Inenge 1 muzana yezvakaipa zvose zvinosanganisira chirwere chetachiona, uye kanzera yehutano kanowanikwa katatu mune zvevakadzi. Munyika dzekuMadokero dzine mazinga akakwana eododhi mune zvekudya, huwandu hunonyanya kuzivikanwa hweaikenza ndeyekusiyana kwekenza yekenza inonzi papillary thyroid carcinoma . Nenzira inonakidza, kune vanhu vakuru vane mapirary thyroid carcinoma, masitasita ari kure haana kufanana.
Kunyange zvakadaro, metastases iri kure-iyo inotasva nzira yakashambadzira (kupararira kwemafupa) uye kuvhima mumasitomu anenge akaita mapapu nefupa-yakajairika kune rimwe rudzi rwekenza yakasiyana-siyana inonzi follicular thyroid carcinoma . Zvinotyisa, zviratidzo zvakadaro zvinogona kuva chiratidzo chinoratidza! Zvinosuruvarisa, vamwe vevanhu ava vane follicular thyroid carcinoma vakakundikana kupindura radiotherapy (radioiodine) mushure mekubviswa kwetachiona. Nokuda kwevanhu vane mwoyo murefu vakadaro nevanoramba, vanosiyanisa kanhi yekenza, mishonga lenvatinib (Lenvima) inogona kubatsira. Yezvinyorwa, lenvatinib inouya mu capsule form.
Zvimwe Pamusoro Pezvakasiyana-siyana zveKeroid Kanzer
Zvose mapairi uye follicular thyroid carcinoma inobva ku follicular epithelial cells murotori. Ivo vanoongororwa nezvivakwa uye nenyuchi. Mazana makumi mapfumbamwe nemashanu kubva muzana emakemikari ehutachiona anowanzoitika uye hapana nhaka yemhuri inowanikwa.
Miviri yekunze ndeyeyo chete inopupurirwa njodzi yekenza yekenza uye yakasiyana nekenza yekenza-kunyanya papillary yekenza yekenza-zvisinei, iodine yakawandisa kana kukwana inogonawo kuita basa.
Nekenza yekemapa, chirwere chetachiona kana kuti "maziso" ndiyo chiratidzo chinowanzosangana nacho . Nemhaka yekuti maruva akadaro anowanzo "kutonhora" pane utachiona hutachiona, hutano hwakanaka hwesingano (rudzi rwechipsy) inzira yakanaka yekuongorora zvirwere izvi.
Kusiyana nekenza yekenza inotanga kurapwa nekuvhiyiwa, iyo yakawanda-yakasimba kana yakachengetedza-inokakavadzana uye inobva pakubatanidzwa kwehutachiona uye lymph nodes. Mune zviitiko zvehupiritsi yehutachiona hwehutachiona iyo inowanikwa yakawanda (kure nemasitema), utachiona hwose hunofanira kubviswa kuitira kuti radioiodine itore.
Nenzira, mhando yekenza yeproid inowanzoonekwa nevanhu vakawanda mumakore avo makumi mashanu nemakumi matanhatu, uye kana ikasangana nemasikirwo, makore gumi ekupona ari 10 muzana. (Kazhinji, muna 2014, vanhu vanosvika 1 890 muUnited States vakafa nekenza yekameti yose.) Uyezve, chemotherapy haifaniri kutaridzika kubudirira mune avo vane kusiyana kwetachiona carcinoma.
Zvimwe Pamusoro paLenvatinib
Pasina kunyanya kutaura, lenvatinib inonzi tyitarine kinase inhibitor yakawanda inotarisirwa kuti inhibits mapoka emakondomu akabatanidzwa mumaronda ekukura nekugadzirisa. Mune mamwe mazwi, lenvatinib inhibits kukura kwemakumbo masero ari kure nehutachiona ayo akanganisa kurapa neodacid iodine.
MunaFebruary 2015 mushure mokudzokorora zvabuda kubva muchikamu chechitatu chechipatara, FDA yakagamuchirwa lenvatinib. Vatsvakurudzi vakatsvaga 392 vanhu vakasiyana-siyana nekenza yekenza iyo yakanga isinganzwisisi redioiodine. Kunyanya zvakanyanya, lenvatinib yaibatanidzwa kune vatori vechikamu 261 apo vatori vechi1 131 vakagamuchira placebo.
Zvakakosha, chidzidzo ichi chakanga chakagadzirwa nekaseka iyo yakaita kuti vanhu vane hutano hwekuwedzera kubva ku placebo kuenda ku lenvatinib. Nemhaka yekodha yakadaro, vatsvakurudzi vakanga vasingakwanisi kuderedza kana lenvatinib ichiwedzera kukurarama kwenguva yakawanda.
Asi vatsvakurudzi vakanga vachikwanisa kuratidza kuti kupfuurira kwepakati-kusununguka kusina mwedzi kwakange kuri 18.3 mwedzi muboka rekuedza kana avo vanogamuchira lenvatinib kana 3.6 mwedzi kune avo vari muboka rekutonga avo vakagamuchira placebo.
Forty muzana yevatori vechikamu vanotora lenvatinib vakave nemigumisiro yakaipisisa iyo, mumatambudziko mazhinji, aitungamirirwa nekugadzirisa kuyerwa kwemishonga.
Kunyange zvakadaro, 14,2 kubva muzana yevatori vechikamu vachitora lenvatinib vakadonha kubva muchidzidzo, uye 6 kubva ku 20 kufa kwakaitika mukati memwedzi gumi nemana yekudzidza vakaonekwa sevakakonzerwa nemishonga.
Kunyanya, apa pane zvimwe zvinokanganisa lenvatinib:
- hypertension (67,8 muzana yevatori vechikamu)
- chirwere (59.4 muzana yevatori vechikamu)
- kuneta (59 muzana yevatori vechikamu)
- kuderedza kuda kudya (50.2 muzana yevatori vechikamu)
- kuderedza kuyerwa (46.4 muzana yevatori vechikamu)
- kushungurudzika (41.0 muzana yevatori vechikamu)
Kakawanda, migumisiro inobva kuedza ichi inoratidza kuti kune avo vane mararamiro echitachiona akasiyana-siyana anokonzera kusagadzikana ne radiotherapy, lenvatinib inogona kumisa kenza yakaipisisa kufambira mberi. Kana iwe kana munhu waunoda ari kutambura nezvirwere zvakadaro zvinouraya, zvitsva zvekudzidza uku zvinokurudzira. Zvisinei, kutsvakurudza kwakawanda kunofanira kuitika kuitira kuti uone kuti ndiani anoda mushonga wacho, zvii zvinotapisa zvinoshanda, uye kana kumira kubudirira kunoendesa kune huri nani hwehupenyu. Mushure mezvose, kunyange marapirwo anobudirira zvikuru anoreva zvishoma kana hupenyu hwako hunotyisa.
Sources:
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Chinyorwa chinonzi "Lenvatinib inowedzera kupona mukurwisa kenza yekenza" naSy Mayer kubva kuThe Lancet yakabudiswa muna 2015.
Chinyorwa chinonzi "Chiremba Chekuvhiya Kwemavara Akasiyana-siyana eTroroid Cancer: Guideline Guidelines" neG GA Rahman kubva kuOman Medical Journal yakabudiswa muna 2011.
Chinyorwa chinonzi "Lenvatinib uye Placebo muRadioiodine Refractory Thyroid Cancer" naM M Shlumberger uye vanyori vanyori kubva kuNJM yakabudiswa muna 2015.