Epithelial Ovarian Cancer, Germ Cell, uye Sex-Cord Stromal Tumor Markers
Sezvo chirwere chekenza chechirwere chemaawa, iwe unogona kunge uchimhanya kune izwi rokuti "tumor markers." Asi izvi zvinorevei?
Kenza yeOvarian inotumidzwa nokuti yakabva kune ovary (kana kuti fallopian tubes iri pedo ne ovary.) Asi pane zvakawanda zvakasiyana-siyana zvemasero mumapapiro mavari , uye rimwe nerimwe remasero aya rinogona kuva kenza. Aya masero ese ane mabasa akasiyana uye anogadzira zvinhu zvakasiyana-siyana zvehupenyu.
Zvinhu izvi zvinogona kuyerwa muropa uye zvinonzi tumor markers.
Sei Chiremba Wako Achimhanya Chirwere Chiratidzo Chekupa Ropa
Mune zvimwe zviitiko, chirwere chinonzi tumoror is a substance that is produced only by cell cells. Zvisinei, mumatambudziko mazhinji, izvi zviratidzo zvinongoburitswa mumasikirwo asina kufanana sezvo masero anokonzera kenza anokonzera zvikamu zvakasiyana-siyana zvemichina yavo yezvinyorwa. Vanachiremba vanotaura nezvemakumbo anowedzera huwandu hwezvinhu izvi sezviremara izvo taura izvi zviratidzo. Somuenzaniso, pane kutaura kuti kenza yemaawa inokonzera zvinokonzerwa zvakanyanya zveCA-125, vangareva kuti kenza inoratidza CA-125 .
Marudzi eOvarian Cancers
Mune zvimwe zviitiko, izvi zvinoreva kuti chiremba wako anogona kutarisa ropa rako kuti uedze zvirwere zvinorapa, zvichiratidza rudzi rwekenza iripo, kana kuti gare gare, kuti mushonga wako unoshanda zvakadini. Kazhinji, zvipembenene zvinoderera kana chirwere ichibudirira.
Kenza yakawanda inowanzoitwa kanonzi ovary inonzi kanzvadzi epithelial ovarian. Pane matatu subtypes: mucinous, serous uye endometrioid. Mhando dzinowanikwa dzisina kuwanda dzekenza yevana mavari dzinonzi germ cell uye chirwere chepabonde chinokonzerwa nekenza. Chimwe nechimwe chezvinhu izvi chine mazita mashoma, asi zviratidzo zvakafanana kune imwe neimwe yezvikamu zvakakura.
Epithelial Ovarian Cancer Tumor Markers
Iko-CA-125 tumor marker ropa test ndiyo inowanzozivikanwa inoshandiswa neboka iri rekenza. CA inomirira "cancer antigen." CA-125 inogona kugadzirwa nemasero akajairika asi inogadzirwa mune zvakanyanya kukanganiswa mune mamwe masero ekenza yevarivha kupfuura masero evanhu vanowanzobuda.
CA-125 inogona kushandiswa sechikamu chehupenyu hwehutachiona hwehutachiona kuti uongorore kenza yemaawa, kana inogona kushandiswa kuongorora kupindura kune maitiro ekurapa mahara. Haasi mahara evanhu vose vanoratidzira CA-125, uye mazinga akajairika mumapoteredza 20% emhando iyi yekenza yevana. Kusiyana neizvi, zvimwe zvipembenene zvinokonzera mavari, pamwe chete nedzimwe mamiriro ezvinhu, zvinogona kuguma neA-CA yakakwirira yepamusoro.
Pamusoro pe 3 subtypes yemukenza epithelial ovarian, kanzvadzi mucinous haigoni kuratidza CA-125 kupfuura mishonga inonzi serous kana endometrioid.
HE4 - vanhu epididymis protein 4 inoratidzika mutsva inoratidzika zvakare inogona kuratidzwa mukenza yevana, uye seC CA-125 inowanzowanika nemaronda e serous uye endometrioid. Vamwe vatsvakurudzi vakaona kuti kushandiswa kweA-125 ne HE4 kunobatsira pakuongorora kenza yemavhizha pane imwe yero inoshandiswa yoga.
Sezvo vakadzi vari pasi pemakore makumi mana vane mikana yakawanda yekuve neye mucinous subtype yekenza epithelial ovarian, idzi 2 zvipembenene zvingave zvisingabatsiri mukugadzirisa chirongwa chevakadzi vaduku.
Zvimwe zvirwere zvinokonzera maronda izvo dzimwe nguva zvinogona kubatsira pakuchengeta kanzvadzi mucinous ovarian CA-72-4, CA-19-9 uye CEA (carcinoembryonic antigen). Iko kune zvimwe zvingave zvakasimudzwa asi zvisinganyanyi kushandiswa. CA 19-9 inowanzowanikwa kune vakadzi vane mucinous subtype uye inogona kubatsira mukugadzirisa chirongwa ichi pamwe chete neA CA-125.
Germ-Cell Tumor Markers
Zviratidzo zviviri zvakashandiswa zveboka iri rekenza ndezvi: alpha-feto protein (AFP) uye chorionic gonadotropin (hCG) yevanhu . Iyo yekupedzisira inoshandiswawo kutarisa kubata pamuviri. Nhamba dze AFP neHCG dzakakosha zvikuru inzira yakanyatsonaka yekuongorora zvirwere izvi.
Zvepabonde-tambo Inonzi Stromal Tumor Markers
Izvo chete zviratidzo mune izvi zvinobatsira zvinobudiswa ne granulosa cell subtype. Izvi zvinosanganisira estradiol (chiratidzo che estrogen) uye inhibin . Sezvo izvi zvipembenene zvinowanzowanikwa kuvasikana vaduku , izvi zvinogona kuitwa sechikamu chekubata kwemuviri mashoma (uye zvimwe zviratidzo zvakadai sokupererwa kwepakutanga) muvasikana nevasikana vaduku.
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