Miti yedu ine hormones inodzora zvikamu zvose zvemetabolism, uye izvo zvinosanganisira kudya uye kuyerwa kwemashoko. Hemoni dzakawanda dzakawanikwa dzakavhiringidza kudya uye kukura kana kudzivirira kuneta . Pane mahomoni mana akadai makuru: ghrelin , leptin, insulin, uye peptide YY (PYY). Nyaya ino inonyanya kutaura nezve leptin.
Chii Chinonzi Leptin?
Zvakarehwa, leptin ihomoni inoderedza kudya.
Izvo zvakanzi "satiety factor" nekuda kwechikonzero ichi. Leptin inobudiswa neadipose (mafuta) masero. Izvo zvakaenzana zvekugadzirwa kwayo zvinoenderana nemafuta emuviri. Apo mafuta emuviri anowedzera, saizvozvowo mazinga e leptin, ayo anobva ashumira kuti abvise kudya uye kuwedzera chidimbu chemagetsi. Apo mafuta emuviri anowa, saizvozvo mazinga e leptin, uye kudya kwechido zvinobviswa, kuisa chiratidzo kumuviri kuti yava nguva yekudya zvakare. Pakutanga, izvi zvakashandira chinangwa chokudzivirira nzara.
Leptin dzimwe nguva inofungidzirwa semumwe weghrelin pamwe nokuti ghrelin (chimwe chido-regulating hormone, chinogadzirwa nedumbu uye duodenum) chinokurudzira chido apo maitiro acho achikwira. Nemhaka yokuti leptin inogona kuderedza kudya kwekudya nokudzivisa kudya kudya, inogona kukonzera kuora muviri; zvinopesana nazvo, nokuti ghrelin inogona kuwedzera kudya kwekudya kuburikidza nekukurudzira kudya, kunogona kuita kuti uwedzere kuwedzera nekuwedzerwa.
Muna 1994, jeni rinobudisa leptin, rinozivikanwa sevanhu rakaoma ( OB ) geni, rakawanikwa naZhang uye vashandi pamwe navo mumiti.
Leptin yakanzi iine maitiro akawanda ehupenyu, kusanganisira zvirwere zvekudzivirira uye kupisa, kupindira mukutanga kwehupombwe hwevanhu, basa mumapfupa ekugadzira, uye basa mukurapa kwepakuvara, pakati pevamwe uye kuwedzera kune basa rayo mukurema kwekutema.
Chii Chinokanganisa Nhamba dzeLeptin?
Vatsvakurudzi vakawana maitiro anoverengeka uye zvinhu zvinogona kuwedzera kana kuderedza maitiro eptin mumuviri.
Kukura uye kuwandisa kwezvokudya kunoratidzika kuti kunobatsira pakusunungurwa kweLeptin kubva kune adipose tissue. Mukuwedzera, kuumbwa kwekudya kunokosha. Mune zvimwe zvidzidzo, somuenzaniso, kudya kwakaderera kwemafuta kwakaratidzika kunokonzera kukwirira kwakakura kwemaeptin kupfuura kudya kwemafuta. Panewo humwe humwe hutano hwokuti varwere vese vatova leptin-resistant, kana kusagadzikana nemigumisiro ye-leptin, uye nenzira iyo inowanzogadzirisa nzira yehupenyu inotaurira muviri kana yava nguva yekurega kudya yakanganisa.
Kurara zvishomanana kunogonawo kukanganisa maitiro eLeptin, zvichiita kuti zvikamu zviduku uye chido chikuru (kushanda pamwe chete ne ghrelin, sezvataurwa pamusoro apa). Kuwana maawa manomwe kusvika mapfumbamwe ekurara kusinganzwisisiki usiku hwose hunoita sekubatsira kuchengetedza mahara yeeptin apo inofanirwa kunge iri kupindura kudya.
Sezvo zvingafungidzirwa, pamusana pekukwanisa kwayo kukonzera kuora muviri, zvidzidzo zvakatarisa nenzira dzakasiyana-siyana dzokushandisa leptin uye mabasa ayo epa pharmacologic therapy ave achienderera kwechinguva uye ari chikamu chekutsvaga kutsvaga kubudirira kunorwisa kupererwa kwehutano hutano.
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