Hormone therapy inorayirwa nechiremba oncologist yevakadzi uye varume vanorwara nekenza yemapirmone receptor-positive. Inorayirwa kunonoka kana kumisa kukura kwemakumbo ehommone-kutadza kuburikidza nekudzivirira simba remuviri yekubudisa mahomoni kana kupindira nemaitiro ehomoni. Apo inotorwa nevakadzi nevarume vane mazamu emucheto-kutanga, inobatsira kuderedza ngozi yekuwana kudzokorora kwekenza yepamupi yepabonde kana kuwana kenza itsva yepamuti yepamuviri.
Zvichikosha kukosha kwemaawa ekurapa, kubatsira vakadzi nevarume kugadzirisa migumisiro yehutachiona hweHormone inokosha kuti varambe varipo kune yakatarwa makore mashanu kana kupfuura.
Hormone Therapy Mishonga
Tamoxifen imishonga inoshandiswa kurapa chirwere cheE ER-positive munguva yepakutanga chepamuviri muvakadzi vepremenopausal uye postmenopausal pamwe chete nevarume. Tamoxifen inogamuchirwa neCDA uye yakashandiswa zvakanyanya kwemakore anodarika makumi matatu.
Aromatase Inhibitors (AIs) ikirasi yemishonga inoshandiswa mukurapa kenza yemazamu mumadzimai emu postopaopausal uye gynecomastia mumarume. Dzinosanganisira Anastrozole (Arimidex), Letrozole (Femara), Exemestane (Aromasin), Goserelin (Zoladex).
Tamoxifen uye Arimidex ndiyo mishonga yemishonga inonzi hormone inowanzotarisirwa kune varwere vane chirwere chekutanga chema-hormone receptor-positive mushure mokupera kwekushanda kwavo.
Migumisiro Yechiri
Mimwe mishonga yemishonga inonzi hormone ine madhara kusvika pamwero miviri, asi vamwe vane migumisiro inobatsira pamusana wehupenyu hwehupenyu.
Kutambudzika kwepfupa uye pamwe chete, iyo inonyunyuta yevakawanda inotora chirwere cheHormone, inopindira iyo iyo inokonzera matambudziko muupenyu hwezuva nezuva.
Tichifunga kuti iyo hormone therapy inowanzotarisirwa kwemakore mashanu uye zvichida kwenguva yakareba, kutsvaga nzira dzekudzikisa kukanganisa kwepfupa uye marwadzo ekubatana, kufamba-basa, uye mabasa ezviitiko zvehupenyu hwezuva nezuva inonyanya kunetseka.
Apo vakadzi nevarume vane chirwere chemahomoni havakwanise kuwana zororo kubva pamapfupa avo uye majoka, vakawanda vanofunga kubvisa kurapwa, uye vamwe vanoita. Tamoxifen uye Arimidex, iyo aromatase inhibitor yekusarudza kwekutanga kwekutanga, hormone-receptor-positive chenza chepamu, zvose zviri zviviri zvinozivikanwa kuti zvinokanganiswa nemigumisiro yakadaro inosanganisira:
Kupisa kunopisa uye usiku hukutuka
Kurasikirwa kwepabonde motokari
Vaginal discharge
Vaginal yakaoma kana kuchenesa
Kuwedzera kwehuwandu
Kurara zvinetso
Mood inoshanduka
Muzviitiko zvisingawanzoitiki, Tamoxifen yakambotaurwa kuti inokonzera ropa, mapfupa emapfupa mumadzimai e-foremenopausal, kenza yemapendometrial, cataracts, uye chirwere.
Iko Tamoxifen kana Arimidex Inonyanya Kubudirira Here?
Arimidex, Tamoxifen, Alone kana muMusanganiswa (ATAC) Kuedzwa kwakaenzanisa kubatsirwa uye kuchengeteka kweArimidx (1 mg) neTamoxifen (20 mg) , inopiwa muromo zuva rimwe nerimwe kwemakore mashanu, sekurapa adjuvant kuvakadzi veimenopausal vane mazamu okutanga kenza.
Arimidex yakaratidza kuti inoshanda kupfuura Tamoxifen. Arimidex inonyanya kubudirira:
- Kunyora nguva iyo pakati pekutanga kuongororwa nekudzokorora kune avo vanoona kudzokorora
- Kuderedza ngozi yechirwere chekushaya mishonga kune dzimwe nzvimbo dzomuviri
- Kuderedza dambudziko rekugadzira kenza mutsva muchigunzva chifuva
Zvisinei, kurwadziwa kwepfupa nejojo kwakaverengwa kakawanda pane Arimidex kupfuura Tamoxifen.
Kurasikirwa kwetema uye arthritis kwakaitikawo kakawanda mumakore maviri okutanga ekutora Arimidex.
Kune vakadzi vazhinji, kuitika kwezuva rimwe nerimwe kwepfupa uye marwadzo ekubatana ndiko kunyunyuta kwavo kukuru. Kuoma kwekutambudzika uku uye kukanganisa kwayo muupenyu hwezuva nezuva kunokonzera vamwe vakadzi paArimidx kuti varege kuitora.
Vazhinji vakadzi vane marwadzo emapfupa uye pamwe chete vanotaura kuti vane kuoma uye kurwadziwa, pavanomuka, mumaoko avo, mahudyu, kumashure, mabvi, tsoka, uye mapepa izvo zvaiita kuti zvive zvakaoma kuita mabasa ezuva nezuva nemabasa anobata mabasa. Nhamo dzakabatana dzinowanzoitika mumabvi, kumashure, makumbo, uye tsoka sezvo, pamwe nehudyu. Carpal tunnel syndrome yaigara iri kunyunyuta.
Vakadzi vazhinji vanotaura kuti vane unyoro kusvika kumapfupa akaenzana uye kurwadziwa pamwe chete; ivo vaikwanisa kuwana marwadzo ekurwadziwa kubva pakutora zvisiri-steroidal anti-inflammatory drugs.
Zvidzidzo zviduku zvakaratidza kuti vakadzi vanotora zvokudya zvinowedzera kudya zvinosanganisira mavitamini, glucosamine uye chondroitin, vitamini D, uye omega hove mafuta, nguva dzose vakawana ruzamuro kubva pamapfupa emapfupa uye pamwe chete. Kugadziriswa kwakaratidzawo kuti kunobatsirawo kubvisa marwadzo emapfupa. Vakadzi vanotora Arimidex kana imwe aromatase inhibitor vanokurudzirwa kugara vachiita basa rinorema.
Zvichipa kuti aromatase inhibitors inonyatsozivikanwa kuti inokonzera kurwadziwa kwemasuru uye pamwe, zvakakosha kutaurira team yako ye oncology kana iwe uchikudziridza izvi. Bhodhi rako richada kuongorora mapfupa ako uye marwadzo ekubatanidza, rinokutaurirei pfupa rekuongorora kwepfupa uye kukurudzira maitiro, mabasa, uye kushandiswa kwemishonga kuderedza marwadzo ako.
Zvigumisiro zvekudzidza zvishoma, zvakapiwa muSan Antonio Breast Cancer Symposium muna 2013, zvakaratidza kuti vakapona vaitora aromatase inhibitor vaibatanidzwa nguva dzose mumakore ekurovedza kwegore kwaive nekuderera kwe30 muzana mukurwadziwa kwavo kwakaipisisa uye kupera kwe20 muzana mumatambudziko ekurwadziwa kwavo. Izvi zvinoderedza marwadzo zvakakonzera kuwedzera kukwanisa kuita zviitiko zvekuita zvehupenyu hwezuva nezuva. Vakadzi vari muchidzidzo avo vasina kutevera chirongwa chekuita basa kwegore vakawana 5 muzana kuwedzera kwekutambudzika uye mukuoma kwemarwadzo avo.
Kutaura kubva pane zvakaitika, hutano nehutano hweArimidx, the aromatase inhibitor yakamirirwa kwandiri kutevera kamu yangu yechipiri yebonde, yakanga yakaoma kudarika kupfuura yeTamoxifen, iyo yandakatora kutevera kamu yangu yekutanga yepamu. Marwadzo anobva Arimidex akanga ari pedyo nemakumbo angu chete, uye kazhinji aigara aripo, achindimutsa kubva kurara. Yakapindirana nehuwandu hwemafirimu angu aidiwa, kufamba makiromita maviri pazuva.
Marwadzo neTamoxifen ainyanya kuparadzana mumuviri wangu wese uye akanga akafanana nemapapiro akauya uye akaenda. Chinetso chikuru cheTamoxifen chaiye chaiva musumbu mutsvuku mumhuru dzangu.
Ndakagadzirisa marwadzo kubva Arimidex uye makumbo eTamoxifen nekuita zvidzidzo zvinyoro zvezuva nezuva, kushambira 3x pavhiki, uye kuedza kufamba maira anenge zuva rimwe nerimwe. Shangu dzakasimba dzakasimbiswa nesimbi uye 1-1 / 2 inch heel yakaita musiyano mukuru mukukwanisa kwandinoita kufamba nedzimwe nyaradzo yekunyaradza. Kwete kusiyana nekurwadziwa nekuoma kweArthritis, kurwadziwa kwetsoka kwaizoguma kuderera sezvo ndakaramba ndichifamba, uye pakuguma kwekufamba kwangu, ndakanga ndisingatambudzi-pasina. Bhuku dzomugungwa rinodziya uye dzimwe nguva netsoka uye mwendo kuisa muviri kwakabatsirawo.
Shoko kubva
Hormone therapy inoshanda uye inoderedza kuitika kwekudzoka. Arimidex iri kunyorwa kakawanda kudarika Tamoxifen sezvo yakaratidza kuti yakabudirira kupfuura Tamoxifen mukudzivirira kudzokorora. Kana iwe uri kutora aromatase inhibitor uye uri kutarisana nemarwadzo emapfupa uye akabatana, igoverana zvauri kutarisana neveki yako ye oncology. Iwe unogona kukurudzirwa kuti utore chikamu mune imwe chirongwa chegadziriro yezvidzidzo munharaunda yako kana kubatana neboka rinofamba. Mushonga wako wezvenecologist anogona kukukurudzira pamusoro pemarwadzo anononoka aunogona kutora zvakachengeteka, sekunge kunyange pamusoro pemishonga yekurapa ine madhara.
> Sources:
> Cuzick J. Chiitiko che anastrozole uye tamoxifen sechirongwa cheAdjuvant chekenza yepamuvako-kutanga: kuongorora kwemakore gumi kwechikwata che ATAC. The Lancet. Oncology. 2010; 11 (12): 1135-41. http://www.ncbi.nlm.nih.gov/pubmed/21087898
> Gaillard S, Stearns V. Aromatase inhibitor-inosanganisira bone uye musculoskeletal effect: Utsva hutsva hunotsanangura etiology uye mazano ekutungamirira. Tsvakurudzo yekenza yepabonde: BCR. 2011; 13 (2). http://www.ncbi.nlm.nih.gov/pubmed/21457526