tarceva kuti ishandiswe sekurapa kwekuchengetedza kenza yemapapu muna 2010.

Ndiani Anobatsira Zvikuru?

Sezvo nemishonga yakawanda yemukenza wemapapu, pane vamwe vanhu vanopindura zvakanyanya kupfuura vamwe kune kurapa.

Zvidzidzo naAlimta zvakaratidza kuti zvinoratidzika zvakakosha kune vanhu vane mapapu adenocarcinoma uye mukana mukuru wekenza yemapapu. Inoratidzikawo kuti inoshanda zvikuru kune vanhu vane EGFR mutation .

Zvidzidzo neTarceva zvinoratidzawo kuponesa kwakapfurikidza zvikuru kune vanhu vane vasero vashoma vemaikenza emapapu asingasviki chepamente yemapapu emapapu. Inoratidzikawo kuti inobatsira vanhu vane EGFR mutation kune imwe huru kune avo vasina mutsika. Kubudirira kukuru kwekuchengetedzwa kwechiremba neTarceva kwakawanikwa nekuda kwekusambo-kusvuta vakadzi vakange vari muhutano hwakanaka pane imwe nguva panguva yekurapa kwavo.

Migumisiro Yechiri uye Matambudziko

Maintenance Therapy for Small Cell Chirwere Chirwere Chikanyanya

Kunyange zvazvo chirongwa chekugadzirisa chinoshandiswa zvikuru pamusana pediki masero emakamu emapapu, miviri yekuchipatara yakangodaro inoratidza kuti panogona kuva nechinzvimbo muzamu rakazara chekenza yemapapu emapapu pasi payo, pamwe nekutarisa kuhupenyu huripo hunoonekwa pakati pevanhu vanobatwa nekuchengetedza sunitinib plus prophylactic cranial irradiation.

Kutsigira uye Kukunda

Zvakataurwa kuti chimwe che "madhara" echirongwa chekuchengetedza ndechekuti vanhu havaoni pfungwa yekupedzisa kurapwa. Mune mamwe mazwi, havanzwi se "vanopona." Zvinogona kubatsira kuchengetedza mupfungwa kuti hutachiona hwehutachiona hwepabonde hunofungidzirwa sehutano hwekuchengetedza zvakare, uye huwandu hwevanhu vakave nekenza yebonde vachiri kutora hormonal therapy, kana tamoxifen kana kuti aromatase inhibitor pavanopedza kenza . Inogonawo kubatsira kukuyeuchidza tose chetsanangudzo yekuparara kwekenza: mumwe munhu anopona nekenza kubva panguva yaanoonekwa kuti ane chirwere, uye kwehupenyu hwavo hwose.

Zvichida kuti chirwere chekenza yemapapu chekumapapu chichawedzera mukati mavo maviri nhamba yevanhu vachishandisa kurapwa uku uye mukukosha kwayo. Pfungwa iyi ndeyokuti isu tatanga kutora chirwere chemapapu zvinowedzera sechirwere chisingaperi . Hatigoni kurapa vanhu vazhinji, asi chirwere chinogona kutarisira kutarisirwa kwenguva yakareba.

_Sources:

_{Ahn, M. et al.} _{Kubudirira kwekuchengetedza Pharmacotherapies yeChina Isina-Small Cell Lung Cancer.} _{Clinical Medical Insights.} _{Oncology .} _{2012. 6: 253-262.}

_{American Society of Clinical Oncology.} _Cancer.Net. _{Kunzwisisa Maintenance Therapy.} _{Yashandurwa 08/15.} _{http://www.cancer.net/navigating-cancer-care/how-cancer-treated/understanding-maintenance-therapy}

_{Banz, K. et al.} _{Kuenzaniswa kwemari yekurapa mari yegorosi 3/4 zviitiko zvakashata zvinosangana ne erlotinib kana pemetrexed maintenance therapy kune varwere vane chekuita vasati vaduku-kemukirini yemapapu emapapu (NSCLC) muGermany, France, Italy, neSpain.} _{Lung Cancer .} _{2011 May 16. (Epub mberi kwekudhinda).}

_{Brugger, W. et al.} _{Zvinotarisirwa kuMorecular Marker Kuongorora kweEGFR neKRAS Kubva muRandomized, Placebo-Controlled Study ye Erlotinib Maintenance Therapy muZvinyorwa Zvisingasvikidiki-Muchengetedzo Wemagetsi.} _{Nyaya yeCliniki Oncology .} _{2011 Oct 3. (Epub mberi kwekudhinda).}

_{Cappuzzo, F. et al.} _{Erlotinib semishonga yekuchengetedza mune yakashata isina-duku-sepenomenza yemukenza yemapapu: mazamu akawanda, randomized, placebo-akadzingwa chikamu chechitatu.} _{Lancet Oncology .} _{2010. 11 (6): 521-9.}

_{Chen, X., Liu, Y., Roe, O. uye al.} _{Gefitinib kana erlotinib sechirwere chekuchengetedza kune varwere vane chikwata chepamusoro chechirwere chemapapu chemapapu chepamusoro: kuongorora kwakarongeka.} _{PLoS One .} _{2013. 8 (3): e5934.}

_{Ciuleanu, T. et al.} _{Maintenance pemetrexed pamwe nekuchengetedza kwakanyanya kunotsigira pamwe ne placebo pamwe nekuchengetedza kwakanakisisa kuchengetedza mutova usina-muduku-masero emumapapu: randomised, double-blind, phase 3 study.} _{Lancet .} _{2009. 374 (9699): 1432-40.}

_{Cohen, M. et al.} _{Chidimbu chekubvumira: erlotinib maintenance therapy of advanced / metastatic non-small cell cancer lung (NSCLC).} _{The Oncologist .} _{2010. 15 (12): 1344-51.}

_{Cohen, M. et al.} _{Chidimbu chekubvumira: pemetrexed maintenance therapy yepamusoro / metastatic isina kufanira, kwete-duku kenza yemukenza yemapapu (NSCLC).} _{The Oncologist .} _{2010. 15 (12): 1352-8.}

_{Coudert, B. et al.} _{Kuponeswa kunobatsira ne erlotinib kugadzirisa therapy kune varwere vane advanced non-small-cell lung lung cancer (NSCLC) maererano nemhinduro kumushonga wekutanga chemotherapy.} _{Annals of Oncology .} _{2011 May 24. (Epub mberi kwekudhinda).}

_{Dickson, R. et al.} _{Erlotinib Monotherapy nokuda kwekuchengetedzwa kwekuchengetedzwa kweMusana-Small Cell Lung Cancer pashure pePlatinum yapfuura-ine Chemotherapy: A NICE Single Technology Kuongorora.} _{Pharmacoeconomics .} _{2011 Oct 3. (Epub mberi kwekudhinda).}

_{Greenhalgh, J. et al.} _{Pemetrexed for the maintenance treatment of a non-small cell cancer lung.} _{Health Health Assessment .} _{2010. 14 (Suppl. 2): 33-9.}

_{Jiang, Y., Liu, L., Shen, L. et al.} _{Traditional Chinese Medicine Treatment as therapy therapy in advanced non-small-cell cell lung cancer: A trial randomised controlled.} _{Mishonga Inobatsira Mukurapa .} _{2016. 24: 55-6.}

_{Han, Y., Wang, H., Xu, W. et al.} _{Chinese herbal medicine sechirongwa chekuchengetedza kwekuvandudza hutano hwehupenyu hwehutachiona husati huri duku hwechirwere chechillung.} _{Mishonga Inobatsira Mukurapa .} _{2016. 24: 81-9.}

_{Hu, X., Pu, K., Feng, X. et al.} _{Basa reGemcitabine uye Pemetrexed seMaintenance Therapy in Advanced NSCLC: Ongororo yakarongeka uye Meta-Kuongorora kweRandomized Controled Trials.} _{PLoS One .} _{2016. 8:11 (3): e0149247.}

_{Karayama, M., Inui, N., Fujisawa, T. et al.} _{Maintenance therapy ne pemetrexed uye bevacizumab maererano ne pemetrexed monotherapy mushure mokunge inductive therapywith carboplatin, pemetrexed, uye bevacizumab kune varwere vane chirwere chisina kukonzerwa nekemukirini chemapapu chepamusoro.} _{European Journal of Cancer .} _{2016 Feb 25. (Epub mberi kwekudhinda).}

_{Klein, R. et al.} _{Mariko-kubudirira kwe pemetrexed sokurapa kwekutanga-line yekurapa kwechirwere chisingaiti chediki chemapapu emapapu.} _{Nyaya yeTraracic Oncology .} _{2010. 5 (8): 1263-72.}

_{Kulkarni, S., Vella, E., Coakley, N. et al.} _{Kushandiswa kweSystemic Treatment Mukuchengetedzwa kwevarwere nevasiri-duku Cell Lung Cancer: Ongororo yeChechi.} _{Nyaya yeTraracic Oncology .} _{2016 Mar 21. (Epub mberi kwekudhinda).}

_{Lu, S., Yu, Y., Chen, Z. et al.} _{Maintenance Therapy Inovandudza Zvibereko Zvokuchengetedzwa Muvarwere Vachiri Kuwedzera Kwete-duku Cell Lung Cancer: A Meta-analysis ye 14 Studies.} _{Lung .} _{193 (5): 805-14.}

_{Muir, V., uye S. Chillon.} _{Erlotinib: sekuchengetedza monotherapy mune zvisiri-duku-kenza yemukenza yemapapu.} _{BioDrugs .} _{2011. 25 (3): 139-46.}

_{Petrelli, F. et al.} _{Erlotinib sechirwere chekuchengetedza kune varwere vane mishonga isiri duku duku yemukenza yemapapu: kuongororwa kwakaitwa zvitatu zvinongororwa mutsva.} _{Anticancer Zvinodhaka .} _{2011. 22 (10): 1010-9.}

_{Pinquie, F., de Chabot, G., Urban, T., uye J. Hureaux.} _{Maintanance Treatment neEroltinib Inotyisa Cardiomyopathy: A Case Report.} _{Oncology .} _{2016. 90 (3): 176-7.}

_{Qi, W. et al.} _{Erlotinib uye pemetrexed sechirongwa chekuchengetedza kwechikwata chisingapfurikidzi chekenza yemapapu emapapu: kuongorora kwakarongeka uye kuenzanirana kusina kukodzera.} _{Research Current Medical and Opinion .} _{2012 Mar 14. (Epub mberi kwekudhinda).}

_{Rodriguez, P., Popa, X., Martinez, O. et al.} _. _{Clinical Research Cancer .} _{2016 Feb 29. (Epub mberi kwekudhinda).}

_{Salama, J., Gu, L., Wang, X. uye al.} _{Kubatana kwakanaka pakati peProphylactic Cranial Irradiation uye Maintenance Sunitinib yeChirwere Chisina Kuwedzera-Chikamu Chidiki Chirwere Chirwere Chirwere Chekupedzisira Pashure Pechipiri Chemotherapy: Kuchengetedzwa Kwechipiri kweCALGB 30504 (ALLIANCE).} _{Nyaya yeTraracic Oncology .} _{2016. 11 (3): 361 = 9.}

_{Schneider, B. Maintenance sunitinib yemukati mutsva muduku wekenza yemapapu: chimiro chitsva, chisarudzo kana danho riri munzira yakarurama?} _. _{Kushandura Kwemafungiro Emaronda Ongororo .} _{2015. 4 (5): 6358.}

_{Mufudzi, F. Maintenance Therapy Inouya Nezera Rokuti Ndisiri Muduku-Chirwere Chemapfupa Anomukomana, asi paIi?} _. _{Nyaya yeCliniki Oncology .} _{2011 Oct 3. (Epub mberi kwekudhinda).}

Chii Chinonzi Maintenance Therapy?

Zvinangwa zveMaintenance Therapy

Rinoshandiswa Rini?

Ndeapi Mishonga Inoshandiswa?

Ndiani Anobatsira Zvikuru?

Migumisiro Yechiri uye Matambudziko

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