Majini ako awakagara nhaka kubva kuvabereki vako anoona kutaridzika kwemuviri wako, zvakadai somuvara weziso uye mavara, pamwe nemamwe maitiro, sopa rekuda uye kuswedera pedyo. Uye hazvisi zvose. Nhaka dzakakosha dzinogonawo kubatsira kugona humwe hutano hwako hunoita - sekudzivisa kenza yeprostate kusadzoka zvakare.
Nzira yeCrostate Cancer inokura sei
Androgens (varume vanorara sex hormone) vanoita kenza ye prostate kukura.
Nokudaro, androgen deprivation therapy (ADT) ndiyo imwe nzira yekurapa kenza yeprostate , kunyanya kana yakanyanyisa kana yakapararira. ADT inogona kusanganisira kutora mishonga inogadzirisa uyerogen kubva pakugadzirwa (mumatete) kana kudzivisa kuitika kwe androgen mumuviri wako wose. ADT inogonawo kusanganisira chirwere chokubvisa mapepa maviri. Inowanzoshandiswa kuwedzera kune mamwe maitiro ekurapa kenza yeprostate, zvakadai sedhiation therapy kana kubviswa kwe prostate.
ADT, chaizvoizvo, inobvisa mafuta uye inomisa masero ekenza yeprostate kubva pakukura - kana kuti zvishoma nezvishoma inodzikisa.
Asi, kakawanda, ADT inoshanda chete kwenguva refu. Masero emukenza eprostate anowanzova "kusagadzikana kusagadzikana" pakupedzisira. Vanotanga kuzviita ivo androgen, nokudaro vachizvidiridza ivo pachavo.
Varume vanogamuchira ADT yekenza yeprotate vane maitiro anowanzoitwa prostate-specific antigen (PSA) . Kukwidzika kwePSA maitiro kunogona kuratidza kuti kenza yeprotate yava kusagadzikana uye yakatanga kukura zvakare.
Zvitema Zvigadzirise Simba Rako Rokurwisa Kenza yeProstate
Vamwe varume vanogona kushandisa ADT kuchengetedza kenza yeprotate inenge yakareba kupfuura vamwe.
Chidzidzo che 2016 kuCleveland Clinic uye Mayo Clinic chakawana kuti varume vane mararamiro akasiyana ejeni chaiyo vanogona kuwana kenza yeprostate isingagadziriswi munguva pfupi. Mune varume ava, ADT haishande kwenguva refu.
Kenza yavo ichadzoka nokukurumidza.
Kunze kune 443 kenza yekenza yepirate mukudzidza, vose vakange vaine zvirwere zvakanyanya uye vakabatwa neDT. Vamwe varume vakanga vane "zvakajairika" HSD3B1 mageti - mairi maviri, imwe kubva kumubereki mumwe nomumwe. Zvimwe zvakanga zvakasiyana, HSD3B1 (1245C), asi kubva kune mumwe mubereki. Kunyange zvakadaro vamwe vaiva nechinja chakasiyana kubva kuvabereki vose.
Mamwe mapepa emhando dzakasiyana-siyana, ADT shoma yakashanda.
Vaya vane "maitiro" anowanikwa muCleveland Clinic boka revarwere vakamisa kenza yeprostate kubva kune imwe miviri yemakore 6.6. Asi vamwe havana kufanirawo. Avo vane maitiro akasiyana-siyana kubva kune mumwe mubereki vakaramba vachidzoka zvakare pakati pemakore 4.1. Avo vane mararamiro akasiyana-siyana kubva kuvabereki vose vari vaviri vakaramba vachidzokorora mumwe wemakore anenge 2.5 chete.
Une Misi Yakasiyana Here?
Maererano ne1000 Genomes project, inenge hafu yevarume nevakadzi veUnited States vane HSD3B1 (1245C) geni-kubva kune vamwe kana vabereki vose.
Nokuti ikozvino, hakusi kuedza kwakajeka kuiziva iyo (kunyange inogona kuonekwa muzere hwakazara genetic panel). Kutsvakurudza kwakawanda kunodiwa pamberi peHSD3B1 (1245C) -basi yeropa rekuedzwa rinowanikwa zvakanyanya.
Sei usingaiti zvino? Nokuti hapana humwe humwe huchapupu hwakakwana hwokuti kuchinja kurapwa kwevarume vane maitiro akasiyana-siyana kwaizovandudza zvabuda.
Tiri kuita tsvakurudzo yakawanda iye zvino kuti tione kana mamwe maitiro emishonga ehurmone achishanda zviri nani kudarika ADT mune varume ava. Kana vachidaro, tichava nehumwe uchapupu hwokuti kuongororwa kweropa kwakajeka kunofanira kuendeswa kuvharo yeHSD3B1 (1245C).
Personalized Treatment Inogona Kubudirira Kupfuura
Nhasi tinobata varwere vose vane kenza yenguva yakazara yeprostate maererano nehutano hwakanaka hwekutarisira. Asi kutsvakurudza kungave kuri kutitadzisa kuenda kune maitiro ekurapa anobva mumararamiro emarwere.
Mune ramangwana risati riri-kure-kure, tinotarisira kushandisa kuongorora mazita ekurapa kuti tione kuti varwere vanoda kupi kurapwa, panzvimbo yekurapa munhu wese zvakafanana.
Somuenzaniso, varwere vasina HSD3B1 (1245C) geni rinogona kufamba zvakanaka ne ADT. Vaya vane mairi vangada kurapwa zvakanyanya.
Dr. Sharifi ndiye wezvokurapa oncologist kuCleveland Clinic yeTaussig Cancer Institute uye anobata Sachigaro weKendrick Family Endowed kuProstate Cancer Research kuCleveland Clinic.
> Sources:
> Hearn JW, Abuali G, Reichard CA, et al. HSD3B1 uye kurwisana ne androgen-kubviswa kwehutano mukenza yeprostate: a retrospective, multicohort kudzidza. Lancet Oncol. 2016; 17 (10): 1435-1444.