Stelara Ndiyo Monoclonal Antibody Inoshandiswa Kuti Yakwanise Kuve yakakura Crohn's
Overview
Stelara (ustekinumab) inonzi biologic therapy inoshandisa interleukin (IL) -12 uye IL-23 cytokines. Zvimwe zvinonyanya kukosha ndeyevanhu vakazara monoclonal immunoglobulin antibody iyo inokonzera IL-12 uye IL-23 yakagoverwa P40 subunit. Stelara yakatanga kugamuchirwa muna 2008 kuzobata chironga cheporiasisis uye ikozvino yakagamuchirwa kutora chirwere cheCrohn chairo.
Chokwadi Chinokosha Chokuziva
- Stelara haisi mushonga weCrohn's disease
- Stelara inotanga kupiwa nekunyudzwa uye zvakare nemavikisi inogona kuitwa pamba
- Vanhu vane chirwere chemazuva ano havafaniri kugamuchira Stelara
- Pane ngozi yakawedzerwa yehutachiona uye chero zviratidzo zvehutachiona zvinofanira kukurukurwa nachiremba pakarepo
- Stelara haana kuverengwa zvakanyanya panguva yekudzivirira nekuyamwisa uye chiremba anofanira kubvunzurudzwa pakarepo pane zvakaitika
- Varwere vanofanira kuongororwa nehutachiona (TB) vasati vatanga Stelara
Administration
Stelara inopiwa mune imwe nzira yematatu. Mushonga wokutanga na Stelara unoitwa nekamukira. Mishonga yacho inopiwa intravenously mune imwe nzvimbo inopindira kana muhofisi yechiremba. Nhamba ye Stelara inoshandiswa inongororwa uye inorongwa zvichienderana nemutoro wevarwere. Shure kwaizvozvo, Stelara inopiwa nejasi remajekiseni (injini inopiwa pasi peganda) masvondo masere ose, anogona kuitwa kumba.
Varwere vanodzidziswa nekoti kana mumwe mudzidzisi wehutano nezvekupa majekiseni. Mushonga unouya mune imwe injector inokosha iyo murwere anozvipa ivo pachavo kana ane shamwari kana yemhuri inopa kwavari. Varwere vanogona kuvhara Stelara muhudyu, mimba, mabhuti, kana kuti kumusoro.
Zviratidzo
Stelara inogona kurairwa kuti iite chirwere chakakomba uye chakakomba cheCrohn muvanhu vanopfuura makore gumi nemana. Janssen Biotech, Inc, mugadziri weSlara, anoti mishonga iyi inobvumirwa kune varwere vane chirwere cheCrohn "vasina kukanganisa kurapwa nema immunomodulators kana corticosteroids asi haana kumbokwanisa kukanganisa kurapa ne tumor necrosis factor (TNF) blocker, kana kuti akakundikana kana kusakanganiswa kurapwa neye kana kuti vakawanda veTN blockers. " Izvi zvinoreva kuti ndeyekushandiswa mune varwere avo vaibatwa nemumwe rudzi rwemishonga uye havana kuvandudza. Izvi zvinogona kusanganisira immunomodulator zvinodhaka (izvo zvinoderedza maitiro ezvirwere zvemuviri), steroid sezvakaita prednisone , kana kuti TNF blocker (dzimwe nguva inonzi biologics).
Zvimwe zvipembenene zvisingagoni kupindira izvo Stelara zvinogamuchirwa muUnited States zvinosanganisira psoriasis uye psoriatic arthritis. Stelara haisi ikozvino yakagamuchirwa neRDA kuti irape chironda chekurwara. Stelara haibvumirwi kushandiswa muvana kana vechidiki vasati vava nemakore gumi nemasere.
Iyo Inoshanda Sei
Stelara yakashandiswa kurapa mamiriro ekudzivirira muviri, neCrohn's disease kuva chirwere chachangobva kuwanikwa icho chakawanikwa chakabudirira. Stelara inovhara interleuken (IL) -12 uye IL-23, iyo inowanikwa mumuviri nenzira yega asi inofungidzirwa kuti inobatsira kurwiswa muCrohn's disease.
Stelara haisi mushonga weCrohn's disease.
Ndiani Asingafaniri Kuitora
Udza chiremba wako kana uine kana wakambove nechimwe chezvinhu zvinotevera:
- A yekare inokonzera kugadziriswa kuna Stelara
- A latex kutengesa, nokuti siriniti inotanga kuzadzwa inogona kunge ine latex
- Iva nehutachiona hwekupedzisira nemushonga unorarama, kana nhengo yeimba yako ine chirwere chinorarama
- Wakagamuchira chirwere cheBibille Calmette-Guerin (BCG) nokuti haifaniri kupiwa mukati megore rokutora Stelara (zvimwe kana shure)
- Chero chero ruvara rweganda
- Iye zvino vari kutora shotti yemagetsi, kunyanya kukanganiswa kwemaitiro
- Wakambotapwa ne phototherapy (chirwere chechiedza)
- Kuberekwa kana kuyamwisa, kana kutora pamuviri kana kuronga kuyamwisa paanenge achitora Stelara
- Iva nenhoroondo yezvirwere kana hutachiona hwemazuva ano
Allergy Warning
Chikonzero chikonzero chiremba achadikanwa kuziva nezvezvenyeredzi shots uye kusuruvara kwakanyanya ndechokuti Stelara anogona kuchinja nzira iyo muviri unopindira kune iyo shots. Stelara inogona kuita zvirwere zvishoma zvishoma zvishoma kana kuwedzera mukana wekugadzirisa matambudziko mushure mokunge wawana pfuti. Zvakakosha kushanda pamwe chete ne-allergenist uye gastroenterologist kuderedza dambudziko rekugadzirisa zvirwere. Zviremera zvinokonzerwa nehutachiona kune Stelara hazviwanzoitiki.
Associated Infections
Stelara inogona kuwedzera mukana wekuve nehutachiona nokuti inogona kukanganisa maitiro echirwere . Varwere vanofanira kungwarira pamusoro pekucherechedza chero zviratidzo kana zviratidzo zvehutachiona uye vaudza kunechiremba pakarepo. Izvi zvinosanganisira:
- Marwadzo emudumbu
- Kukosora
- Kuchema ropa
- Diarrhea
- Kuneta
- Fever
- Uturu hunorwadza
- Pain or burning while urinating
- Kupfupika kwemhepo
- Ganda rinoputika
- Sweats
- Unexplained kuora kurasikirwa
Kudzivirirwa
Panguva yekudzivirira
Kubata pamuviri apo amai vaive vachigamuchira Stelara vasina kudzidza zvakanyanya. Pakave nemakemikari mashoma ekuzvitakura mumadzimai ane psoriasis avo vakanga vachitora Stelara. Izvo izvi zvose zvave zviitiko zvenyaya, zvinoreva kuti chiitiko chimwe chete chiri kuidzidzwa. Ikoko hakuna kumbove nedzidzo dzakawanda dzinotarisa kuti Stelara inobata sei vana vasati vaberekwa. Zvimwe zvakaguma nekuparara pamuviri, asi hapachina kuve nekutsvakurudza kwakakwana kuti uzive kuti kana Stelara aisazovhiringidza fetus.
Dhiyabhorosi yeDAA yekudzivirira kweStrara ndeyechimiro B. Izvi zvinoreva kuti zvinoita Stelara pamwana asati aberekwa hazvina kunyatsodzidza. Ikozvino inokurudzirwa kuti Stelara inofanira kushandiswa chete panguva yekuzvitakura kana zvakajeka inoda. Chiremba anorayira Stelara anofanira kutaurirana pakarepo kana kuberekwa kuchiitika.
Nemhaka yokuti pane zvishoma zvishoma nezvekudzivirira uye Stelara, ani naani anoita pamuviri anobvunzwa kuti atore chikamu mumabhuku ekudzivirira nekudana nekudana 1-877-311-8972. Izvi zvinogona kubatsira masayendisiti kudzidza zvakawanda nezvekuti Stelara inobata sei amai navana vacheche kuti vawedzere kutarisira vamwe varwere munguva yemberi.
Panguva yekuberekwa
Inofungidzirwa kuti Stelara anogona kudarika muchipfuva uye naizvozvo inotorwa nemucheche. Kuyamwisa mwana paanenge achiwana Stelara kunofanira kukurukurwa nevatungamiri veboka rehutano uye rinofanira kuitwa pamunhu mumwechete.
Shoko Rinobva
Stelara yakashandiswa kubvira muna 2008 kuzobata zvirwere zvemuviri. Ikozvino mamiriro ezvinhu ayo Stelara akatenderwa ndiyo Crohn's disease. Kunyange zvazvo Stelara isiri kurapa, yakaratidzwa kuva yakakosha pakurapa chirwere cheCrohn mune vamwe varwere.
> Sources:
> Engel T, Kopylov U. "Ustekinumab muCrohn's disease: uchapupu huripo uye nzvimbo munzvimbo yekurapa." Ther Adv Chronic Dis . 2016 Jul; 7: 208-214.
> Janssen Biotech, Inc. "Stelara Safety Information." 24 Sept 2016.
> Levy RA, de Jesús GR, de Jesús NR, Klumb EM. "Kuongorororwa kwakakosha kwezvino mazano ekurapa zvirwere zvehurmatic rheumatic panguva yekudzivirira uye lactation." Autoimmun Rev. 2016 Oct; 15: 955-963.
> Niederreiter L, Adolph TE, Kaser A. "Anti-IL-12/23 muCrohn's disease: bhenji uye mubhedha." Curr Drug Targets . 2013 Nov 14: 1379-1384.
> Rocha K, Piccinin MC, Kalache LF, Reichert-Faria A, Silva de Castro CC. "Kuberekwa panguva yeUstekinumab Kuchengetedzwa kweChevere Psoriasis." Dermatology . 2015; 231: 103-104.