Inositol iri kuratidza chivimbiso senzira yekutanga kurapwa kwevakadzi vose vane PCOS nekuda kwekukwanisa kwayo kugadzirisa zviratidzo zvekuberekwa nekubereka. Hezvino chaungaziva.
Inositols Are Secondary Messengers
Inositols dzakadai se myo uye d-chiro inositol (DCI), nhengo dzeB-vitamini uye chikamu chemukati membrane. Inositol inowanikwa muzvokudya zvakadai sezvibereko , nyemba, mbeu, uye marimu uye inogadzirwawo nemuviri.
Myo neDDCI vanoita sevatumwa vepachipiri vachitumira zviratidzo zvinosanganisira mutemo we insulin. Zvinotendwa kuti vakadzi vane PCOS vangave vane chiremera mumuviri wekodzero yekushandura MYO ku DCI, zvichiita kuti insulin isaramba uye kusagadzikana. Kuwedzera pamwe ne inositol kwakanyatsorambidzwa (hapana GI migumisiro yakafanana neye metformin) uye yakaratidzwa kuvandudza insulin mizinga uye kuderedza kushuva kwakasimba.
Mutsva weMyo uye D-Chiro Work Best
Kutsvakurudza kutsva mumigumisiro ye inositol kwakaratidza kuti huwandu hwemashupu mumuviri hune chiyero cheMyo kuDI ye 40: 1. Kutora kusanganiswa kwezviviri zvekuwedzera muzviyero izvi pane kungotora myo kana DCI chete, zvinokurudzirwa.
Kana ichienzaniswa neyo myo inositol, kusanganiswa kweMyo ku DCI kwakaratidza zvimwe zvakakosha pakuvandudza mararamiro emagetsi (kuderedza insulin, cholesterol, uye kuvhiringidza zviratidzo) kuvakadzi vane PCOS.
Pakaenzaniswa ne metformin , kuwirirana kwemyo naDDI muhuwandu hwe40: 1 kwakaratidza migumisiro yakanakisisa maererano nekurema kwekurema, ovulation, uye kutora mamiriyoni (46.7 vs11.2%).
Inositol Ratio Inoshusha Egg Quality uye Kubereka
Kusawirirana mumuviri wepamuviri hwemyo ku DCI chiyero kunogona kukanganisa mazai evha. Myo inositol yakaratidzwa kuvandudza mazai evha muvakadzi neCPOS asi DCI inotarisirwa pamatare (600-2400 mg zuva nezuva) yakawanikwa ichikanganisa hutano hweoocyte uye mhinduro ye ovari.
Zvinotonyanya kukosha, iyo yakasimudza mazamu eDII (uye iyo yakawanda yakaenzana nehuwandu hweMYO kusvika DCI), yakaipisisa maoocyte yepamusoro uye mhinduro ye ovarian yakava.
Inositol May Kuderedza Dambudziko reGestational Diabetes
Izvo zvave zvataurwa kuti vakadzi vane PCOS vangave vari pangozi yekuwedzera gestational chirwere cheshuga (GDM) mukuzvitakura. Zviongorori zvakaratidza kuti kuwedzera kwemyo inositol panguva yese yekuzvitakura kunobudirira pakuderedza dambudziko reGDM kuvakadzi avo vairema zvikuru uye vakadzi vane PCOS. Chidzidzo muGynecology Endocrinology yakaratidza kupararira kweGDM pakati pevakadzi vane pamuviri neCPOS avo vakatora myo-inositol boka raiva 17.4% kusvika 54% muboka rekutonga.
Sources
Hamid A et al. Zviratidzo-Zvakadzikwa nevakadzikadzi Health Journal. 2015; 5 (3): 93-98.
D'Anna R1, Di Benedetto V, Rizzo P, Raffone E, Interdonato ML, Corrado F, Di Benedetto A. Myo-inositol inogona kudzivirira gestational chirwere cheshuga muvakadzi vechiPOS. Gynecol Endocrinol. 2012 Jun; 28 (6): 440-2.
Costantino D, Minozzi G, Minozzi E, Guaraldi C. Metabolic uye mahomoni zvinokonzera myo-inositol kuvakadzi vane polycystic ovary syndrome: a doubleblind trial. Europ review med pharmacol sci. 2009; 13 (2): 105-110.
Unfer V, Carlomagno G, Rizzo P, Raffone E, Roseff S. Myo-inositol pane D-chiro-inositol anokwanisa kuvandudza maoocyte muhutano hwemainiteri inonzi intracytoplasmic. A tarisiro, anotungamirirwa, randomized trial. Europ review med pharmacol sci. 2011; 15 (4): 452-457.
Le Donne M, Alibrandi A, Giarrusso R, Lo Monaco I, Muraca U. [Zvokudya, metformin uye inositol muvakadzi vanopfuura kuwandisa uye vanopfurikidza ne polycystic ovary syndrome: zvinokonzerwa nokugadzirwa kwemuviri]. Minerva ginecologica. 2012; 64 (1): 23-29.
Venturella R, Mocciaro R, De Trana E, D'Alessandro P, Morelli M, Zullo F. [Kuongorora kwekushandurwa kwemakiriniki, endocrinal uye metabolical profile yevarwere vane PCOS syndrome inobatwa ne myo-inositol]. Minerva ginecologica. 2012; 64 (3): 239-243.
Genazzani AD, Prati A, Santagni S, et al. Kusiyanisa insulin inopindura myo-inositol inowanikwa mune obese polycystic ovary syndrome varwere. Gynecol Endocrinol. 2012; 28 (12): 969-973.
Gerli S, Papaleo E, Ferrari A, Di Renzo GC. Randomized, maviri blind blindbo-controlled trial: madzimai emyo-inositol pamusana weavarian uye zvinoshandiswa mumagetsi mumadzimai ane PCOS. Europ rev med washington sci. 2007; 11 (5): 347-354.
Raffone E, Rizzo P, Benedetto V. Insulin inokurudzira vashandi voga uye mukubatanirana neR-FSH nokuda kwekuvhara mavhiri muvakadzi vePCOS. Gynecol Endocrinol. 2010; 26 (4): 275-280.
Galazis N, Galazi M, Atiomo W. d-Chiro-inositol uye zvakakosha mu polycystic ovary syndrome: kurongeka kwakarongeka. Gynecol Endocrinol. 2011; 27 (4): 256-62
Papaleo, E., Unfer, V., Baillargeon, JP, et al. (2007). Myo-inositol mune varwere vane polycystic ovary syndrome: Nzira inozivikanwa yehuvhu induction. Gynecological Endrocrinology, 23 (12): 700-703.
D 'Anna R, Di Benedetto V, Rizzo P, et al. Myo-inositol inogona kudzivirira gestational chirwere cheshuga muvakadzi PCOS. Gynecol Endocrinol. 2012; 28 (6): 440-442.
Isabella R, Raffone E. Ane ovari inoda D-chiro-inositol here? J Ovarian Res. 2012 May 15; 5 (1): 14.
Dinicola S1, Chiu TT, Unfer V, Carlomagno G, Bizzarri M. Nheyo ye myo-inositol uye D-chiro-inositol yakabatanidzwa kurapa kwe polycystic ovary syndrome. J Clin Pharmacol. 2014 Nharo; 54 (10): 1079-92.
Nordio M, Proietti E. Kurapa pamwe chete ne-myo-inositol uye D-chiro-inositol kunoderedza ngozi yehutachiona hwehutachiona muhutachire hwePOSO hwehuwandu hunoenzaniswa ne myo-inositol supplementation chete. Eur Rev Med Pharmacol Sci. 2012 May; 16 (5): 575-81.
Colazingari S, Treglia M, Najjar R, Bevilacqua A. Mishonga inobatanidza myo-inositol pamwe naD-chiro-inositol, pane D-chiro-inositol, inokwanisa kuvandudza zviwanikwa zveVIV: zvinokonzerwa nechirongwa chinotaridzika chinotongwa. Arch Gynecol Chibvumirano. 2013 Dec; 288 (6): 1405-11.