OTC nhengo dzemvura dzakabuda mumvura dzine phenylephrine basa rakaipa.
Muna 2006, Mutungamiri Bush akasayina Mutemo weMethamphetamine Epidemic Act, kuchinjwa kwePatrioti Act, mutemo. Hondo yeMethamphetamine Epidemic Act yakagadzirirwa kuita kuti zvive nyore kuti vanhu vawane Sudafed nemamwe mabhuku ekudzivirira ane pseudoephedrine nekuendesa zvinhu izvi mushure mokutengesa kwemishonga, zvichida vachatenga kuti vape mufananidzo weZIDZ, uye vachidzivirira kutengesa kusvika ku7,5 gram per customer per month.
Uyezve, vazhinji vehurumende vakaisa mimwe mitemo yavo pseudophedrine yekutengesa. Iko kushandurwa kwakagadzirwa kuti kuregere kushandiswa kwemishonga iyi mukugadzirwa kwemugwagwa we methamphetamine mumugwagwa.
Mukuda kwekuchinja uku, vazhinji vanogadzira zvinodhaka vakashandura pseudophedrine nokuda kwe phenylephrine mune dzakawanda zvepamusoro pezvinyorwa zvinoputika pasi. Asi heino chinhu chine phenylephrine: Hazvibatsiri izvozvi. Kana iwe wakambotenga zvinhu kuti usiye mhino yako, zvimwe wakamboona zvishomanana kana kuti hapana zororo. Kunyanya kunyanya, kana zvichibvira uye zvachose zvichidikanwa kwekusunungurwa kwenguva pfupi, tenga yakazara-yekare Sudafed (iyo ine pseudoephedrin) pane Sudafed PE (ine phenylephrine). Uyezve, kana iwe uchida kusakanganiswa, iwe unofanirwa kuita nguva yekusangana kuti uone chiremba wako mukuru wekuchengeta.
Chii Chinonzi Pseudoephedrine uye Phenylephrine?
Zvose zviviri pseudoephedrin uye phenylephrine zvirwere zvinoratidzira zvinoshandisa tsitsi ("kurwisana kana kutiza").
Panofungidzira, mishonga iyi inofanira kukuomesa iyo ndiyo chikonzero iyo inowanikwa mukukanganiswa kwakasiyana-siyana uye kugadzirirwa kunotonhora kazhinji pamwe nekukanganiswa suppressants uye antihistamines. Nenzira, vatsvakurudzi vanoratidza kuti se phenylephrine, antihistamines haigoni kupindirana uye zviratidzo zvinotonhora.
Kunyanya, pseudoephedrine ine zvose zvakananga uye zvisingazivikanwi alpha- uye beta-adrenergic basa asi muchipatara zvinowedzera beta-adrenergic kukurudzira.
Kunyange zvakadaro, phenylephrine inorondedzera alpha-adrenergic agonist.
Kusiyana kukuru pakati pemishonga miviri kune chokuita nehuwandu hwakawandisa hwekutanga-kudarika metabolism. Kunyange zvazvo 90 muzana yepseudoephedrine inoitisa mumvura mukati mekushandiswa kwe systemic, 38 chete yezana ye phenylephrin inoita kuti ive muropa redu. Mune mamwe mazwi, iwe unopedzisira uchitarisa zvimwe phenylephrine kupfuura muviri wako unotora.
Tsvakurudzo yePhenylephrine
Kuti ive yakarurama, tsvakurudzo pamusoro pekushanda kwe phenylephrine pakusunungura musana kusanganiswa kunosanganiswa, uye munzvimbo yose. Semuenzaniso, meta-kuenzanisa kuenzaniswa kwe 10 mg phenylephrine nekutungamirirwa kwepa placebo kune vatsvakurudzi vekutsvakurudza vakaratidza kuti phenylephrin inogona kuderedza nasal airway resistance, biomarker yekuputika, nemapfumbamwe makumi maviri. Zvisinei, chidzidzo ichi chaibhadharwa nehurongwa hwemishonga yemishonga.
Zvakakwana randomized-control miedzo uye kumwe kuenzanisa kuenzanisa phenylephrine ne placebo zvakaitwa izvo zvinoratidza kuti hapana kusiyana pakati pezvinhu zviviri izvo zvichida phenylephrine haaiti zvishoma asi kununura chikwama chemadhora emari.
Nenzira, vamwe vatsvakurudzi vanotaura kuti nekuda kwekutanga-kudarika-metabolism kuwedzerwa kwenzako ye phenylephrine kunogona kubudirira kugadzirisa kupisa kwemvura.
(Ndapota kurukurai mishonga yose uye madheji nechiremba wenyu.) Asi ndiani anoziva? Izvo zvatinoziva ndezvokuti mumatokisi anonyadzisa aya madhiragi anonzi sympathomimetic ane zvinetso zvinosanganisira kushaya njere kuwedzera kweropa (hypertension), kusagadzikana kwemahymorrhage, kana kunyange kushungurudzika kwemoyo kunokonzera kuwirirana kana kunyange katatu kune imwe miitiro inotyisa.
Shoko Rinobva
Ndapota yeuka kuti kunyange iwe usingatsvaki mishonga yekushandisa zvinodhaka kupfuura-the-counter, ivo vachiri mishonga ine zvinogona kuipa. Iwe unofanira kugara uchibvunza chiremba wako mazano asati atora chero mishonga. Uyezve, kana uri kutora-zvinodhaka zvinodhaka kune chirwere, iwe unofanirwa kuva nechirwere ichi chinoongororwa nachiremba wako.
Kana iwe kana munhu waunoda ane dambudziko rinoshungurudza remasanganisvo emvura, zviite iwe unofadza uye usanyanya kubvisa mishonga ye-oral-oral (OTC) ine phenylephrine. Kana iwe uchifanira, uye nekushandiswa kwenguva pfupi usati waona chiremba wako mukuru wekuchengeta, funga nezvegadziriro ine pseudoephedrine (iyo inogona kushanda zvishoma pane phenylephrine) kana kuti decongestant yemvura mu spray form (topical decongestant).
Ndapota ramba uchiyeuka kuti kunyange zvazvo uchibudirira munguva shoma, kushandiswa kwenguva refu kwezvinyorwa zvepamusoro zvepamusoro zvinogona kukonzera kuputika kwemazino emvura, uhu hunotyisa hunopedzisira huchiwedzera kukura kweputi. Uyezve, kana kuungana kwako kana zvimwe zviratidzo zvinotonhora zvinopfuurira kwemazuva mashomanana, iwe unofanirwa kuita sarudzo yekuona chiremba mukuru wekuchengeta, mukoti mushandi kana mubatsiri wechiremba anogona kuona kana chirwere chako chiri chakanyanya kukura kuputika kwetachiona.
> Sources
> Benowitz NL. Chitsauko 132. Pseudoephedrine, Phenylephrine, uye Zvimwe Zvidhori. Mu: Olson KR. eds. Kutyisa uye Kuwedzerwa Kwemishonga, 6e . New York, NY: McGraw-Hill; 2012.
> Nyaya yakanzi "Efficacy uye kuchengetedzwa kweMuromo Phenylephrine: Ongororo Dzokuongorora uye Meta-Kuongorora" naRC Hatton nevanyori vanyori uye yakabudiswa muThe Annals of Pharmacotherapy muna 2007.
> Nyaya yakanzi "Oral phenylephrine: Kuchinja kusina basa kwe pseudoephedrin?" naL Hendeles naRC Hatton uye yakabudiswa mu Journal of Allergy and Clinical Immunology muna 2006.
> Nyaya yakanzi "Meta-Kuongorora kweEfficacy yeDose Ropa rePhenylephrine 10 mg Kuenzaniswa nePaintbo muVakuru neAlexal Nechirwere Chisungo Pamusana peCold Common" naC Kollar uye vanyori vanyori vakaparidzirwa muChitical Therapeutics muna 2007.
> Westfall TC, Westfall DP. Chitsauko 12. Adrenergic Agonist uye Antagonists. Muna: Brunton LL, Chabner BA, Knollmann BC. eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e . New York, NY: McGraw-Hill; 2011.