Cyclic neutropenia inowanikwa nhaka iyo inonzi neutrophil count (white cell cell inorwisa mabhakitiriya zvirwere) inowedzera pasi (kazhinji pasi pemamiriyoni 500 / mL) mumhepo inenge inenge mazuva ose 21. Inowanzopa mugore rekutanga rehupenyu. Maitiro acho anoderera nezera uye inogona kupera mune vamwe varwere vakuru.
Ndezvipi Zviratidzo?
Apo nhamba ye neutrophil yakajairika, hapana zviratidzo.
Zviratidzo zvinowanzovhara shure neutropenia (yakaderera neutrophil count) zvinoreva kuti neutrophil nhamba yakatove yakanyanyisa kwazvo kwemazuva mashomanana kusati kwave nekuvandudzwa kwezviratidzo. Akarwisana nedzimwe maitiro ekubatana neutropenia (yakaoma congenital neutropenia, Shwachman Diamond Syndrome , nezvimwewo), kusununguka kuberekwa hakuoneki. Zviratidzo zvinosanganisira:
- Aphthous ulcers (ulcers mumuromo)
- Kusuruvara kunopisa (pharyngitis)
- Gum kuvimba (gingivitis)
- Zvirwere zvirwere
- Fever
Ndiani Ari Pangozi?
Cyclic neutropenia ndeyekusangana kunoreva kuti munhu anoberekwa ane chirwere. Yakapedzisira mumhuri mune mafashoni anozvigadzirisa zvakanyanya zvinoreva kuti mubereki mumwe chete anofanira kuchinjwa kuti apfuure kuvana vavo. Haasi nhengo dzemhuri dzose dzinogona kuchinjwa zvakafanana uye dzimwe dzingave asi dzimwe dzingave dzisina zviratidzo.
Inozivikanwa Sei?
Cyclic neutropenia inogona kuva yakaoma kuti iongorore sekuti neutropenia yakanyanya inopedza mazuva matatu kusvika ku6 panguva imwe neimwe.
Pakati pezvinongororwa izvi, zviyero zve neutrophil zvakajairika. Zvirwere zvepachivi zvinowanzoitika uye fever mazuva maviri kusvika kwemazuva gumi nemasere anofanirwa kusimudzira kusafungidzirwa kweyclic neutropenia. Kuti tibate mhirizhonga ye-neutropenia yakaoma, kukwana kweropa kuwanda (CBC) kunoitwa 2 kusvika ku3 pavhiki kwevhiki 6 kusvika ku8.
Mukuwedzera kune neutropenia yakaoma, kunogona kuderera mumasero matsvuku eropa (reticulocytopenia) uye / kana platelets (thrombocytopenia).
Iko monocyte count (imwe mhando yeganda rega rega ropa) rinowanzowedzerwa munguva yenguva yakakura yeutropenia.
Kana cyclic neutropenia inenge ichifungidzirwa zvichienderana nehuwandu hwehuwandu hwemagavi, kuongororwa kwemashoko kunofanira kutumirwa kutarisa kuchinja kwemuviri weE ELANE gene (pane chromosome 19). 90 - 100% varwere vane cyclic neutropenia vane ELANE mutation. Kuchinja kwemuviri muEELANE geni kwakabatanidzwa ne-cyclic neutropenia uye yakaoma congenital neutropenia. Zvichipa kliniki yehurukuro uye kuvimbiswa kwema genetic test, bone marrow biopsy haitariswi asi inowanzoitwa panguva yebasa-up neutropenia.
Chii Chinonzi kurapa Options?
Kunyange zvazvo cyclic neutropenia inofungidzirwa sechiremera, rufu rwechipiri kune hutachiona hwakakomba hwakaitika. Mishonga inofanirwa kudzivirira uye / kana kurapa zvirwere.
- Granulocyte Colony-Stimulating Factor (G-CSF, inonziwo filgrastim): G-CSF inokurudzira marora emapfupa kuti abereke neutrophils akawanda. Inoshandiswa kudzivirira kuverenga kweutachiona kubva pakudonha pasi pe 500 masero / mL. G-CSF yakaratidzwa kuderedza kuoma kweeutropenia uye kuderedza nhamba yezvirwere. G-CSF inotungamirirwa pasi peganda (iri pasi peganda) mazuva ose kusvika ku2. Vamwe varwere vanogona kukwanisa kurega G-CSF semunhu mukuru nokuti dzimwe nguva neutropenia inowedzera simba nezera.
- Kudzivirira mazino ehutano: Nemhaka yehutachiona hwakawanda huri mumuromo, zvinokosha kuti urambe uine utano hwakanaka. Antibacterial mouthwashes inogona kukurudzirwa.
- Kuongororwa nefivha: Nokuti varwere vane cyclic neutropenia vanogona kukura maitiro epakitiriya akaipa, zvinokosha kuti zvikamu zvefivhiri zviongororwe zvakanyatsonaka. Dzimwe nguva, zvikamu zvichange zvichitsvaga kugadziriswa nemajoka (IV) ma antibiotics kusvikira utachiona hwehutachiona hunogona kubudiswa kunze.