Matethesi akawanikwa kunge asina kunyatsoshanda kurapwa
Pamusangano wa2017 weAmerican Thyroid Association, vatsvakurudzi vanoverengeka vakataura nezvekutsvakurudza kwetsva kwakaratidza kuti mafuta evevothyroxine anoshanda zvakanyanya kupfuura mahwendefa mukurapa mapoka akawanda evarwere.
Levothyroxine iyo inogadzirwa nemishonga ye thyroxine (T4), hormone inokonzerwa nehutachiona. Levothyroxine ndiyo inonyanya kurapwa kwe hypothyroidism, utachiona husingagadziriswi hunowanzowanzokonzerwa nokuvhiya kubviswa kwetachiona, kushandiswa kwemhepo inoshandiswa kwemhepo, uye kuparadza gland nemhaka yehutachiona hweHimmoto's thyroiditis.
Generic levothyroxine, uye kazhinji-anozivikanwa mazita emakiti akafanana neSythroid neLevoxyl, ndiwo mapepa ehutachiona ehistori inoshandiswa mushonga . Ipepeti ye levothyroxine ndiyo nzira inonyanya kushandisa iyi mushonga inotorwa.
Kwemakore anoverengeka, mvura, softgel capsule fomu ye levothyroxine yave iripo muUnited States pasi pezita rinonzi Tirosint . ITirosint brand ye levothyroxine yakagadzirirwa zvikuru seye hypoallergenic, maitiro chaiwo evevothyroxine kune vanhu vane chirwere chekudya kana mumatumbo, zvinetso nekunwa kwemishonga yekemikari, kana kushaya mishonga kune vakazadza uye vanobatanidza mu tablet ye formvroroxine zvinodhaka.
MunaFebruary ra2017, FDA yakabvumira mvura yev levothyroxine, Tirosint-SOL. Liquid levothyroxine yave iripo kuItaly kubvira muna 2012. Iwairothyroxine yakasvibiswa yakaitwa seimwe nzira kune varwere vasingakwanisi kumedza, avo vanodyiwa ne tube, uye nevana vane hypothyroidism.
Tirosint-SOL inotarisirwa kuwanikwa mumusika weAmerica muna 2018.
Mutova Levothyroxine vs. Matetet
Mune rumwe ruzivo, vaongorori veItaly vakaratidza kuti mafuta evevothyroxine anoguma nekugadzirisa zviri nani kwehutachiona hunoenzaniswa nemapiritsi. Vakatarisa boka revarwere vachitora mapiritsi e-levothyroxine, avo, pasinei nehotera inowedzera, vakanga vasina utachiona hunokurudzira hormone (TSH) uye mahwindo eT4 akasununguka mukati mezera rekutarisa.
Vatsvakurudzi vakashandura varwere vachienda kune imwechete yemvura kana softgel levothyroxine uye vakadzorerazve utachiona hwavo. Vakaona kuti 85 kubva muzana yevarwere vakadzidza vakaratidza kuwedzera kukuru mune zvose maTSH avo uye mazinga avo asina T4. Mavhiki mashomanana mushure mokutanga marangi e-levothyroxine, varwere ve hypothyroid vakakwanisa kusvika kuhutachiona mukati mezvakatarisirwa zvikamu.
Vatsvakurudzi vakagumisa kuti mvura yakasvibiswa yev levothyroxine ine mhinduro inofadza zvikuru kana ichifananidzwa nehwendefa inogadzirwa mune vamwe varwere.
Pashure peTyroidectomy, Softgel Capsules Zvimwe Zvinobudirira
Mune imwe dzidzo, vatsvakurudzi vakafananidza kubudirira kwemapiritsi e levothyroxine uye softgels kune varwere vaiva nehutachiona hwehutachiona hwema multinodular goiter. Ava varwere vakanga vasina matambudziko ekurapa.
Inenge hafu yevadzidzi vaidzidza vakapiwa mahwendefa, uye imwe hafu yakagamuchira softgel capsules pane chirwere chimwe chete, kutanga pakarepo mushure mekuvhiyiwa kwehutano. Varwere veTSH, vakasununguka thyroxine (FT4), uye mahwindo ehurukuro e-triiodothyronine (FT3) akaongororwa mushure memavhiki matanhatu uye pashure pemasvondo gumi nemaviri.
Pamasvondo matanhatu nemasvondo gumi nemaviri, varwere vachitora softgel capsules vainge vashoma kwazvo mazinga eTSH.
Panyaya mbiri dzekuyera, nhamba yevarwere vakange vakwiridza mazinga eTSH ari pamusoro pe 3.5 mcU / ml-inonzi hypothyroid yekudzidza uku-yakanyanya kukura kune varwere vanogamuchira mahwendefa. Vatsvakurudzi vakagumisa kuti kunyange kune varwere vakanga vasina zvirwere zvema malagorption kana kudya, levothyroxine softgel capsules yakanga iri yakanyanya.
Zviri nani TSH Kudzora TSH Mushure meKenza
Chimwe chidzidzo cheItaly chakatarisa varwere vakasiyana-siyana nekenza yekenza (DTC) kutora levothyroxine. Maererano neAmerican Thyroid Association, varwere ava vanofanira kuisa TSH yepamusoro pakati pe1 ne1,5 mU / L-pasi pemucheto wezasi wekutarisa--kubatsira kudzivirira kudzokorora kwekenza yekroid.
Nokuti iyi ihwindo rakamanikana, zvakakosha kuti kurapa kwevavothyroxine igare yakasimba pakuchengetedza TSH.
Vatsvakurudzi vanofananidza nekusiyana kwehutano hweTSH kune varwere vanobatwa ne liquid levothyroxine, maererano nemapiritsi. Hafu yevarwere yakagamuchira yeavi levothyroxine, uye hafu yakagamuchira piritsi, uye vose vakange vane utachiona hwakafanana hwehutoni hwekuwedzerwa. Zvimwe zviyero zveTSH mazinga zvakaitwa.
Vatsvakurudzi vakaona kuwedzera kukuru kwemazinga eTSH muvarwere vachitora mapiritsi, vachienzaniswa nevaya vanotora liquid levothyroxine. Kunyanya, inenge 16 kubva muzana yevarwere pamapiritsi haana kusvika kune chinangwa cheTSH chikafu, achienzaniswa ne4% chete yeavo inonzi liquid levothyroxine. Vatsvakurudzi vakagumisa kuti kushandiswa kweL LT4 levothyroxine kwakaenzaniswa nemapiritsi kwakaguma nenhamba yakakura zvikuru yevanorwara nekenza vanochengeta TSH maonero ayo anotarisirwa kuita kuti vaderedze ngozi yavo yekudzoka kwekenza.
Pamusoro peRoidid Levothyroxine
Sezvakataurwa, muU.S., kutengeswa kwemafuta emhepo levothyroxine inowanikwa muTirosint brand softgel capsules, uye muTirosint-SOL mvura. Tirosint haina shuga, dyes, doro, gorosi starch (gluten), lactose, acacia , kana zvimwe zvimwe zvinowanikwa kana zvinogadzirwa zvinowanzoshandiswa kuita mapiritsi e levothyroxine. Izvo chete zvinoshandiswa mu capsules ndeye levothyroxine, gelatin, glycerin, uye mvura, izvo zvisingakwanisi kupindira nekudya kana kuti kukonzera kurwara. ITirosint-SOL ine chete levothyroxine.
Tirosint yakachengetedzwa zvikuru kuvarwere vane mamiriro akafanana neCrohn's disease kana kuti chinoshungurudza chirwere chemawere chinonzi chinoita kuti chigadzire kudya kana kupindira. Nemhaka yokuti iyo hypoallergenic, inoshandiswawo nevarwere vane mishonga inogamuchirwa kusvika kune zvinogadzirwa kana zvishandiso zvinoshandiswa mukugadzirwa kwezita rezita uye mapiritsi e generic levothyroxine.
Vamwe vakawedzera kubatsirwa kweTirosint mvura maitiro: zvokudya, calcium , iron, kofi , uye mukaka hazviiti sekuti zvinopesana nekunwa kwevhesi levothyroxine, sezvavanoita nemapiritsi.
Nemhaka yehuwandu hwehuwandu hwehutachiona hwehutachiona hwevanhu vashoma, uye nokuti Tirosint inodhura zvakanyanya kudarika mamwe mabhuku eLevothyroxine kana mahwendefa akawandisa, inofanirwa kushandiswa haisati yakashandiswa zvikuru kune hypothyroidism kurapwa muUnited States.
Shoko Rinobva
Tsvakurudzo dzinowanikwa dzinoratidza kuti varwere vazhinji-kwete avo avo vane malabsorption kana kuora- vanogona kubatsirwa nekutsauka kubva pamapiritsi evevothyroxine kusvika kune mamwe marudzi eLevothyroxine. Imwe tsvakurudzo yakatsvakurudzwa yakabudiswa mumagazini inonzi RD Diet yakawana kuti pakati pe1000 varwere vanotora levothyroxine, 15 muzana vakanga vane mishonga yepamusoro kune zvinyorwa uye zvimwe zvinowanikwa mumaphilitsi e levothyroxine.
Pane zvimwe zvinetso zvekuita shanduko kubva pa tablet tablet levothyroxine kusvika kuTirosint softgel capsules kana Tirosint-SOL mvura, zvisinei:
- Chiremba wako angasaziva nezveTirosint capsules kana Tirosint-SOL mvura sezvasarudzo.
- Inishuwarenzi yako, HMO, kana humwe hutano hwehutano hungave huchida kubhadhara kana kubhadhara zveTirosint. Muchiitiko ichi, unogona kudikanwa nehutano hwehutano hwako kuti uite "kuparadzanisa sezvakanyorwa" kana kuti "kusashandura / kwete" generic "mishonga.
- Kana iwe uchifanira kubhadhara kunze kwehomwe, kutengesa mari-iyo inogona kunge yakaita $ 50 kusvika $ 100 kana kupfuura pamwedzi-inogona kuita kuti shanduro isakanganise iwe mari.
Kana, zvakadaro, iwe uri kuwana zvakaoma kuti uwane maitiro ako akaenzana kana kuti akakodzera kuongororwa kwetroroid uye usarudze kupfuurira kwako zviratidzo zve hypothyroidism, iwe ungada kuva nehurukuro nemutarisiri wako wehutano pamusoro pekuti kana kuchinja mumushonga wako kunorudzirwa.
> Sources:
> Benvanga, S. et al. "L-Thyroxine muOral Liquid kana Softgel Formulation Inoita Kuti Seruum Yakawanda Yakasununguka yeT4 yakasununguka." Utachiona. October 2017, 27 (S1): A-166-A-188.
> Fallahi, P et. al. "Mharidzo L-Thyroxine muGel Capsule Versus The Tablet Formulation in Patient Inotumirwa Kuwandisa Kwako Utachiona." Utachiona. October 2017, 27 (S1): A-166-A-188.
> McMillan M, Rotenberg K, et al. Cormorbidities, Mishonga inogadziriswa, uye kudya kunoita zvinhu zvinokonzera levothyroxine therapy: migumisiro ye CONTROL kuongorora chirongwa. Zvinodhaka RD. 2015. December 21.
> Pirola, I. et. al. "TSH Kusiyana Kwevarwere Vanoparadzaniswa neKenza Yekenza Yekare Yakasiyana Nee Levothyroxine Liquid Solution kana Tablet." Utachiona. October 2017, 27 (S1): A-166-A-188.
> Sevilla Alsina, ME et. al. "Nzira Isinganzwisisiki Mukutungamirirwa kweHypothyroidism Mushure mekusakundikana kweMuromo weLevothyroxine." Utachiona. October 2017, 27 (S1): A-166-A-188.