Glioblastoma, inozivikanwawo seglioblastoma multiforme, GBM, kana kuti grade 4 astrocytoma , ndeimwe yevanhu vanowanzosiyana uye vane utsinye hwemakumbo europi, zvichiita zvinenge makumi mashanu kubva muzana zvegliomas ose.
Ndezvipi zviratidzo zveGGM?
Kunyange zvazvo GBM inowanzoitika mushure memakore makumi mashanu, inogona kuitika kuvanhu vaduku pamwe chete, zvichikonzera misoro, kukanganisa, uye zvinetso zvakanyanya zvepfungwa dzepfungwa zvakadai sekutaura kwekutaura kana kuchinja kwekuziva.
Zvimwe zviratidzo zveglioblastoma zvinosanganisira utera, kusina simba, chiratidzo chinoshanduka, uye hupenyu hunochinja. Zviratidzo izvi zvinopesana zvichienderana nekukura kwechiremera uye nzvimbo.
Kufambira mberi kweBGM Kunokurumidza Sei?
Makero anokonzerwa neKGM akapararira nokukurumidza. Chirwere ichi chinopararira zvakananga kuburikidza neuropi pasina ruzivo rwakajeka, zvichiita kuti zvive zvakaoma kana zvisingaiti zvachose kubvisa zvachose chirwere. Ivhareji yenguva kubva pazviratidzo zvokutanga kusvika pakufa inenge gore rimwe chete, kunyange izvi zvinowanzosiyana pakati pevanhu. Inenge 25 muzana yevanhu vanogona kupona kwemakore maviri kana kupfuura nekurapa.
Chii chinokonzera GBM?
Glioblastoma multiforme, kufanana nemamota ose, inokonzera kusakanganiswa kwema cell cell. Munyaya iyi, maglial cells anowanzokomba nekudzivirira masero emagetsi europi achiwedzera pasina kudzivisa. Izvi zvinokonzerwa nekuchinja kwekuti majini mumasero anotsanangurwa sei-somuenzaniso, masero anogona kunge akawedzera mazwi ekugadzira mune dzimwe nzvimbo dzakadai se epidermal growth factor receptor (EGFR) kana kurasikirwa kwechirwere chinodzvinyirira gemu se PTEN.
Zvimwe zviitiko zvinosanganisira MDM2 uye RB gene.
Vanachiremba Vanoziva Sei GBM?
Kana murwere ane zviratidzo zvinenge zvichinyunyuta, vanachiremba vanowanzotanga chirwere cheurouroimaging seMRI scan yeuropi. Pamusoro peMRI, GBM ine maitiro asingaoneki, kazhinji ine nzvimbo yepamusoro yezvinyorwa zvakafa kana kuora ropa, uye nzvimbo yakajeka yakapoteredza tumarara inowedzera ne gadolinium kusiyana.
Izvo zvisina kufanira zvinogona kuomerera pane dzimwe hutano hwehuropi uye kunokanganisa chimiro chakanaka cheropi.
Kunyange zvazvo zvimwe zvinhu zvingaita izvi zvichionekwa paMRI, chiremba ane hanya angazoedza kuronga kuti neurosurgeon inotora chikamu chezvipembenene izvi zvisina kujairika kubva muuropi. Iyo miviri inogona kuongororwa pasi pe microscope, iyo icharatidza nhamba yakakura yemasero akaparadzanisa mu "chimiro che" pseudopalisading ", zvinoreva kuti masero anoita seanosimudzwa. Izvi zvingangodaro zvakabatana nesero kufa, sezvo kugadzirwa kwavo kwakatarisana nenzvimbo dzemafu akafa anoonekwa muGMM pasi pe microscope.
Gwaro Rinogona Kuitwa Sei?
GBM ine utsinye uye inorwisa mishonga yakawanda. Kazhinji chinangwa chezvirapa izvi ndechekuderedza zviratidzo uye kuwedzera upenyu panzvimbo yekurapa zvachose chirwere.
Kurapa kwe glioblastoma multiforme kunowanzobatanidza zvitatu:
- Kuvhiya -Doctors vanobvisa zvipembenene zvakawanda sezvavanokwanisa kunze kwekukuvadza nzvimbo dzakanaka dzeuropi.
- Chemotherapy -Medicines inopiwa kuedza kutarisa tumarara masero. Temozolamide kana kusanganiswa kwe procarbazine, lomustine, uye vincristine mamwe emishonga yakajairika.
- Radiation therapy -Kuburitswa kunowanikwa kuuropi kunogona kuuraya zvimwe zvemasero emukenza. Izvi zvinowanzobatanidza kuisa mazairo mumuranda kune chimwe chikamu cheuropi, panzvimbo pekuchenesa uropi hwose sehuwandu hwemamwe matumbo ane simba.
Pashure pemishonga iyi yose, vanhu vane GBM vakateverwa kuti vaone kana chirwere ichi chinodzoka. Nguva zhinji, nguva yakaipa, iyo GBM inodzoka. Panguva iyoyo, kumwe kurapwa kunogona kukurudzirwa pane imwe nyaya-ne-case based. Nemhaka yekuti GBM yakanyanyisa uye nekuti kurapa kunowanikwa kunogona kuva nemigumisiro yakakomba, kutungamirirwa kwekenza iyi kune munhu oga uye kunosanganisira kushanda pamwe chete neyanzvi yehutano uye neurosurgeon.
Sources:
A Omuro, LM DeAngelis: Glioblastoma nedzimwe zvirwere zvinouraya: kuongorora kliniki. JAMA: iyo magazini yeAmerican Medical Association . (2013) 310: 1842-1850.
H Ropper, MA Samuels. Adams naVictor's Principles of Neurology, 9th ed: The McGraw-Hill Companies, Inc., 2009.