Zvidzidzo zvakakomberedza Lupron kana Zvirongwa zvokurapa maererano nekenza yemastrostate yeprostate , kutanga kurapwa pane imwe nguva yapfuura kwakaguma nekuwedzera kwekuwedzera kwehutano hwehutano. Saizvozvowo, zvidzidzo kuongorora kubudirira kwekutanga Taxotere pane imwe nguva yapfuura zvinoratidza chinhu chimwe chete.
Kutanga Taxotere pane imwe Nhanho Yokutanga
Taxotere yave iri kuenda-chemotherapy yepamusoro, kanomutachiona-resistant prostate kanzera kwemakore gumi.
Yakagamuchirwa neRWA muna 2004 mushure mekunge ichiratidzwa kuti iwedzere kupona. Pamberi peRAA kugamuchirwa kweTareotere, chete chete inowanikwa chemotherapeutic agents (Novantrone, Emcyt, uye Velban) yaiva yehuwandu hwemiganhu. Somuenzaniso, Novantrone inogona kuderedza marwadzo nekuvandudza hupenyu hwehupenyu. Kunyange zvakadaro, yakanga isingabatsiri pakupona. Taxotere yaiva FDA yakagamuchirwa pashure pemiti miviri mikuru yakasarudzwa yakaratidza kushandiswa kwekuchengetedza, zvisinei, kuwanda kwekusimuka kwehupenyu kwaive kuduku, kungoenderana nemwedzi mishoma.
Kwemakore, nyanzvi dzave dzichitsvaga pamusoro penguva yakakodzera yekushandisa Taxotere. Inofanira kutanga kana mushure mokurwisana naLupron kunotanga here kana kuti zvingava zvakakosha kutanga kusati kwatanga kushandiswa kwehomoni? Sezvo zvidzidzo zvepakutanga zvichiendesa kuDAA-kugamuchira kweTareotere yakaratidza kubudirira kwayo kune varume vakange vatotadza kusagadzikana, mutemo mukuru wakagamuchirwa navanachiremba wakanga uchidzivisa Taxotere kusvikira Lupron isingaiti.
Vanachiremba vaizofunga sezvinotevera: "Sezvo Taxotere ine migumisiro yakasiyana-siyana, uyewo, sezvo pasina uchapupu hwokuti kunyanya kurapwa kwakanyatsobudirira, isu tichatongotanga kutanga Taxotere mushure mokunge Lupron inogumira kushanda."
Zvinonyatsozivikanwa kuti vazhinji varume vane kenza yemastrostate pakupedzisira vanoita kuti hurumende isaramba.
Saka, sezvo kurapwa kwepakutanga kunowanzobudirira, zvingava zvine musoro kufunga nezvekurwisa chirwere pamberi pemasero asingagoni kushandiswa achiwedzera mberi uye kupinda mumakironi asingagoneki. Muna 2014 na2015 migumisiro yemakirini maviri emakirini ekuongorora izvi zvakabudiswa.
Migumisiro yeZvakadzidza Zvidzidzo
Chidzidzo chekutanga, CHAARTED (Chemo-hormonal Therapy versus Androgen Ablation Randomised Trial for Extensive Disease in Prostate Cancer), yakabudiswa muna 2014 musangano wegore negore weAmerican Society of Clinical Oncology (ASCO) uye yakabudiswa muNew England Journal of Medicine muna 2015 Izvi zvakaratidza kuti kune varume vane kenza yeHenmone-yakangobva kuonekwa, mune varwere vakanga vatotanga metastases, kuwedzerwa kwemwedzi mina yeTatotere yakatanga pamwe chete naLupron zvakanyanya kuwedzera kupona kufanana nevarume vakatanga Lupron voga ndokutanga Taxotere apo iyo Lupron yakamira kushanda. Muchidzidzo ichi, kupona kwevarume vakabata neTatotere panguva imwecheteyo sekuti Lupron aiva nemwedzi 18 yakareba kupfuura varume vakambobatwa neLupron chete.
Migumisiro yeimwe, kutongwa kwakafanana, kunonzi STAMPEDE (Systemic Therapy inokurudzira kana Metastatic Prostate kanhi: Kuongorora kweDrug Efficacy muedzo), yakabudiswa pamusangano weSCO wa2015.
Muchidzidzo ichi chemangwana anenge 3000 achangobva kuongororwa, varume vane humoni, hafu yevarume vakapiwa nokukurumidza Taxotere pamwe neLupron. Kupona kwavo kwakaenzaniswa neimwe hafu iyo yakambobatwa neLupron chete. Sezvakaitwa muHURARTED kudzidza, boka rechipiri iri rakarapwa neTareotere mushure mokunge Lupron ikamira kushanda. Uye zvakare, sekuita kwechirongwa cha CHAARTED, varume vakatanga Taxotere vasati vasangana nekusangana kwehomoni vakararama kwenguva refu.
Saka kunyange zvazvo Taxotere isati yave yakagadziriswa, muhutano hwezuva nezuva hwevarwere vane kenza yeprostate, nenzira iyo mamwe maitiro emishonga matsva (saZytiga, Xtandi, Xofigo, uye Jevtana) anosarudzwa kazhinji anotevera zvakanaka- yakasakara, sequential pattern.
Kushandisa mishonga kunze kwekuenzanirana kana kushamwaridzana kunowanzosvibiswa. Nzira inowanzosvibiswa kune iyo, "Nguva dzose yakaitwa nenzira iyo."
Vanachiremba vanoshandisa kufunga kwakanyanyisa kwezvikonzero zvezvikonzero zvakawanda uye kwete nguva dzose kuongorora "kunze kwebhokisi," nzira dzokurapa. Zvisinei, kunyanya iye zvino kuti vazhinji vatsva uye vashandi vanobudirira vari kubvumirwa neDWD, kushandisa zvirwere nenzira inotenderera inokanganisa zvingakundikana kuwedzera kukwanisa kwezvinhu izvi zvitsva zvekare.