Rheumatoid Arthritis Mwoyo muRituxan Kudzidza Kwakagadzirirwa Nyaya Dambudziko reMDC
Chirwere chinouraya cha PML (progressive multifocal leukoencephalopathy) chakaonekwa mune rheumatoid arthritis (RA) murwere akabatanidzwa mukuchengetedzwa kwekuchengetedzwa kwekuchengetedzwa kwechirwere cheRituxan (rituximab). Somugumisiro, iyo FDA nemuiti wezvinodhaka yakabudisa nyevero uye ichavandudza Rituxan inorondedzera mashoko kuisa PML.
Chii Chinonzi PML?
PML inozivikanwawo se progressive multifocal leukoencephalopathy.
Maererano neNational Institute of Neurological Disorders uye Stroke, "Progressive multifocal leukoencephalopathy (PML) inokonzerwa nekugadziriswa kwepurogiramu inowanikwa mukati mehutachiona hwemagadzirirwo evanhu vanodzivirira zvirwere." Polyomavirus JC (inowanzonzi JC virus) inotakurwa ne huzhinji hwevanhu uye hahukuvadzi kunze kwevaya vane simba rekudzivirira kudzivirirwa. "
Inonyanya Kuzivikanwa NezveRA Murefu Akakurira PML?
Ra murwere RA akanga atanga kuve nehutachiona hweJC uye apo PML. Rufu kubva kuna PML yakaitika mwedzi 18 mushure mekunge murwere agamuchira chiitiko chekupedzisira cheRituxan mukudzidzira nekudzivirira kuchengeteka.
Ra murwere RA akavewo nekenza yerororyngeal (kanha yehuro ) uye akabatwa nekemotherapy uye mazai emwedzi 9 asati atanga PML. Murwere akanga ane nhoroondo yakajeka yezvokurapa iyo ingadai yakaita kuti kukurudzirwa kweMDC. Kunze kweR RA, murwere aiva neSjogren's syndrome uye asingaoneki anobatsira C4 mazinga.
Murwere akabatwa ne methotrexate, steroids, uye neTN blocker asati agariswa neRituxan. Methotrexate uye steroid zvakashandiswawo panguva uye mushure mokurapa.
Chii chinonzi FDA Chichiita Mukupindurwa kuMusiki wePML?
I-FDA iri kudzoka zvakare kurondedzera mirayiridzo uye kuzivisa vashandi vezvehutano mune tsamba uye kuvanhu panzvimbo yepawebsite yayo pamusoro penhau inouraya yePLL.
Chii Chinofanira R RA Varwere Vanobatwa NeRituxan Do?
Sezvo nguva dzose, kurukurai zvamunofunga nechiremba wenyu. Nyanzvi dziri kurayira kuti kana murwere achibatwa neRituxan inokura zviratidzo zvehutano -kukurukurirana neyeurologist, uropi MRI, uye kuvharwa kwechirwere kunofanira kuonekwa. Varwere vanovaka PML havafaniri kurega Rituxan, zvichida vanorega kana kuderedza zvimwe zvirwere zvekudzivirira muviri, pavanenge vachifunga nezvehutachiona hwehutachiona. Asi, pane chaizvoizvo hapana mushonga unogona kugadzirisa PML kana ichikura.
Sources:
FDA: Nyaya Inouraya yeProgressive Multifocal Leukoencephalopathy muMurwere Kuwana Rituximab. Doctor's Guide News . September 11, 2008.
FDA Medwatch. Nyaya Inokosha Inodzivirirwa Nezvekugadzirira Progressive Multifocal Leukoencephalopathy Nokushandiswa kweRituxan. September 11, 2008.