Mercaptopurine (Purinethol, 6-MP) Nzira Dzakashata

Bvunza Daktari Wako Nezvipingamupinyi Zvakaipa Kare, Nguva, uye Pashure Pokutora Iyi Dhiragi

Mercaptopurine mishonga inonzi inozivikanwa seine purine. Inoshandiswa mumamiriro ekurapa akadai seCrohn's disease uye ulcerative colitis (maitiro maviri ekuputika kwechirwere chirwere [IBD] ) uye acute lymphocytic leukemia. Inogona kushandiswa pakurapa kweimwe mamiriro ezvinhu zvakare.

6-mercaptopurine (6-MP) inowanzoitwa kamwe chete pazuva, uye inogona kupiwa kana iri muhwendefa kana mujinga.

Zvinhu Zvinonyanya Kukosha Kuziva Nezve 6-MP

Mashoko Akakosha Pamusoro pe 6-MP

Zvinhu zvinonyanya kukosha kuziva pamusoro pe 6-MP ndezvokuti zvinogona kukonzera zvimwe zvinokonzera, zvakadai sekushaiwa bvudzi, kurutsira, chirwere, nekuda kurasikirwa. Izvo hazvifaniriwo kushandiswa mukati memavhiki maviri ekugamuchira chirwere chinorarama. Kana usina chokwadi kana chirwere chawakagamuchira chakararama, tarisa nechiremba wako.

Kusuruvara kwebvudzi kunogona kuva kunetseka zvikuru, asi kunofanira kuchinja apo mishonga inomira, uye bvudzi richatanga kukura zvakare kazhinji. Chimwe chidzidzo chakaratidza kuti 1% yevanhu vanotora 6-MP kuti vararame IBD yakarasikirwa nevhudzi.

Zvimwe zvakajairika zvakanga zvakaderedzwa tsvuku reyero yeropa , iyo yakawanikwa mune inenge 11 muzana yevarwere.

Nekukurumidza kunetseka kune migumisiro yakaipa yakadai sekubuda ropa, kupwanya, kana maronda; chizungu kana kurasikirwa kwekuziva; muromo wemuromo; uye marwadzo akabatanidzwa. Zvimwe zveizvi zvinogonawo kuitika sezviratidzo zveBD, saka zvakakosha kuchengetedza chiremba wako muchidimbu pamatambudziko ose ari kuitika.

6-MP inogonawo kukonzera kushaya muviri kusinganzwisisi, uye mune imwe chidzidzo, izvi zvakaitika munenge 4% yevarwere vanoitora kuti vabate IBD. Nokuda kwechikonzero ichi, chiremba angada kuita nguva yekuongororwa kweropa kutevera chiropa basa. Mune zvimwe zviitiko, kukwirira kwezvinhu zvimwe muropa (aminotransferases) kunogona kureva kuti muyero wechirwere unoda kuderedzwa, kana kuti unoda kubviswa.

Zvinokurudzirwa kuti vakadzi vashandise kubata pamuviri vachitora 6-MP kuti vasapinda pamuviri. 6-MP ndeye FDA Chikwata Chekuberekwa D: panogona kunge kune ngozi kune fetus, asi mishonga inogona kuenderera mberi nokuti kuidzika kunogona kuva nemigumisiro yakaipa kune amai. Kana iwe ukava nepamuviri paunotora 6-MP, udza chiremba wako. Kuberesa mwana paanotora 6-MP hakurudzirwi.

Muchikamu Chisingabatanidzi Maitiro Akafanana 6-MP

Tarisa nechiremba wako kana chimwe chezvikamu zvinotevera zvinopfuurira kana zvinotambudza:

Nguva Zese Zivisai Dhigiri WeZvibato Zakawanda

Zvimwe zvakajairika

Zvishoma Zvisingatauriki

Kazhinji

Zivisai A Chiremba Pakarepo Pamusoro Pemamwe Matambudziko Acho

Zvisiri zvishoma

Zvimwe Zvikamu Zvinokosha

Nemhaka yemishonga inoshanda mumutumbi, kune mukana wekuti ingakonzera zvimwe zvinenge zvisingadikanwi nemwedzi kana makore mushure mekunge mushonga usingashandiswa. Izvi zvinononoka migumisiro inogona kusanganisira mamwe marudzi ekenza iyo inofanira kukurukurwa nachiremba.

Mercaptopurine inogona kugadzirisa migumisiro mushure mokurega kurapwa. Panguva iyi nguva, tarisa nechiremba kana chimwe chezviitiko zvinotevera zvichiitika:

Dzimwe mimwe migumisiro isina kunyorwa pamusoro apa inogonawo kuitika pane vamwe varwere. Kana ukacherechedza zvimwe zviitiko, tarisa nechiremba wako. Iyi ruzivo inongororwa semutungamiri - nguva dzose uongorore chiremba kana mhizimisi kuti uwane ruzivo rwakakwana pamusoro pemishonga yekurapa.

Kunobva:

Glazier KD, Palance AL, Griffel LH, Das KM. "Chiitiko chemakore gumi chisina kuroorwa-chinonzi 6-mercaptopurine mukurapa kwechirwere chechirwere chirwere." J Clinic Gastroenterol . 2005 Jan; 39: 21-26.

Mahadevan U. "Kubereka nekuzvitakura mumurwere ane chirwere chinoputika." Gut . 2006 Aug; 55: 1198-1206.

Shaye OA, Yadegari M, Abreu MT, et al. "Hepatotoxicity ye 6-mercaptopurine (6-MP) uye Azathioprine (AZA) muvanhu vakuru vechiBD." Am J Gastroenterol . 2007 Nov; 102: 2488-2494.