Pakava nemakakatanwa mazhinji pamusoro pekuti zita rekushandisa uye zita rechirwere rinopesana nemaperembudzi ndizvo zvinonzi "therapeutically equal." Mune mamwe mazwi, pane mimwe mibvunzo kana mishonga yemishonga inobatsira inoshanda pamwe chete nevaya vanowanzokodha mari-mazita nevamwe. Kana iwe uchifunga kuchinja kubva kune zita rechirwere chemishonga kusvika kune aniconvulsant mishonga yemishonga, kana kunyange iwe uri kutarisa kushanduka kubva kune imwe mishonga yemishonga kune imwe, unofanirwa kunyatsoziva nyaya iyi kuitira kuti uite chisarudzo chakanaka.
Zvechokwadi, iwewo unoda kuva nechokwadi uye kurukura nechisarudzo ichi nechiremba wako.
Kuti Mishonga Yakawanda Inotamba Sei
Apo kambani yemishonga inokura mishonga mitsva, inowanzodira mamiriyoni emadhora mukutsvakurudza. Iyi nzira inodhura inobatsira kuona kuti mushonga unosangana nemigumisiro inogamuchirwa yekudzivirira uye kubudirira. Kambani yezvinodhaka inogona kupa mhosva yekubhadhara mari yakawanda yezita idzva remishonga yemishonga. Anenge makore makumi maviri mushure mekunge purofesa yekutanga ichiiswa, kambani yemishonga inorasikirwa nekodzero yokupararira chete kwemishonga iyoyo. Mune mamwe mazwi, mamwe makambani anogona kupa shanduro ye generic yemishonga pamutengo wakaderera.
IUnited States Food and Drug Administration inoongorora zvose zvinogadzira maitiro e antiepileptics kuvimbisa kuti mishonga inoshandurana nemakiti emhando. Pasinei neizvi, kuongororwa kwechiremba uye nhoroondo dzemhosva zvinoratidza kuti pane matambudziko makuru pakushandura mazita ekurwisa antiepileptic kumishonga.
Kana FDA iri kunyanya kuedza pakuedza, ingave sei kuti vanachiremba vakawanda nevarwere vari kutaura zvinetso?
Kunetseka mukushanduka
Dhiyabhorosi inoona chirwere chinowanzoitwa "kuva chetachirairo" kune zita rezita rechirwere kana rine chiyero chakafanana chechigadziro chinoshanda, uye rinosangana nemirairo yesimba, unhu, utsanana, uye huzivi.
Zvinhu zviviri zvinonyanya kuongororwa:
- Nzvimbo-pasi-the-curve (AUC)
- Mafungiro akawanda eparma (Cmax).
Izvi zvinoratidza kuti mishonga yakawanda inopinda sei muropa. I-FDA inoda kuti AUC neCmax yemishonga inotsiva mishonga ive mukati ma80 muzana kusvika 125 muzana yezvinonzi zita-mazita nema 90 percent kuvimba. Izvozvo zvinoratidzika sechidimbu chakaisvonaka, kunyanya kana mushonga uri mubvunzo une zvishoma "maawa ekurapa" - musiyano pakati pemushonga wemishonga unoshanda uye mushonga wemishonga unokonzera kusagamuchirwa nemigumisiro.
Mukuwedzera, miedzo yekusimbisa kuti zvinodhaka zvinokonzera izvi zvinowanzoitwa kune vanhu vanenge 35. Iyi yakaenzana zvakasiyana pane iyo kazhinji mazana evanhu akaedzwa nokuda kwezita remishonga.
Chii chinonzi FDA State Nekutsvaga kuGeneric Medications?
Iyo FDA yakataura kuti hakuna humwe humwe hwakasimba hunoratidza kuti kune ngozi dzakawedzerwa dzekushandura kune zvekare. Vamwe vatsigiri venzvimbo iyi vanoratidza kuti chimiro chisingaiti chinogona kuita nharo mumatambudziko akataurwa nevarwere mushure mekushanduka. Kunyange zvazvo nzvimbo iyo inokonzerwa nayo inosanganisira zvirwere zvevarwere zvinovandudza mushure mekugamuchira chinhu chisingaiti (semushonga wepiritsi) nokuti murwere anofunga kuti chinhu chichavabatsira, kusanganisa kunosanganisira zviratidzo zvevarwere zvinowedzera kudarika nokuti vanofunga kuti mushonga unoshanda hauzobatsiri.
Zvose zvakaoma kutaura - zvichida kushungurudzika uye kuzvidya mwoyo kunobatanidza nekushandura kunowanzokonzera kubatwa mune vamwe vanhu vane hosha.
Kunyatsoongorora Generic Anti-Epileptics
Zvisinei, kana kusava nekubudirira kunongobatanidzwa nekudzvinyirira kwekushandura mishonga, hazvishamisi kuti migumisiro yakafanana haina kuonekwa mune mamwe marudzi emishonga semishonga inorwadza . Nei izvi zvichifanira kunge zviri dambudziko kune varwere vanotora mishonga yekufa? Zvinogona kungove kuti vanopesana nemaputi vanodikanwa zvakadzama kuttwa kwechirwere uye kuti zviyero zvakasimbiswa neDFA hazvishandi pamwe chete nemishonga nemawindo maduku ekurapa.
Muchiitiko ichi, dambudziko harisi rimwe rekushandura zita rechirwere kune mishonga inogadzirwa, asi inogonawo kuvapo kana uchitanga kubva kune imwechete kune imwe, sezvo izvozvi zvingave zvingave zvakasiyana. Somuenzaniso, kana imwe mishonga inowanzoita 125 muzana inoshanda inowanikwa muzita rainzi anti-epileptic, uye iwe unoshandura kune mishonga ine 80 muzana iyo inonzi, mushonga wako chaiwo wemishonga wakawa zvikuru.
Zvinogona kuisa njodzi
Njodzi dzekushandura zita rechigadzirwa kuva generic kana pakati pe generic dzichavimba zvizere nemishonga inotorwa. Varwere vachishandisa Keppra (levetiracetam), Lamictal (lamotrigine) kana Divalproex vanogona kunge vachidzoka kubva kuzvigadzirwa zvezita rechigadzirwa, zvinowanzowedzera kukanganisa kana kuti kuchinja kwekusagadzikana kwemishonga. Kuchenjerera kwakanyanya kunonziwo kana kubatwa kunogona kuva nengozi zvikuru, yakadai sevanhu vanofambisa, vane pamuviri, kana kuti vakatambura nemigumisiro yakaipa yekugumburwa kwavo munguva yakapfuura.
Pasi Pasi
Zvinetso zvinonzi zvinoshandiswa nekushandura kubva muzita rechirwere antiepileptic mishonga hazvirevi kuti zvose zvinorwisa kupemesa mishonga inofanirwa kumira. Kungofanana nedzimwe mimwe mishonga, pane zvingangove zvipingamupinyi uye zvinobatsira kuchinja kune ma generics. Izvi zvinotyisa uye zvinobatsira zvinoda kunzwisiswa zvakanaka vasati vasarudza kushandura. Mari ichaponeswa, asi pangangodaro kune zvimwe zvinetso zvaunoda kuziva kana kuti kuchinjwa kwechirwere chichadikanwa kuitwa. Zvakakosha kuziva kuti zvinokonzerwa nezvinetso zvakadini kunyange paunoshandura pakati pemishonga inobatsira uye kurukura zvose zvaunosarudza uye zvinetso newachiremba wako.
Sources:
American Epilepsy Society (AES) 65th Musangano Wegore Negore: Musangano weguta reDDA. Yakapiwa musi waDecember 2, 2011.
Gidal, BE (2012). Generic antiepileptic drugs: Zvakanaka zvakadini zvakakwana? Kurwara Kwechifupa, 12 (1): 32-34.
Henney, JE. (1999). Kubva pakudya nekushandisa zvinodhaka. JAMA, 282 1995.
Kramer, G., Steinhoff, BJ, Feucht, M., Pfafflin, M., & May, TW (2007). Chiitiko nemishonga inowanikwa muhutano varwere: kuongorora kwemagetsi kwemajeri eGermany, Austrian uye Swiss mapazi eILAE. Epilepsia , 48 (3): 609-611
Krauss, GJ, Caffo, B., Chang, Y.-T., Hendrix, CW, & Chuang, K. (2011). Kuongorora bioequivalence ye generic antiepilepsy drugs. Annals of Neurology , 70: 221-228. doi: 10.1002 / ana.22452
ZVINOKUDZIDZA: Mashoko ari panzvimbo ino ndeongangwa dzekudzidzisa chete. Icho hachifaniri kushandiswa sechinzvimbo chekuchengetedza iwe pachako nechiremba ane chiremba. Ndapota ona chiremba wako kuti aongororwe uye kurapwa chero kupi zvako pamusoro pezviratidzo kana chirwere chechiremba .