Mu hypothyroidism, chirwere chetachiona chinokundikana kubereka zvakakwana chetachiona hormone thyroxine (inonziwo T4). Nokuti T4 inokosha zvakanyanya pakuraira muviri wemagetsi, kushandiswa kwekudya, kushanda kwemasumbu, uye kushanda kwepfungwa , hypothyroidism inogara iri dambudziko guru.
Utachiona gland pachahwo hunotungamirirwa nehomoni TSH (utachiona hunokurudzira hormone).
Kana chirwere chetachiona chisina kubudisa zvakakwana T4, mazinga eTSH anowedzera kuitira kuti utachiona hushande zvakaoma. Muna hypothyroidism-umo utachiona husingakwanisi kuita T4 yakakwana-mazinga eTSH anowanzotonyanya kukwirira zvikuru.
Subclinical hypothyroidism ndiyo mamiriro ekuti T4 maitiro anoramba ari munharaunda yakarongeka (kureva kuti, frank hypothyroidism haisipo), asi TSH mazinga akasimudzirwa: marefu TSH mazinga anodiwa kuitira kuti urambe uine t4 yepamusoro. Nokudaro subclinical hypothyroidism inoreva kuti utachiona gland pachahwo hahushandi zvachose. Kunongova "kuputika" chirwere chetachiona (nepamusoro maTSH mazinga) kuti mazinga T4 akakwana anogona kuchengetedzwa.
Pano pane mhirizhonga nhasi nhasi pamusoro pezvakakosha zve subclinical hypothyroidism. Nemhaka yekuti mazinga eT4 ari chaiwo akazara mumamiriro ezvinhu aya, muchirevo, subclinical hypothyroidism haifaniri kunge iri dambudziko guru.
Asi humwe uchapupu hunoratidza kuti subclinical hypothyroidism inounza zvinetso zvemakiriniki dzimwe nguva dzimwe nguva-uye, pane dzimwe nguva, inofanira kurapwa.
Pamwe chinonyanya kunetseka ne subclinical hypothyroidism ndechokuti inogona kuchinja mwoyo.
Sei Subclinical Hypothyroidism Inozivikanwa
Ichi chiitiko chinoratidzwa kuti ine kuongorora ropa, kunyanya, nekuyera mazinga eT4 nemazinga eTSH.
Subclinical hypothyroidism iripo kana mazinga eT4 ari munharaunda yakakwana (0.8 kusvika 1.8 ng / L), uye mazinga eTSH ari pamusoro pehuwandu hwemhando (0.3 kusvika 3.04 mU / L). Zvisinei, nyanzvi dzakawanda dzinofunga kuti subclinical hypothyroidism "inokosha" chete kana mazinga eTSH akakura zvikuru: kupfuura 10 mU / L.
Zvinokonzera
Zvinotendwa kuti subclinical hypothyroidism inongova chimiro chinyoro, kana chimiro chekutanga, chekusawirirana kunowanzobudisa frank hypothyroidism-kunyanya autoimmune thyroiditis ( Hashimoto's thyroiditis ). Zvechokwadi, nokufamba kwenguva, vakawanda sehafu yevanhu vane subclinical hypothyroidism vacharamba vachikudziridza frank hypothyroidism, ine tsika dzeT4 dziri pasi uye zviratidzo zvose zvinowirirana nayo . Saka, chimwe chikonzero vamwe vanachiremba vanobata subclinical hypothyroidism ndekudzivirira kuguma kwekupedzisira kwehuwandu hwakaoma zvikuru hwechokwadi chechokwadi hypothyroidism.
Zvichida Zviratidzo?
Kunyange zvazvo chiitiko ichi sezviri pachena hachiiti zviratidzo kuvanhu vakawanda, vamwe vanobvuma zviratidzo zvinyoro zvinoratidzira hypothyroidism, zvakadai sekudzivirira, kuneta, kana kusanzwisiswa kunorema. Zvinonziwo vanhu vane subclinical hypothyroidism vanogona kunge vane huwandu hwakanyanya hwekuzvidya mwoyo, kuora mwoyo, kana kukanganisika kwepfungwa.
Iyo Inobata Sei Mwoyo
Kunze kwengozi yekupedzisira kuumba frank hypothyroidism, mukuru wekutambudzika ne subclinical hypothyroidism ndeyokuti inobatanidzwa nehuwandu hwehutano hwehutano hwehutano.
Tsvakurudzo dzinoverengeka dzave zvino dzakaratidza kushamwaridzana pakati pepamusoro maTSH mazinga (makuru kupfuura 10 mU / L) uye nekuvandudzwa kwegononary artery disease (CAD) . Mukutsvakurudza kwakafuridzirwa kwezvidzidzo zvezvipatara zvakawanda zvinosanganisira vanopfuura 25 000 varwere, subclinical hypothyroidism yaibatanidza nekuwedzera kwekurwa kwemoyo, chiratidzo cheCAD, uye kufa kwemoyo. Imwe nyanzvi yekuongorora yakawana njodzi yakanyanya kuwedzera yekusakatika kwemwoyo kune varwere vane subclinical hypothyroidism.
Uye zvidzidzo zvakasiyana-siyana zvakabatanidza subclinical hypothyroidism uye yakawedzera cholesterol mazinga.
Kunyange zvazvo kushamwaridzana hakuratidzi kukonzera-uye-kushanda, zvinoonekwa kuti overtropothyroidism zvechokwadi inobereka chirwere chepfungwa chikuru. Izvi zvinopa chivimbo kune pfungwa yokuti subclinical hypothyroidism inogonawo kukanganisa mwoyo. Kuwedzera kwepfungwa dzomukati kunowanikwa ne subclinical hypothyroidism ndiyo chokwadi chinonyanya kunetseka chechiitiko ichi.
Inofanirwa Kuendeswa Kumagadzirirwo Hypothyroidism Anofanira Kuitwa Here?
Subclinical hypothyroidism inogona kurapwa nekupa utachiona hwemapiriniti kuchinja mushonga. Kurapa kunotungamirirwa nekucherechedza zvakanyatsokawanda mazinga eropa; hutoni yakakwana yakakwana yakapiwa kuderedza TSH mizinga kudzokera kune yakarongeka.
Pane humwe humwe uchapupu huripo kubva kuchikoro chekuchipatara uko kurapa subclinical hypothyroidism kunovandudza zviratidzo. Mune zvidzidzo zvinoratidza kuti inoderedza zviratidzo, iyo inobatsira inoyera inowanikwa zvishoma kune ivavo varwere avo vanotangira TSH mazinga ari akakwirira (kureva, kupfuura 10 mU / L).
Saizvozvowo, humwe uchapupu hwokuti kubata subclinical hypothyroidism kunoderedza dambudziko rehutano hwemwoyo uyewo zvishoma. Mune chidzidzo chakaitwa muGreat Britain, pakati pevarwere vaduku (vasati vava nemakore makumi manomwe) ne subclinical hypothyroidism, njodzi yehutachiona hwepfungwa yakatevera yakanyanya kuderera kune varwere vakagamuchira utachiona hweHermone therapy. Hapana rubatsiro rwekurapa rwakaratidzwa kuvakuru vakwegura vane subclinical hypothyroidism.
Uyezve, kurapa subclinical hypothyroidism kunowedzera huwandu hwehutano hwehutano hwehutano, hunosanganisira cholesterol mazinga, CRP levels , uye vascular function.
The Bottom Line
Nyanzvi dzakawanda dzinokurudzira kuporesa subclinical hypothyroidism kana TSH mazinga akakura kudarika 10 mU / L, ingave kana kwete zviratidzo zviripo.
Pasinei kuti subclinical hypothyroidism inofanirwa kurapwa kana TSH mazinga ari pasi pe 10 mU / L inoramba ichikakavadzana. Vanachiremba vazhinji vanokurudzira kurapwa kunyange mumharaunda iyi yakaderera kana varwere vane zviratidzo zvinoratidza kufungidzirwa kwe hypothyroidism, kana kuti vakawedzera cholesterol maitiro kana zvimwe zvipingamupinyi zvechirwere chepfungwa.
Unofanira Kuedzwa Here?
Mumazuva ekare (makore ane gumi kana maviri apfuura), kuongorora kwehutachiona hwebasa kwaive chikamu chechirongwa chekurapa. Asi mune zvinodiwa mari yekuchengetedza mari, kazhinji haisisiri tsika.
Zvinonzwisisika kubvunza chiremba wako kuti awane chirwere chehutachiona cheropa kana iwe une zviratidzo zvinokurudzira hypothyroidism (ona pamusoro apa), kana iwe wakasimudzira cholesterol mazinga, kana iwe unongoda kuve nechokwadi kuti uri kuita zvose zvaunogona kuderedza moyo wako .
Sources:
Rodondi N, den Elzen WP, Bauer DC, et al. Subclinical hypothyroidism uye mukana wekushaya chirwere chemwoyo uye kufa. JAMA 2010; 304: 1365.
Genre B, Collet TH, Virgini V, et al. Subclinical thyroid kusagadzikana uye njodzi yekushaya mwoyo kuitika zviitiko: mumwe munhu akabatanidza dhiyabhorosi kudonhora kubva 6 vanotarisira mazano. Circulation 2012; 126: 1040.
Razvi S, Weaver JU, Butler TJ, Pearce SH. Levothyroxine Kuchengetedzwa kweAcclinical Hypothyroidism, Kurwara uye Kusagadzikana Kwezvirwere Zvemwoyo, uye Kufa. Arch Intern Med 2012.