Ranexa (ranolazine) ine mishonga mitsva, ine nzira yakasiyana-siyana yekuita, yakashandiswa pakurapa angina . Ranexa yakaratidzwa kuti inonyatsovandudza nguva yakawanda nevarwere vane angina vakachengetedza vanogona kushandisa muviri vasati vatanga zviratidzo uye vakabvumidzwa neDFA muna 2008 sevashandi vekutanga kune angina.
Pakutanga zvakatendwa kuti Ranexa akaita kuti mwoyo mushure ushanduke kubva kushandisa mafuta acid to glucose yekugadzira magetsi, izvo zvingaderedza kuwanda kwomweya mutsara wemwoyo unoda kushanda.
Munguva pfupi yapfuura, zvakadaro, humwe uchapupu hwakaonekwa hwakaratidza kuti mhedzisiro huru yeRanexa ndeyekudzivisa izvo zvinonzi "nguva yekupedzisira sodium" mumasero emwoyo, ayo ari kutambura neIschemia , kana kushaya oxygen inobatanidza ne atherosclerosis , mumakoroni eronary . Kudzivirira iyi saruminiri inovandudza metabolism mu ischemic moyo masero, kuderedza kukuvadza kumutsipa wemwoyo, uye kuderedza zviratidzo zvema angina.
Chii Chinonzi Angina?
Angina inorwadza kana kusagadzikana mubhokisi rinobva pamwoyo wemisvo iyo inorambidzwa neropa rega-oxygen. Vamwe vanotsanangura manzwiro sekumanikidzirwa kana kufambisa, uye kusuruvara kunogona kunzwika mumapfudzi, maoko, mutsi, mutsva kana kumashure mune chifukidzo. Kutambudzika kweAngina kunogona kutonzwa sekundirika.
Angina chiratidzo kune pane chirwere chiri mukati maro. Kazhinji, inoratidza chirwere chemwoyo (CHD) semugumisiro wekuderedza imwechete kana kuti mamwe emakironi anonzi coronary, anozivikanwa se ischemia.
Ranexa inoshandiswa kurapa chirwere chisingagumi, asi kune mamwe akawanda emhando dzeanginawo, kusanganisira microvascular angina, Prinzmetal's angina, rakasimba angina, angina isina kusimba uye akasiyana angina.
Ranexa Side Effects
Nyaya dzakawanda dzinorondedzerwa nemigumisiro yeRanexa inonzi misoro, kuvimbiswa, uye kushungurudzika.
Mimwe migumisiro yechirwere yakaoma ingasanganisira:
- chizivo kana kuti kuchinjwa
- headache
- dry mouth
- kushaya simba
- kuridza munzeve
Mukuwedzera, kana uchitora Ranexa, zvakakosha kubhadhara kune chimwe chezviitiko zvinotevera zvakakomba uye tsvaga kutungamirirwa nokukurumidza kubva kuchiremba kana zvikaitika:
- kunzwa sokunge iwe unogona kupfuura
- kuzvirumbidza mumaoko, makumbo, kana tsoka
- kunonoka, kutsanya, kana kuora mwoyo
- kudengenyeka
- ropa mumuyo
- kunyura kashoma kana kwete zvachose
- kukurumidza kufema
- misoro, kupwanya, kurira, kupera, kurwadziwa, kana kushaya simba musimba
Pakutanga, chinetso chikuru pamusoro peRanexa ndechekuti inogona kupedzera "nguva yeKT" pane ECG (chiyero chekugadzira magetsi mukati memwoyo). Mamwe madhiragi anokonzera izvi anogona kuwedzera mungozi yekuva nehutano hwemwoyo . Kunyange zvakadaro, zvidzidzo zvakanyatsoratidza kuti njodzi yacho haigoni kana kuti haina Ranexa. Zvechokwadi, Ranexa ikozvino yakaratidzwa kuti chaizvoizvo kuderedze njodzi yekukudziridza ventricular arrhythmias uye atrial fibrillation .
Mukuwedzera, vanhu vane cirrhosis (kupora) kwechiropa havafaniri kutora Ranexa, uyewo havafaniri kutora St. John's wort nemimwe mishonga ye:
- fungus zvirwere
- zvirwere
- kuora mwoyo
- HIV
- tuberculosis (TB)
- seizures
Sources:
Chaitman, BR. Ranolazine kuitira kurapwa kwechirwere angina uye inogona kushandiswa mune imwe mamiriro emwoyo. Circulation 2006; 113: 2462.
Morrow DA, Scirica BM, Karwatowska-Prokopczuk E, et al. Migumisiro ye ranolazine pamusoro pezviitiko zvekare zvepfungwa kune varwere vasina-ST-elevation acute coronary syndromes. The Merlin-TIMI 36 randomized trial. JAMA 2007; 297: 1775-1783.
Belardinelli L, Shryock JC, Fraser H. Maitiro e ranolazine chiito kuti kuderedze ischemia-inonzi diastolic dysfunction. Eur Heart J Suppl (February 2006) 8 (suppl A): A10-A13. doi: 10.1093 / eurheartj / sui091.