Nzira Dzipi Dzinogona Kudzivirira Kanzerwe Chechikadzi neLynch Syndrome
Chii chaungaita kuti udzivise kenza muzvikadzi zvechikadzi (gynecologic cancers) kana une Lynch syndrome?
Munguva inosuruvarisa hatina nzira dzekudzivirira kenza yevanhu vane Lynch Syndrome-kana pasina Lynch syndrome nekuda kwechinhu ichi-tinoziva zvimwe zvezvinhu zvaungagona kuita izvo zvinogona kuderedza dambudziko rako rekudzidzira kenza yemaruva emuviri kana chibereko .
Isu tinozivawo nzira dzekuongororwa nekenza yevakadzi, uye nokuita kudaro, tariro yekuwana makondombera aya pane mamwe mapepa anonyatsoporesa.
Overview
Lynch syndrome inozivikanwawo kuti haina nhaka inonzi nonpolyposis colorectal cancer syndrome (HNPCC) . Izvo zvakagadzirirwa nhaka umo kusakanganiswa kwemajeni kunogona kuderedzwa kubva kumarudzi kusvika kune mamwe marudzi.
Iyo chirwere chinobatana nekushanduka kwemajini mana: MLH1, MSH2, MSH6, uye PMS2. Izvi zvinoshandiswa nemagariro zvakatora nhaka muzvigadzirwa zvemotokari, zvinoreva kuti iwe unongoda kugara nhaka yegene mutated kubva kune umwe wevabereki vako kuti utarise ngozi yakawedzerwa yehutano. Lynch syndrome inokonzera vaviri kusvika kune manomwe muzana yekenza yekoloni, uye muvhareji wemakore ekurasika kenza yemaroni ndeye 45 kune mumwe munhu ane Lynch syndrome.
Cancer Risks
Kazhinji kenza yakaipa yevanhu vane Lynch syndrome inosanganisira:
- Kanzera yeColon - 80 muzana
- Kanzera yemudumbu - 11- 18 muzana
- Chiropa uye chirwere chinokonzera bhati - 2 kusvika ku7 muzana
- Chirwere chepachiva uye mutsva - 4.5 kusvika ku5 muzana
- Kenza yemukumbo - 1 kusvika 4 muzana
- Kanzera yebongo - 1 - 3 muzana
Ngozi yepachiviri chechirwere chepachiviri chinosanganisira:
- Chirwere chekuberekwa - 20 kusvika ku60 muzana yevakadzi
- Kenza yeOvarian - 9 kusvika ku12 muzana yevakadzi
Izvi zvinotungamirira vanhu kune dzimwe mimwe zvirwere pamwe chete, zvakadai sekenza yemazamu .
Kupedza Dambudziko reKenza
Kana uchitaura nezvekudzikisa ngozi, zvakakosha kutanga kutanga mutsauko. Kunyanya kuongororwa miedzo yaunenge uchinzwa pamusoro payo ndeye fomu yekuona kare. Iyi miedzo haidzivirire kenza, kana kuderedza ngozi iyo iwe uchava nekenza. Pane kudaro, vanowedzera mukana wekuti kenza ichawanikwa apo iri duku. Uye kanzira dzakawanda dzinoporesa, uye zvichida kunyange dzinoporesa, kana dzichiri duku.
Kusiyana, pane zvinhu izvo vanhu vanogona kuita kuti vaderedze njodzi yavo yekuva nekenza pakutanga. Kudya kudya kwakanaka uye kudzidzira kunowira munharaunda iyi. Kuongorora kwekenza yeColon, zvisinei, zvakasiyana zvikuru pakati pekenza kuongorora kuongororwa. Inopa mukana wekuwana kenza kare-kutanga kuonekwa-asi kunogonawo kubatsira mukudzivirira, apo kunononoka kwemakumbo kunowanikwa, uye kubviswa, vasati vatanga kuva kenza.
Gwara reKancer Mekudzivirira Matanho
Zvakakosha kucherechedza kuti vakadzi vane Lynch syndrome, kuwedzera kune mamwe matanho achakurukurwa, vanofanira kuongororwa nekenza miedzo iyo vakadzi vasina Lynch syndrome vanogamuchira. Izvozvi, izvi zvakakosha kukuyeuka, sezvo zvichikosha kutarisira nhau dzehutano dzinogona kuitika kana iwe usina Lynch syndrome.
Semuenzaniso, vakadzi vane kenza yepabonde yepabonde dzimwe nguva vanonyanya kutarisa kudzivirira kenza yevana kuti vanokanganwa kutevera kuvhara maitiro ekudzivirira kenza yekoni sezvo ichiita se "isina kukosha."
Kuchengeta izvi mupfungwa kunokosha kuvadzimai vane Lynch syndrome kuti vataure nachiremba wavo nezvoutano husinganzwisisiki hwakasiyana neLynch syndrome. Semuenzaniso, zvichiri kukosha kutaura pamusoro pekudzivirira chirwere chemoyo kunyange zvazvo chirwere ichi chisingaiti dambudziko remwoyo, nokuti munhu wese ari pangozi.
Zvimwe Zvidzidzo Zvokudzivirira zvevakadzi neLynch Syndrome
Kuti uone kuti zvii zvinogona kutorwa kuti kuderedze mikana yekugadziriswa nehuwandu hunowedzera hutachiwana hweLynch syndrome, vatsvakurudzi vakatarisa zvinogona kubatsira zvekuverengera miedzo yekuongorora.
Kuderedza Ovarian uye Uterine Cancer Risk
Kune zvipo zvakasiyana-siyana zvakasiyana zvekuderedza dambudziko rekufa kubva kune ovarian kana uterine kenza yevakadzi vane Lynch syndrome.
Mukuongorora kwaka2006 kwakabudiswa muNew England Journal of Medicine , vatsvakurudzi vakapedzisa prophylactic hysterectomy nemagariro e-salopingo-oophorectomy ndiyo nzira inobatsira yekudzivirira endometrial (uterine) uye kenza yevana mavari mune vakadzi vane Lynch syndrome. Chidzidzo che2011 chinotarisa mukutsvakurudza kwezvinhu zvakasiyana-siyana zvakawanikwa, chirwere chekuchera kunjodzi kunonyanya kukosha.
Kubva kuva mupepeti wako zvakakosha pakuwana kurapa kwakanakisisa kunogona kuitika, zvinogona kubatsira kuziva apo zvimwe zvezvikurudziro zvinobva. Zvadaro, uye mushure mokuenzanisa zvisarudzo zvakasiyana nezvido zvako pachako, iwe unogona kuita chisarudzo chakanaka iwe pachako.
Vatsvakurudzi vakatarisa nzira dzakasiyana-siyana dzekudzikisa dambudziko rekufa kubva kune aya kanzira. Zvimwe zvinhu zvakamboedzwa zvinosanganisira:
- Ongororo yegore negore
- Kuongorora kwegore negore uchishandisa biometric endometrial , transvaginal ultrasonography, uye serum CA 125
- Kugadziriswa kubviswa kwechibereko, maovha, uye fallopian tubes pazera remakore makumi matatu (kana kuti zvisati zvapera makore makumi matatu)
Vatsvakurudzi vakatsanangura kuti nzira inonyanya kushandiswa (kuvhiyiwa) yakaguma nechinetso chemukondombera chepamusoro uye chisarudzo chisingaitiki (kuongororwa kwegore negore) kwakaguma nekanyanya kukonzera kenza. Izvi zvakabata chokwadi kune zvose mavari uye maitiro euketini. Asi, kunyanya kupona hakuna kuchinja zvakawanda. Pavhareji, vakadzi vakanga vane chibereko chavo, mavhavhai, uye fallopian tubes vakabviswa pazera remakore makumi matatu vakagara makore matatu kure gare kune avo vaiva negore rekuongorora gynecologic.
Kunyanya, kenza yemuvhara inowanikwa mumapfumbamwe ezana yevakadzi vaive vachiongororwa gore negore, vana mazana avo vaive nekuongorora gore negore, uye pasi pe1,50 yezana yevakadzi vaivhiyiwa. Chirwere chekuberekwa chakaitika muna 49 muzana yevakadzi vaiongororerwa gore negore, 18 muzana avo vaive nokuongorora gore negore, uye pasi pe1% yezana yevakadzi vaivhiyiwa. Kunyange zvazvo ichiita sechisinganzwisisiki, zvichiri kukwanisika kuti vakadzi vave nevana kana chirwere cheuterine kana nhengo idzi dzabviswa. Chiitiko ndeye peritoneal carcinoma.
Vakadzi vaiva nedambudziko regore negore vairarama kusvika kune 77, avo vaiongorora gore negore vakararama kusvika ne79, uye avo vakazovhiyiwa vakararama vanenge 80.
Kuderedza Dambudziko Revamwe Kanza
Kune zvakawanda zvekufungisisa kwevanhu vane Lynch syndrome yekukurumidza kuona mamwe kanzira. Somuenzaniso, gore negore kana bhayearly colonoscopies inokurudzirwa kutanga pazera remakore makumi maviri kusvika kumakumi maviri kana mashanu kana makore mashanu pasi pezera apo hama yakagadzira chirwere chacho. Taura nachiremba wako pamusoro pezviedzo zvekuongorora kuti uone zvakakunakira iwe.
Sources:
American Society of Clinical Oncology. Cancer.Net Lynch Syndrome. 12/2004. http://www.cancer.net/cancer-types/lynch-syndrome
Bonis, P., Ahnen, D., naL. Axell. Lynch syndrome (chirwere chisingawaniki chepolyposis chirwere chekare): Kuongorora uye kutungamirira. UpToDate . Updated 05/12/16.
Chen, L., Yang, K., Little, S., Cheung, M., uye A. Caughey. Gynecologic Cancer Prevention muLynch Syndrome / Hereditary Nonpolyposis Colorectal Cancer Families. Obstetrics uye Gynecology . 2007. 110 (1): 18-25.
Schmeier, K., Lynch, J., Chen, L. et al. Prophylactic Surgery kunoderedza Dambudziko reGynecologic Cancers muLynch Syndrome. New England Journal of Medicine . 2006. 354 (3): 261-9.
Vasen, H., Ignacio, B., Aktan-Collan, K. et al. Nhungamiro yakarongeka yekliniki yekuchengetedzwa kweLynch syndrome (HNPCC): zvinokurudzirwa neboka reongororo dzeEurope. Gut . 2013. 62 (6): 812-23.
Yang, K., Caughey, A., Little, S., Cheung, M., naL. Chen. Kuongorora Kunobatsira-Kubudirira kweProphylactic Surgery Kusiyana neGynecologic Kuongororwa Kwevakadzi kubva kuHereditary Non-Polyposis Colorectal Cancer (HNPCC) Mhuri. Familial Cancer . 2011. 10 (3): 535-43.