Basa rakasiyana-siyana uye rinonakidza iro macrophages rinotora chirwere kukura - kana kuderedza - inotsvakurudzwa yakawanda uye yakakumbidzana nyaya. A macrophage rudzi rwechichena cheropa, iro chikamu chemuviri wako wezvirwere. Simba remuviri revanhu rinotarisirwa kuziva, kuparadza, uye kubvisa zvinhu zvose zvekunze kubva mumuviri. Zvisinei, macrophage inonyangadza uye inotora mabasa akasiyana mukukura nekupararira kwekenza masero.
Chii chinonzi Macrophage?
Macrophages inotanga se monocytes uye inobudiswa mumapfupa ako. Sezvo aya masero machena ari kukura uye achibudiswa muropa rako mumvura vanoenda uye uye vanochengetwa mukati mepleen yako, lymph nodes, tonsils, kana muropa rako. Kana kukanganisa, hutachiona, kana kunyange kukuvadzwa kunokonzera mhinduro, monocytes inobva panzvimbo yavo yepamusoro uye inofamba neropa rekupinda mune dzimwe mishonga uye nhengo mumuviri. Mushure mekusiya ropa, monocytes inokura kuva macrophage .
Macrophage Ive Mabasa Akawanda
Mumufananidzo mukuru wezvinhu, macrophages inogona kuuraya uye kuparadza mabhakitiriya, kuchenesa mabhiriyamu emagetsi uye zvimwe zvinokonzera zvinokonzera, pamwe chete nemasero akafa ane microbes, zvakadai sebhakitiriya kana mavairasi. Mushure mokunge macrophage inopedza masero aya akafa, inotora zvimwe zvinyorwa kubva mumakemikari mukati memusero - chinyorwa chemukati kana iwe uchida-uye uchichipa kune mamwe masero muzvidzivirira zvemuviri.
Nenzira iyi, macrophages "inogona kurira inzwi" kuti muvengi wekune imwe nyika ari mumuviri uye anobatsira mamwe masero ezvirwere zvekuzvidzivirira anoziva kuti muvengi.
Basa muColorectal Cancer
Mukuvapo kwekenza, macrophage ine mabasa akasiyana, zvinoshandiswa izvo zvichiri kuongororwa. Kana vachinge vachifamba neropa mukati memarara , vanova macrophages kana maTAM ane maronda.
Kunyange zvazvo chinangwa chekuita macrophage ndechokuparadza nekubvisa vatorwa vekune imwe nyika - yakadai semasero emukenza anoumba chirwere - takaziva kuti zvinhu zvakasiyana-siyana zvinoshandura macrophages chaiwo kupindura panguva ino.
Kazhinji, kana bundu rako rine nhamba yakakura yeTAMs mukati, inowanzova chiratidzo chisina kunaka chekufananidzira, izvo zvinoreva kuti kenza inogona kunge yakagadziriswa , kana kupararira kune mamwe maviri mumuviri wako. Pamusana pezvikonzero kunze kwehuwandu hwechikamu chino, mamwe macrophages anoramba achiita izvo zvavanoda kuita mukati mechirwere uye anotanga kubatsira rubururu kukura nekupararira. Kutsvakurudza kwakaratidzawo kuti aya maTAM, kusiyana neavo vari kunze kwechirwere, haashoma kuzivisa maitiro ezvirwere zvemuviri wako wekenza, izvo zvinonoka kukusimbisa kubva mumuviri wako wesimba.
Iyi ndiyo iyo basa re macrophage rinowanzofadza. Mune zvidzidzo zvemazuva ano zvekuzvidzivirira kwemuviri kumusana wechirwere, zvinowanikwa kuti maTAM masere anotevedza zvakanyanya mumhando mbiri dzakasiyana dze macrophages: M1 uye M2 marudzi. Apo mhando yeM1 inoramba ichirwisana nemakero emakenza emakero, M2 yakawanikwa kuti inobatsira kukurudzira ronda raro kukura, metastasis, uye regrowth.
Kushandisa Zviratidzo Zvako Zvokudzivirira Kubva: Mazuva Ekupedzisira Maitiro
Kunyangwe izvi zvinonzwika semashoko anonyangadza - masero chaiwo anochengetedza nekuporesa muviri wako uye iye zvino achibatsira kenza kukura - tsvakurudzo iri kutarisa nzira yekugadzirisa macrophages kubva mukugadzirisa pane chimwe chinhu chinokosha mumuviri wekuzvidzivirira.
Kana kutsvakurudza uku kwasvika pakubudirira, mishonga mishonga yemishonga inogona kuumbwa kubatsira kubvisa metastasis, kuchengeta kenza yepamusoro yeharaunda, uko kuri nyore nyore kurapa.
Zvidzidzo zvekudzidza zvakawanda pamusoro pekushandiswa kweTAMs mukodha yepamusoro inoramba iripo. Ongororo yemazuva ano inonyanya kushandiswa pakushandisa mhinduro yekuzvidzivirira mumuviri - kunyanya kuketwa kwezviitiko zvinowanikwa apo kenza inotanga - uye kuti tingamisa sei masimba edu emagunha kubva pakukonzera maitiro ekurwisa mastasisini.
Sources:
Morris, KT, et al. (2015) Anti-G-CSF Kuchengetedza Kunobatsira Kudzivirira Chirwere Chisingagoneki muMouse Colon Cancer kuburikidza nekukurudzira kudzivirira NK Cell, Macrophage, uye T Cell Responses. Oncotarget. Inowanikwa paIndaneti kuburikidza nePublicMed.gov.
Mosser, DM, Edwards, JP (December 2008). Kutsvaga Izvo Full Spectrum yeMacrophage Activation. Zvinyorwa zveChechi Zvekuongorora uye Immunology . 8 (12); 958-969. Inowanikwa paIndaneti kuburikidza nePublicMed.gov.
Zhang, Y., et al. (October 2013). Crosstalk Pakati peConon Cancer Cells uye Macrophages Via Inflammatory Mediators uye CD47 Inokurudzira Tumor Cell Cell. European Journal of Cancer . Inowanikwa paIndaneti munaJuly 12, 2015.
Yakarongwa naJuliet Wilkinson, RN, BSN