Neulasta (pegfilgrastim) imishonga dzimwe nguva inoshandiswa panguva yekenza yemazamu chemotheropiro kuwedzera dhena reyero yakawanda yeropa kuitira kuti kuderedza dambudziko rezvirwere. Chii chaunoda kuziva nezvechirwere ichi, kusanganisira zvinogona kuitika?
Neulasta (Pegfilgrastim)
Neulasta (pegfilgrastim) chirwere chinopiwa kune vanhu vane kana kuti vanotarisirwa kukura chemotherapy-induced neutropenia (aine neutrophil count, rudzi rumwe rwechichena chemuviri weropa) panguva yekenza yekenza yemakemikari.
Neulasta inoshandiswa purogiramu ye granulocyte colony-inokurudzira chinokonzera (G-CSF), chigadzirwa chinokurudzira kugadzirwa kwemasero matsvuku eropa mumapfupa emapfupa. Iyo yakajeka mvura iyo inowanzopiwa sepfuti umo iyo tsono inowanikwa pasi peganda.
Neulasta inogara kwenguva refu yakashandisa mishonga iyo inowanzodiwa kamwe chete inotevera chemotherapy infusion, kusiyana neNeupogen (filgrastim), iyo inopa zuva rega rega kwemazuva anoverengeka nekujowa.
Shandisa Kenza Kanzvadzi
Chemotherapy nokuda kwekenza yemazamu inobata zvose zvinoparadzanisa masero mumumuviri wako, kusanganisira bone marrow cell, zvinounza masero eropa dema, masero matsvuku eropa, uye maplatelet. Izvozvo zvinoshandiswa mumapfupa ekurapa panguva yemakemikari zvinogona kukonzera anemia (aine tsvuku tsvuku yemasero kuverengera), neutropenia (aine neutrophil count) uye thrombocytopenia (aine pasi platelet count.)
Nhamba yakaderera neutrophil (dzimwe nguva inongoti yakaderera ropa rekuyera masero) inogona kuva yakakomba pakuti inokwanisa kutora vanhu kugamuchira chemotherapy kune zvirwere.
Chinangwa chekushandisa Neulasta ndechekubatsira kudzivirira zvirwere izvi.
Nzira Neulasta Inoshanda Sei
Kazhinji, muviri wako unobereka puroteni inokurudzira kugadzirwa kweeutrophils. Pakati pemakemikari, muviri wako pachawo unogadzirwa neutrophils, Neulasta inoshandiswa kukurudzira kugadzirwa kweeutrophils, uye kukura nekuita kuti neutrophils isati yavapo.
Sei Neulasta inopa Given
Iwe uchawana mujenya weNeulasta maawa makumi maviri nemaviri mushure mekuita chemotherapy yako. Izvo zvingasazopiwa nokukurumidza nokuti zvingasava zvishoma. Kusiyana neNeupogen, iyo inofanira kupiwa zvakare kusvikira yako yeutrophil ichikwira, Neulasta inopiwa kamwechete kamwechete kwe 2-kana 3-week chemotherapy cycle. Iwe unogona kuva nejoyi iyi mune ruoko rwako rwepamusoro, mudumbu, chidya, kana mabhuti.
Vamwe vepancologist vane varwere vanozvipa jekiseni ravo zuva rinotevera chemotherapy, uye rinowanzoerekana ra "mujoyi wemiviri" iripo zvakare. Mamwe oncologist vanokurudzira kuti une jekisi pakliniki yako kana newaunotarisira chiremba wepamusoro kana iwe uchinge wakagadziriswa kune zvinodhaka.
Alternatives to Neulasta
Sezvambotaurwa, imwe nzira yaNeulasta (pegfilgristim) ndiyo Neuopogen (filgristim). Dzimwe nguva an oncologist achabvunza kuti mishonga yaunoda. Kunyange zvazvo mishonga inoshanda nenzira imwe chete, kune zvimwe kusiyana pakati peNeulasta neNeupogen pamwe chete, kusanganisira nguva yakawanda yejojo, kubvumira, uye mari.
Mamwe Maitiro Akasiyana-siyana
Chimwe chezvinhu zvakakomba migumisiro inobva kuNeulasta inoratidzika, uye zvakare, ichi ndicho chikonzero kuti vamwe vevccologist vanoda iwe kuti kupfura kwaitwa kuchipatara.
Kana iwe ukazvipa iwe shotsti yako kumba, unofanira kunge uchiziva zviratidzo zvekuti zvinogona kuitika zvinokonzerwa nemagetsi kana anaphylaxis.
Fivhi inogona kuitika, uye zvakakosha kuti chiremba wako aone kana fevha yako yakakonzerwa nejecha rako, kana kuti pane utachiona hunoenderana nekuderedza ropa rako rekuyera ropa.
Inenge chikamu chetatu chevanhu vakapiwa majekiseni eNeulasta vanotaura mamwe maronda emapfupa. Ongororo yapfuura yakawana kuti Naprosyn / Aleve (naproxen) yakagadzirisa marwadzo ose emapfupa uye kuvhiringidza kurara (zvichida nemhaka yemarwadzo emapfupa). Munguva pfupi yapfuura yakawanikwa kuti antihistamine Claritin (loratidine) zvose zvakaderedza dambudziko remigumisiro yakaipa uye zvakaita kuti vashomanana vasiye mishonga kupfuura avo vaibatwa neAleve / Naprosyn (naproxen).
Kana iwe ukacherechedza kurwadziwa kwepfupa, taura nachiremba wako pamusoro pemishonga inokurudzira yaunoshandisa. Kunyura mubhati rinoshambadza kunogona kubatsirawo nemarwadzo emapfupa kubva kuNeulasta.
Dana Doctor wako kana Une Zviratidzo izvi
Zvisingabatsiri zvikamu zvinowanzoonekwa uye kusagadzikana kwakaipa kunogona kuitika, uye zvakakosha kudana wako oncologist kana iwe uine zviratidzo zvinokubatsira iwe. Izvi zvinonyanya kukosha kana iwe uchicherechedza:
- Kuneta kusinganzwisisiki uye utera
- Chipfuva chepfu
- Heart palpitations
Zviratidzo Zvokukurumidza Zanganisira
Iwe unofanirwa kudana chiremba wako pakarepo, asi tsvaga kurapwa nokukurumidza (kudana 911) kana ukacherechedza zviratidzo zvinoratidza kufanana neanaphylactic reaction (zvakanyanya zvinogadzirisa zvirwere) zvakadai se:
- Hives
- Kuoma kufema kufema
- Kutamba kwechiso chako, miromo, rurimi, kana huro
- Kurwisana kunopararira pamusoro pemuviri wako
- Urombo hwepamuviri, kunyanya kurwadziwa muruboshwe rwako kumusoro
- Dambudziko guru refudzi
Njodzi Inogona Kuitika yekushandisa Neulasta
Neulasta imishonga yakachengeteka inoshandiswa kune marudzi mazhinji eutrotenia, uye nguva yakawanda yenguva, migumisiro kana njodzi yemishonga inopfuura mungozi yepamusoro neutrophil count. Kukanganisa kwakaipa kunowanzojairika (asi dzimwe nguva kunoitika) kunosanganisira:
- Zviremera zvinokonzerwa neharagic.
- Munhu akaremara kupemha chirwere (ARDS) .
- Sickle cell crisis muvanhu vane sickle cell anemia.
- Splenic rupture .
- Zvinogona kuita kuti chirwere chiwedzere kukura (iyi inogona kunge yakakosha uye haina kuratidzirwa, sezvakaita Neulasta chikura)
Ndivanaani Vanofanira Kudzivisa Iyi Mishonga
Usatora ichi chirwere kana:
- Iwe uri nepamuviri kana kunwisa
- Iwe une allergiki kuNeulasta
- Iwe une allergiki kune zvigadzirwa zvakagadzirwa uchishandisa bhakitiriya E. coli
Zvinorayira Purogiramu
Pamberi pejekisi yako yokutanga yeNeulasta, chiremba wako acharonga CBC (nguva yakazara yeropa) kuti uone mazinga emaaplatelet ako uye matsvuku nemasero eropa, achicherechedza zvakakwana nhamba yakakwana yeeutrophils muropa rako. Sezvo kurapwa kuchifambira mberi, iwe uchange uine dzimwe ropa kuongororwa kuti uone kubudirira kweNeulasta.
Kana iwe uchiyamwisa kana uine pamuviri, kurukura izvi nechiremba wako usati watora Neulasta. Ikoko hakuna kuve nekuongororwa kwakakwana kunoitwa kuti uone kushanda kwechirwere ichi pamukaka wemuviri kana kuti fetus mwana.
Kuderedza Ngozi Yenyu Yezvirwere Panguva yeKemotherapy
Kunyangwe iwe uri kugamuchira majekiseni eNeulasta kusimudza ropa rako rekuyera masero, iwe unogona kunge uchiri pangozi yekugadzirisa utachiona munguva yechemotherapy. Dzimwe nguva masero machena eropa, kunyange kana pane zvakakwana, haabatsiri zvakare. Uye kunyange nekushandisa Neulasta, unogona kunge uine dzimwe nguva mushure mekuputika kwako apo danda rako rekuyera ropa rinowira pasi pemakero apo zvirwere zvinowanzoitika. Tora nguva yekudzidza pamusoro pezvaungaita iwe pachako kuti uderedze njodzi yako yehutachiwana panguva yechemotherapy . Hint: zvimwe zvezviyero izvi hazvisi kuzivikanwa uye zvingakushamisa iwe.
> Sources:
> Aapro, M., Boccia, R., Leonard, R. et al. Kutsanangurira Basa rePegfilgrasti (A Long-Actifing G-CSF) yekudzivirira Chemotherapy-Inobatsira Febrile Neutropenia: Consensus Guidance Recommendations. Kuchengetedza Kuchengetedza muCancer . 2017. 25 (11): 3295-3304.
> Botteri, E., Krendyukov, A., naG. Curigliano. Kuenzanisa Granulocyte Colony-Stimulating Factor Filgrastim naPegfilgrastim kune maBhiosimilars mumagariro eEfficacy uye Safey: A Meta-Kuongororwa kweRandomized Clinical Trials muArper Cancer Patients. European Journal of Cancer . 2018. 89: 49-55.
> Kirshner, J., McDonald, M., Kruter, F. et al. NOLAN: A Randomized, Phase 2 Kudzidza Kuenzanisa Kubudirira kweProphylactic Naproxen kana Loratidine vs No Prophylactic Treatment paAra Pain in Vatachiona Vokutanga-Stage Kanzvadzi yeChechi ichiwana Chemotherapy uye Pegfilgrastim. Kuchengetedza Kuchengetedza muCancer . 2018. 26 (4): 1323-1334.