Doxorubicin (zita rekutengeserana Adriamycin) rinowanzoshandiswa chemotherapy agent rinoshanda zvikuru muHodgkin uye Non-Hodgkin lymphomas . Iyo inoshandiswa munenge mishonga yose yekutanga chemotherapy inokonzera lymphomas. Icho chiri chekirasi yemakemikrasi yemishonga inonzi anthracyclines.
Doxorubicin May Anoita Mwoyo Kukuvara
Zvinonyatsozivikanwa kuti doxorubicin inogona kukanganisa mwoyo mune vamwe vanhu.
Kunyange zvazvo mamwe anthracyclines (sepirubicin uye mitoxantrone) inogonawo kukonzera mwoyo kukuvadza, mikana yakawanda zvikuru ne doxorubicin. Doxorubicin inokonzera zvose kukanganisa nekupera kwemoyo wemwoyo (inonziwo cardiotoxicity). Kuparara kwekutanga kunowanzoitika pakarepo mushure mekushandisa mishonga yekushandisa mishonga kana mukati memakore 1 kusvika ku2 Pane zviduku zvitsva zvinotorwa pa electrocardiogram (EKG) uye mumatambudziko akawanda kusarudza pasina kukonzera matambudziko makuru. Iko kunonoka-kutanga kukanganisa kunokosha uye kwakanyanya.
Zuva reCardiac Damage
Kuora kwemazuva mashoma kumwoyo kunotanga gore kana kupfuura pashure pemakemikari. Doxorubicin inonyanya kukanganisa mwoyo musumbu. Icho chinotadzisa mwoyo mutsvuku uye inoita kupomesa ropa kunorema mwoyo. Kana zvakanyanya, zvinotungamirira kumamiriro ezvinhu anonzi congestive heart failure (CHF). Vanhu vane CHF vanonyunyuta nezvezviratidzo zvakawanda
- Kuoma kunowedzera kuwedzera kunetseka mubasa rakaoma, zvichiita kuti aneta kana kuti kufema kunetseka paanokwira matanho kana kufamba
- Chifukidzi chinowedzera usiku
- Kutamba kwetsoka
- Dambudziko mukufema pazororo
Kana zvakanyanya, CHF inogona kukonzera kuremara kwakanyanya uye kunyange rufu.
Doxorubicin Inokuvadza Mwoyo Sei?
Doxorubicin inopindirana nemamwe makemikari mumuviri (anonzi enzyme) kuti aite zvinhu zvinokuvadza zvinonzi radicals vakasununguka. Kubudiswa kwezvinhu izvi zvinokuvadza zvakasununguka kunosimbiswa mumitambo yakafanana nemoyo umo mune hunijeni uye iron.
Nepo dzimwe nhengo dzine mazivo emuviri kuti aparadze idzi dzakasununguka dzisarudzo, mwoyo unenge uine hurombo hushoma hwemakemikari aya. Izvi zvinoita kuti mitsipa yemwoyo isvike pakuvhiringidzika nemasikirwo emhando dzakasununguka.
Zvinhu Zvinokanganisa Mwoyo Kukonzera
Zvinhu zvakawanda zvinowedzera mikana yekuvhiringidza mwoyo ne doxorubicin.
- Chirwere chakanyanya che doxorubicin chinowanzoita kuti mwoyo uparadze. Nhamba ye doxorubicin yakagamuchirwa mukati mehupenyu hwemunhu inofanira kunge yakakwana kudarika 400mg pamamita mita (yemuviri wepasi). Ngozi yeCF neyero iyi inopfuura 1 muzana. Pamusoro pemitambo yakakwirira, mikana yemwoyo inokanganisa kuwedzera. Nenzira yakanaka, mishonga ye chemo inoda kuderedza doses.
- Kushandiswa panguva imwechete kweimwe chemotherapy mishonga inokanganisa mwoyo, kureba kuwanda kwe cyclophosphamide
- Kupisa mazai kurapa kuchipfuva
- Chirwere chekare chiripo
- Muduku
- Vakadzi vechikadzi
Kuedza Mwoyo Kuparadza
Mhosva yemoyo inowanzoedzwa ne echocardiogram (inowanzonzi 'echo') kana kuti MUGA kuongorora kuti uongorore huwandu hweropa iyo mwoyo unokwanisa kubudisa. Mumashoko ekurapa, izvi zvinonzi 'chikamu chekusiya ventricular ejection' kana LVEF. IWVEF inotaridzirwa kune vanhu vazhinji vasati vatanga kurapwa kuti vatungamirire kunze kwechinetso chekutanga chemoyo.
Nokudaro, inogona kuyerwa zvakare panguva yekurapa uye nguva dzinotevera kuti uone kana kune kuwira muLVEF. Dzimwe nguva matambudziko emwoyo anogona kuratidza muKGG zvakare.
Nzira Dzokuderedza Kuparara
Kune dzimwe nzira umo mwoyo wekukuvara kunogona kudzivirirwa kana kuderedzwa
- Kuchengeta muwandu we doxorubicin mukati memiganhu yakachengeteka
- Kutarisira mishonga sechirwere mu saline pane kungoita jekisi
- Kushandisa chigadziro chitsva che doxorubicin chinonzi 'liposomal doxorubicin' - mishonga inouya yakavharwa mune mafuta akaipfekedza anonzi liposome. Iri kupfeka rinoputika mukati memukenza chete kusunungura mishonga. Nhengo dzakajairika sezvakaita mwoyo hazvibatsiri.
- Kushandisa chinhu chinonzi dexrazoxane sekudzivirira munguva pfupi mushure me doxorubicin. Zvinogona kuderedza mikana yekukuvara kwemoyo uye FDA inogamuchirwa mumuviri wepabonde wepakati.
Kurapa kweCCF
Kukundikana kwepfungwa kunokonzerwa ne doxorubicin kunobatwa pamiganhu yakafanana nedzimwe mhando dzekushaya mwoyo. Hakuchina mishonga inokosha ye doxorubicin-yakabatana mwoyo kukanganisa. Zororo, okisijeni nemapiritsi zvinoderedza zviratidzo zveCCF nekudzivirira hurema hwepfungwa. Zviratidzo zvakanyanya zvingada kubvumirwa kuchipatara.
Tinofanira Kusiya Kushandisa Doxorubicin?
Doxorubicin inobatsira kwazvo chemotherapy drug. Inobatanidzwa mukurapa kwekenza yakawanda. Kunyange zvazvo pane sangano rakakwana re doxorubicin rine kuora mwoyo, zvinobatsira pakushandisa doxorubicin zvinopfuura zvengozi. Mwoyo kukanganisa nemishonga iyi inonyatsonzwisiswa, uye kana doxorubicin inoshandiswa mukati memiganhu yakachengeteka, hapana chikonzero chekurega kushandiswa kwemishonga inobatsira seyizvi.
> Sources:
Kanzira - Maitiro uye Maitiro eOnology (7th Edition). Vakuru - Vicent T Devita Jr., Samuel Hellman, Steven Rosenberg. (Chitsauko 15: Pharmacology yeCancer Chemotherapy: Chikamu 7: Topoisomerase Interactive Agents.)
Doxorubicin Hydrochloride, National Cancer Institute, September 17, 2014.
Doxorubicin, Medline Plus, US National Library yemishonga, 01/15/2012.