Kunzwisisa Mafungiro Enhema A1C Miedzo muvanhu vane Hemoglobin Variants
Hemoglobin uye chirwere cheshuga zvine hukama huripo. Glucose inounganidza hemoglobin mumasero matsvuku eropa uye inogara imomo kwemwedzi mitatu. Kuwanda kweshuga yepa hemoglobin inoedzwa mu hemoglobin A1c test uye inonzi iyo EAG nhamba. Nhamba iyoyo, zvisinei, inokanganiswa nehuwandu hwemashuga ako ega, uye kunzwisisa mazinga ako zvakakosha kunzwisisa pfungwa shomanana.
Hemoglobin uye chirwere cheshuga chakabatana sei, uye nguva yako yekuongorora A1c ingave isina kururama?
Chii chinonzi Hemoglobin?
Hemoglobin ipuroteni mumapurogiramu mumasero matsvuku eropa anotakura oksijeni kubva mumapapu ako kune zvikamu zvose zvemuviri wako. Inenge yose ye okisijeni muropa rako inotakurwa pa hemoglobin, saka inokosha zvikuru. Iine iron uye ndizvo zvinoita kuti masero matsvuku eropa aite ruvara. Paunenge uine "iron-mashoma ropa" inokonzerwa nekushaya hemoglobin yakakwana mumasero ako matsvuku.
Hemoglobin Inoshandiswa Kuedza Sei Chirwere Cheshuga?
Paunenge uchidya, muviri wako unoputsa makungu ehydrohydrates makuru mukati meglucose kana shuga inoshandisa simba. Izvozvo zvinoguma muropa rako kuitira kuti rikwanise kutakurwa kumativi ose emuviri wako. Zvimwe zvehuga zvinopedzisira muropa rako zvinomira kune hemoglobin pamasero matsvuku eropa uye unogara ipapo kwemwedzi mitatu. Yakawanda yemasero ako matsvuku anoshandiswa zvakare shure kwemwedzi mina, saka masero ako anoratidza chete mhoroondo yemwedzi mitatu yapfuura.
Kana iwe wakasimudza huwandu hwehuga muropa rako, sevanhu vakawanda vane chirwere cheshuga vanoita, zvino zvakawanda zvekuti shuga ichabatanidza nemasero matsvuku eropa. Iyo yakasimudza muzinga wehuga muropa rako, iyo inowedzera shuga inosungiridza hemoglobin yako.
Hemoglobin A1c Test uye Diabetes
Kuongorora kweropa rega rega zuva rose kunonyanya kukosha mubasa rose rehutachiwana hwehuga.
Asi, kuedza uku kunopa chete chidimbu chemuzinga weglucose muropa munguva yechipupuriro. Rimwe awa gare gare, chigumisiro chinogona kunge chakasiyana. Muedzo unonzi hemoglobin A1c (kana kuti glycohemoglobin test) inopa maonero akawanda kwenguva yehutachiona nekuyera kuti glucose yakawedzerwa sei hemoglobin pamusoro pehupenyu hwemuviri weropa tsvuku, iyo inenge mwedzi mitatu. Iko kunofungidzirwa yegoridhe muedzo wekutsvaga kuti unzwisise mazinga emakore ekuglucose muropa uye inokurudzirwa neAmerican Diabetes Association. Inoshandiswawo sekuongorora kuongorora chirwere cheshuga.
Hemoglobin Variants Inobatsira Test A1C
Chiyero cheA1c hachina kururama kuvanhu vane maitiro akasiyana-siyana e hemoglobin. Iyi miedzo yakagadzirirwa vanhu vane hemoglobin A, rudzi rwakakurumbira rwehemoglobin. Izvi zvakasiyana-siyana zveHemoglobine zvinowanikwa (zvakagarwa) muvanhu vazhinji veAfrica, Mediterranean, uye Southeast Asia nhaka. Kunewo maitiro asina kukodzera ehemoglobine A. Kazhinji hemoglobin inoumbwa nemaviri Maketani kana maviri emaketani B. Kana imwe yezviketani izvi isipo (mhaka yakagara nhaka) mhedzisiro inotumidzwa inonzi thalassemia .
Mhando dzeHemoglobin dzinosanganisira:
- Hemoglobin S (inowanikwa nekwerele cell trait)
- Hemoglobin C
- Hemoglobin E
- Hemoglobin F - Hemoglobin F inoona panguva yekuzvitakura, mumucheche uye pane dzimwe nguva pamuviri.
- Zvimwe zvakawanda zvishoma zvakasiyana-siyana zvakadai saHb D kana kuti G, Hb J, nezvimwe
- Carbamylated hemoglobin (inowanikwa nevanhu vane hosha kusakona)
Hasi zvisikwa zvose zve hemoglobin zvinotungamirira kumatambudziko ehutano, sezvaanoita nehanle cell cell, asi zvinogona kukonzera mhinduro dzakaipa pamwe nekuongorora kweA1c. Semuenzaniso, vanhu vane chirwere chechiremba-vane vatakuri ve sickle cell chirwere asi havana zviratidzo zvechirwere. Vachave, kunyange zvakadaro, vane kuverenga kusina kujeka pachidzidzo cheA1c.
Kukosha kweHemoglobin Variants uye Diabetes
Kana uine maitiro e hemoglobin, mikana ndeyokuti iwe uchawana kuverenga kwakanyatsonaka pakuongorora kweHbA1c kukuudza iwe nechiremba wako kuti shuga yako yeropa yakakwirira kwazvo, kunyange kana isiri.
Mukupindura kweizvi, chirwere cheshuga cheshuga kana chirwere cheshuini chinogona kuwedzerwa, kuedza kuunza chirwere cheshuga chinotungamirirwa zviri nani. Zvinosuruvarisa, kuwedzera uku kunogona kukonzera kushuga yakaderera ropa ( hypoglycemia ) iyo dzimwe nguva inogona kuve ine ngozi uye inofanirwa mune zvehutano.
Kuverenga kwenhema kunogona kuita kuti iwe nachiremba wako vatende kuti une chirwere cheshuga kunyange kana iwe usingaiti. Mishonga kana insulini zvingadaro zvatanga, iyo, sepamusoro, inogona kukonzera hypoglycemia. Emotionally, kusakanganiswa kusakanganisika kunogonawo kuva kunetseka zvikuru, kana iwe uchitenda une chimiro chausingaiti.
Ndiani Angave Ane Hemoglobin Variant?
Ndiani anofanira kuongororwa kuti aone kana vane hemoglobin variant? Vanhu vakawanda vanowanzova ne-hemoglobin yakasiyana vanosanganisira avo vano:
- Ndivo veAfrica, Mediterranean, kana Southeast Asia nhaka
- Itai kuti mhuri ive nhoroondo yemumwe munhu ane rudzi rwemhando ye hemoglobin
- Kana iwe ukashamiswa nemigumisiro yekuedza kwako A1c (somuenzaniso, kana yakakwirira uye kuverenga kwako kwave kwakanaka)
- Kana kuverenga kwako A1c kuchikwirira zvikuru
- Kana kuverenga kwako kweA1c kushanduka zvakanyanya nekushandura mubazi iro rinoita izvi
Kana uine ma-hemoglobin variant, iwe unogona kuva neHbA1c miedzo. Haasi maedzo ose anokonzerwa nemhando dzakasiyana-siyana dzehumoglobin, uye chiremba wako achadikanwa kuti uve nechiyero chako chakaitwa panzvimbo ino.
Inowanikwa sei Hemoglobin Variants?
Mune rumwe ruzivo rwakakura rwemarudzi akawanda eNorth America vanhu, 3.77 muzana yevanhu vakawanikwa vane hemoglobin variant. Pakati peizvi, zvimwe zvakasanganisira:
- HbS ( sickle cell trait ) - 2.85 muzana
- HbSS ( sickle cell disease ) - 0.03 muzana
- HbC muitiro - 0.61 muzana
- HbCC chirwere - 0.01 muzana
- HbSC - 0.04 muzana
- HBE - 0.13 muzana
- HbD kana G chiito - 0.6 muzana
- HbS B-thalasemia - 0.1 muzana
- Kuramba HbF - 0.01 muzana
- HbMontgomery - 0.01 muzana
Alpha thalassemia aivewo ari muna 3.82 muzana yeavo vane hemoglobin variants.
Zvimwe Zvimwe Zvingaita Kuti Upe Hemoglobin A1C Kuverenga
Sezvo hemoglobin A1c mazinga akatsigirwa nemasero matsvuku eropa, chero chinhu chinopindira (chinopera) upenyu hwemasero matsvuku eropa hunogona kukonzera migumisiro yakaipa. Somuenzaniso, kurasikirwa kweropa kunokonzerwa nekuvhiyiwa kana nguva huru yokuenda kumwedzi kana chirwere chakadai se hemolytic anemia chingaguma nekuverenga zvisiri izvo. Kurema kwesimbi kunokonzerwa nokuverenga kwakaderera, asi kushandiswa kwesimbi kushandiswa kunogona kukonzera mazinga akareba. Kana uine kuwedzerwa ropa, huwandu hwako hunogona kunge husina kururama. Hemoglobin A1c mazinga anogona kuva akaoma kududzira kuvanhu vane mafungiro asina kukwana nokuda kwezvikonzero zvakawanda.
Pasi Payo paHemoglobin Variants uye Hemoglobin A1C Nhamba
Iyo hemoglobin A1c level inokosha zvikuru mukugadzirisa muzinga weushuga weropa pane kwenguva yakareba. Zvinosuruvarisa, mahedheni e hemoglobin anogona kuita kuti kuedza uku kusakarurama, nokudaro kuderedza kusarurama.
Kana mazinga ako A1c asingaoneki asingagumi nemasikati ako ekuongorora, kunyanya kana iwe uri weAfrica, Mediterranean, kana Southeast Asia nhaka, taura nachiremba wako nezvekuita ropa rega rekuongorora ropa kuti uone kana une hemoglobin variant. Kuziva kuti iwe unopesana, iwe chiremba unogona kuve nechokwadi chekuti ropa rakaongororwa parebhu iyo yakashandisa nzira dzisingasanganiswi nezvinosiyana.
> Sources:
> Little, R., La'ulu, S., Hanson, S., Rohlfing, C., uye R. Schmidt. Migumisiro ye40 Kusiyana Rare Hb Variants paHbA1c Kuyera nenzira Eight. Zvinyorwa zveShuga yeSayenzi uye Technology . 2015. 9 (4): 849-56.
> Lorenzo-Medina, M., De-Iglesia, S., Ropero, P., Noqueira-Salqueiro, P., uye J. Santana-Benitiz. Migumisiro yeHemoglobin Variants paHemoglobin A1C Maitiro Anenzaniswa Kushandiswa Kwakawanda-Kuita Mushonga Chromatography Mitiro. Zvinyorwa zveShuga yeSayenzi uye Technology . 2014. 8 (6): 1168-1176.
> Hemoglobin Variants Izvozvo Zvingaita Kusiyana Kwakakosha muHemoglobin A1c Sekuenzaniswa neHigh-Performance Liquid Chromatography uye Enzymatic Methods muvarwere veSaabheti: Chidzidzo cheChipatara-Sectional. Annals of Clinical Biochemistry . 2016 Aug 5. (Epub mberi kwekudhinda).