Zvingaita here kuti chirwere cheshuga muBS chive chakafanana neBile Acid Malabsorption Matambudziko?
Mukutsvaga kunzwisisa kwakadzika kwezvinhu zvinokonzera kushungurudzika kwebhood syndrome (IBS), vamwe vatsvakurudzi vakatora pfungwa yavo kune imwe inonzi idiopathic bile acid malabsorption (I-BAM).
Chii ini I-BAM?
Bile acids zvinhu zvinokonzerwa nechiropa chako uye zvakachengetwa muuru yako. Bile acid inobatsira nzira yekuchera mafuta, izvo zvinoitika mukati memukati mako maduku.
Kazhinji, iyo bile acids inobatwa nemukomana muduku uye inodzokera kuchiropa ichidzorerwa zvakare uye inoshandiswa yakawanda kanomwe pazuva. Chero shoma shoma ye bile acid (5 muzana) inowanzopfuurira kusvika kumakoloni, mumukaka mukuru .
Asi kana yakawanda yakawanda bile acid inopinza nzira yayo mumukumbo mukuru, inokurudzira kushandiswa kwemvura, zvichiita kuti zvive zvakasununguka, mvura uye marara. Iyi mamiriro anozivikanwa se bile acid malabsorption (BAM). Mukusabatwa kwechinhu chipi nechipi chinoratidzika mukati mechirwere chepachiviri kana kukuvadzwa, malabsorption inoratidzika seChipiri 2 BAM, zvichida inonzi idiopathic kana kuti primary BAM (I-BAM kana P-BAM).
I-BAM inowanzofungidzirwa sechinhu chisingawanzoitiki. Zvisinei, kuongororwa kwekutsvakurudza kwakawana kuti anenge 25 kusvika ku30 kubva muzana yevarwere vane IBS-D dzinoratidzira zviratidzo zvakaedzwa zvakanaka nokuda kweI-BAM vachishandisa 75SeHCAT scan.
Sezvimwe chikamu chekuongorora uku, deta yakaratidza kuti varwere vanopiwa mishonga inotorwa mishonga ye bile acid sequestrants inoratidzika nehuwandu hwema malabsorption sezvinoyerwa nemishonga ye nyukireya kuenzanisa kuratidza zviratidzo zvekuvandudza.
Vatsvakurudzi vanogumisa kuti kusazivikanwa kweI-BAM nekuda kwekusaziva pamusoro pekupararira kwayo nekushaikwa kwekuwana scan (hakuwanikwi muU.S.) kunogona kutungamirira kune vakawanda va-IBS-D varwere vasingagamuchiri kurapa kwakakodzera uye kwakanaka .
Imwe Imwe Inogona Kubvira
Vatsvakurudzi vanga vachiedza kuenderera mberi kunzwisisa chii chingave chiri shure kweiyo bile acid malabsorption dambudziko.
Chimwe chingave chinokonzerwa neaal (tumukumbo duku) hormone, FGF19, iyo inotarisirwa kudzora bile acid inogadzirwa. Zvinogona kunge zvakaderera mazinga ehomoni izvi zvinokonzera kuwandisa kwakanyanya kweBacid acid inokonzera kupararira mumatumbo makuru. Kutsvakurudza kuri kuenderera mberi kunonzwisisa zviri nani kusakosha uku, netariro kuti inogona kutungamirira kumishonga inonyatsotarisa dambudziko racho.
The Bottom Line
Sezvinonakidza apo nhamba dze25 kusvika ku30 muzana dzinokosha, zvinokosha kuziva kuti iyi nzvimbo yekutsvaga inoita seinoendeswa neboka rimwe revatsvakurudzi. Uye, zvinosuruvarisa, sezvo 75SeHCAT scan isingawanikwi muUnited States, hazvisi sekuti pane kukurumidza kuongororwa ropa kuti uone kana IBS-D yako chaizvo I-BAM. Zvisinei, kana iwe uchiramba uine rusununguko, mvura yakadzika sechikamu chechimiro chako chechiratidzo, unogona kuda kutaura nachiremba wako kuti uone kana iwe ungadai uri mumiririri wekutongwa kwemishonga inoshandiswa kurapa BAM.
Sources:
Pattni, S. & Walters, J. "Kufambira mberi munguva pfupi muku kunzwisisa kwe bile acid malabsorption" British Medical Bulletin 2009 92: 79-93.
Walters, J. "Kujekesa primary bile acid diarrhea: kuita kuti kuongororwa uye kuziva chirwere" Ongororo Ongororo 2010 4: 561-567.
Wedlake, L., et.al. "Kugadziriswa kwakarongeka: kuwanda kweidiopathic bile acid malabsorption sezvakaonekwa neSeHCAT kuongorora kune varwere vane chirwere-chirwere chinokanganisa bowel syndrome" Alimentary Pharmacology uye Therapeutics 2009 30: 707-717.
Walters, J. "Kujekesa primary bile acid diarrhea: kuita kuti kuongororwa uye kuziva chirwere" Ongororo Ongororo 2010 4: 561-567.