Kuderedza Zviratidzo zve Irritable Bowel Syndrome
Viberzi (eluxadoline) imishonga inogamuchirwa neU.S. Food and Drug Administration (FDA) yekurapa kwehurwere-inonyanya kukosha IBS (IBS-D) kune vanhu vakuru. Viberzi yakagadzirirwa kushanda munzvimbo yepachikafu chekudya kunobatsira kudzora mararamiro uye kuderedza marwadzo emimba anokonzerwa nechirwere.
Kunyange zvazvo vanachiremba vachiri kunyatsonzwisisa zvikonzero zvinowanzokonzera zviratidzo zveBS (kusanganisira kurwadziwa mumimba, kubvongodza, gesi, chirwere, kana kubatwa), Viberzi inokwanisa kupa ruregerero kune vanorwara vasingagamuchirwi nemagariro evanhu vanorwara.
Viberzi Inoshanda Sei
Viberzi inowanikwa nemutemo uye yakagadzirirwa kutorwa nemuromo, kaviri zuva nezuva, nechingwa. Iyo inouya mumapiritsi 75-milligiramu uye 100-milligiramu yakafukidzwa.
Viberzi inoshandisa kuburikidza kana kuvhara zvakasiyana-siyana maopioid receptors mune gumbo rekudya. Idzi ndidzo dzinogamuchirwa mumvura inoshandiswa mumvura , marwadzo ekurwadziwa, uye kuvharwa kwemukati wemvura. Viberzi yakasiyana neyekuti inokurudzira miviri miviri yekugamuchira uye inovhara mumwe, ichipa ruzivo pasina kuvhiringidzwa.
Izvi zvinogamuchirwa mumwe nomumwe ane mabasa akasiyana uye akasiyana:
- Mu receptors inokonzera gutera motility (kupesana kwemaviri emimba).
- Kappa receptors inodzivisa zvipfeko zvekoni.
- Delta receptors inobatanidzwa mumakumbo emukati.
Kuwedzerwa kwevamwe vanopikisana neve delta ndiyo inokosha yekudzivisa kuvimbiswa kunoonekwa nemimwe mishonga yakadai seImodium (loperamide) uye Lomotil (atropine / diphenoxylate) iyo inongogadzirisa mu nomu kappa receptors.
Iyo FDA inobvumira Viberzi inotarisana nezvikamu zviviri zveGirase III mimwe miedzo yakagumisa kuti mishonga yakapa kuwedzera kukurumidza muhuwandu uye kukurumidzira kwemafupa uye kuwedzera kunononoka mumarwadzo emimba uye kugadzikana kwechigaro.
Zvinodhaka Maitiro Ezvimwe
Zvimwe zvikamu zveViberzi zvinowanzoita zviratidzo mumatumbi asi zvinogonawo kukanganisa mamwe maitiro nekuda kwemigumisiro yeopioid.
Mune zvimwe zviitiko, zviratidzo zvechirwere zvinogona kukonzera ivo vakafanana ivo vakawana neBS. Pakati pezvimwe zvinowanzovhiringidza:
- Nausea
- Marwadzo emudumbu
- Kumusoro kuputika kwepamuviri tsukamu
- Kudzora
- Runny kana kuti pfumbu yakakosha
- Bloating
- Bronchitis
- Chizutu
- Gesi
- Mapundu
- Kuneta
Iopioid effect inogona, muzviitiko zvisingawanzoitiki, inokonzera sphincter yeOdidi (iyo valve iyo inotungamirira kubuda kwe bile uye pancreatic fluid mumatumbo). Kana izvi zvikaitika, kuputika kunogona kukura.
Saizvozvowo, Viberzi haigoni kurongerwa kune vanhu vasina chirwere (chironga chinobereka bile) kana kuti vane pancreatitis, kushaya simba kwechiropa, kuvhara bate, kana kuvhiringidzwa kwakasimba. Hospitali uye rufu zvakave zvichitaurirwa muvanhu vasina gorofu avo vakatora mashomanana maviri eViberzi.
Inofanirawo kudziviswa muvanhu vanonwa zvinodarika zvinodhaka zvinodhaka pazuva.
Mushonga weopioid, Viberzi ine mikana yekushandiswa nekushungurudza uye / kana kuvimba. Inofanira kungoshandiswa chete pasi pekutarisirwa kwechiremba. Kunyange zvazvo migumisiro yakanyanya kudarika yaOxycontin (oxycodone), inogona kukonzera kufanana kana yakashandiswa zvisina kunaka uye inotungamirira kuopioid kuvimba.
> Sources:
> Davenport, J .; Covington, P .; Bonifacio, L. et.al. "Migumisiro yekutakura vatengesi OAT3 uye OATP1B1 uye mutoro wemotokari MRP2 pane pharmacokinetics ye eluxadoline." J Clin Pharmacol. 2015; 55: 534-42. DOI: 10.1002 / jcph.442.
> Dove, L .; Lembo, A .; Randall, C. et.al. "Eluxadoline Zvirwere Zvirwere Zvine Irritable Bowel Syndrome Zvine Diarrhea muChikamu 2 Chidzidzo." Gastroenterology 2013; 145: 329-38. DOI: 10.1053 / j.gastro.2013.04.006.
> US Food and Drug Administration. "FDA inonyevera pamusoro pehuwandu hwehutachiwana hunokonzerwa nekuputika kwechirwere nemishonga inokanganisa Viberzi (eluxadoline) kune varwere vasina nduru." Silver Spring, Maryland; yakabudiswa muna August 2016.