Chirwere Chisingaperi Chinobata Maitiro Akawanda
Costello syndrome chirwere chisingawanzwisisiki chinokanganisa miitiro yakawanda yomuviri, zvichikonzera chimiro chiduku, chimiro chechimiro chechimiro, kukura kumativi emhino nemuromo, uye zvinetso zvemwoyo. Chinokonzera Costello syndrome hachizivikanwi, kunyange zvazvo kuchinja kwemazwi kunofungidzirwa. Muna 2005 vatsvakurudzi veDhippont Hospital yevana muDelaware (US) vakawana kuchinja kwemajini muhutano hweH HRAS vaivapo muna 82.5% yevanhu 40 vane Costello syndrome yavakadzidza.
Kunongoda 150 mitsara ye Costello syndrome yakabudiswa mumabhuku ezvokurapa pasi rose, saka hazvisi pachena kuti kazhinji sei chirwere chinowanzoitika kana kuti ndiani angangodaro achinetseka nacho.
Zviratidzo
Zviratidzo zvinowanzoitwa Costello syndrome ndezvi:
- kuoma kukuwana kuwedzera uye kukura mushure mokuberekwa, izvo zvinotungamirira kufupi kwenguva
- kunyanya kusvibiswa ganda pamutsipa, zvanza zvemaoko, zvigunwe, uye zvigaro zvetsoka (cutis laxa)
- kwete-kenza kukura (papillomata) kumativi emuromo nemhino
- chimiro chechimiro chemaziso chakadai semusoro mukuru, nzeve dzakadzika-terera dzine maziso makuru, mashizha, miromo yakakura, uye / kana mhino dzakakura
- kuora mwoyo kwepfungwa
- ganda rakaoma, rakaoma paganda nemaoko kana maoko nemakumbo (hyperkeratosis)
- zvinyorwa zvisinganzwisisiki zvinoenderana neminwe.
Vamwe vanhu vangave nemiganhu yekufamba pamakumbo kana kusimbisa kwetendon kumashure kwechidzitiro. Vanhu vane Costello syndrome vangave vane mwoyo unokanganisa kana chirwere chemwoyo (cardiomyopathy).
Kune huwandu hwakawanda hwekukura kwechirwere, vose vane kenza uye vasina-kenza, vanobatanidzwa nehutano pamwe chete.
Kuziva
Kuongororwa kwe Costello syndrome kunobva pakuonekwa kwomwana akaberekwa ane chirwere, pamwe nezvimwe zviratidzo zvinogona kuvapo. Vana vazhinji vane Costello syndrome vanonetseka kudya, uyewo kuwedzera kuwedzera uye kukura, saka izvi zvinogona kuratidza kuonekwa.
Mune ramangwana, mazita ekuongorora mazita ekuzivikanwa kwemajini anoshandiswa ne Costello syndrome angashandiswa kusimbisa kuongororwa.
Kurapa
Hapana hutano husinganzwisisiki hweCostello syndrome, kuitira kuti kurapwa kwechiremba kunotarisa pane zviratidzo uye zvinetso zviripo. Zvinokurudzirwa kuti vanhu vose vane Costello syndrome vakagadzirirwa kuongorora kwehupenyu kuti vaone kutadza kwemoyo uye / kana chirwere chemwoyo. Kurapa kwepanyama uye yebasa kunogona kubatsira munhu kuti asvike pakubudirira kwake. Nguva yakareba yekuongororwa kwechirwere kukura, mutsara kana matambudziko emapfupa, uye mwoyo kana kuwedzerwa kweropa kunokosha. Hupenyu hwomunhu ane Costello syndrome huchakanganiswa nekuvapo kwematambudziko emwoyo kana maronda ane kenza , saka kana uine utano, vanhu vane chirwere vanogona kuva noupenyu huripo.
> Sources:
> Costello Kids. Nezve Costello syndrome.
> Gripp, KW, uye al. (2005). HRAS kuchinja mutsika ku Costello syndrome: Genotype uye phenotype correlation. American Journal of Medical Genetics.
> Lin, AE, et al. (2002). Kuwedzera kujekesa kwepfungwa dzisina kunaka mu Costello syndrome. American Journal of Medical Genetics, 111 (2), pp. 115-129.
> Moroni, I., et al. (2000). Costello syndrome: Kenza predisposing syndrome? Clin Dysmorphol, 9 (4), peji 265-268.
> National Organisation for Rare Disorders. Costello Syndrome.
> Pascual-Castroviego, I., et al. (2005). Costello syndrome: Mharidzo yekodzero yekutevera kwemakore 35. Neurologia, 20 (3), mapeji 144-148.